Multiple bone tuberculosis in the young

Cremin, B. J.; Fisher, R M; Levinsohn, Morris W.

doi:10.1259/0007-1285-43-513-638

Cited by 22 publications

(3 citation statements)

References 6 publications

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“…In children, a very specific, but uncommon form of bone tuberculosis was described under various different names in medical writing from the preantibiotic era: Multiple cystic tuberculosis of bone, Osteitis cystica tuberculosis multiple, Cystic tuberculous osteitis, Multiple pseudo‐cystic tuberculosis , recalling the different clinical and especially radiological appearances of the lesions (Ellis, 1940; Martin & Fogel, 1941; Komins, 1952). Finally, the term multiple bone tuberculosis was generally accepted (Cremin et al ., 1970).…”

Section: Discussionmentioning

confidence: 99%

Multiple bone tuberculosis in a child from predynastic Upper Egypt (3200 BC)

Dabernat

Crubézy

2010

Intl J of Osteoarchaeology

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Tuberculosis, one of the most ancient human diseases, was present in ancient Egypt and has been observed since predynastic times. Excavations in the predynastic to early dynastic necropolis of Adaima, Upper Egypt (3500-2700 BC) led to the discovery of a number of remarkably well-preserved skeletons of children. The skeletal remains of a 4.5-5-year-old child dated from Nagada III A2 (3200-3100 BC) displayed various lesions on the post-cranial skeleton: spondylitis on the thoracic (T12) and lumbar (L1) vertebrae, partial lytic destruction of the right radio-ulnar joint, lytic lesions on the scapula and a clavicle, dactylitis on the short bones of hands and feet, enlargement (spina ventosa) and periosteal new bone formation on the long bones. Radiographs show well-defined radiolucent (cyst-like) lesions in the metaphysis and the diaphysis of long tubular bones (ulna, radius, femur, tibia, fibula). The lesions recorded during macroscopic and radiological analysis strongly suggest a case of multiple bone tuberculosis. The occurrence of this case of tuberculosis in a child provides a picture of a period where tuberculosis must have been endemic throughout the population living during the origins of urban settlement in Upper Egypt during the predynastic period.

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Section: Discussionmentioning

confidence: 99%

Multiple bone tuberculosis in a child from predynastic Upper Egypt (3200 BC)

Dabernat

Crubézy

2010

Intl J of Osteoarchaeology

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“…Taking into account the overall nature and pattern of the lesions, it is proposed that they are most compatible with a diagnosis of multifocal (or multiple) bone TB (Cremin et al, 1970). This is a condition described especially in children as multiple cystic or pseudocystic TB (e.g.…”

Section: Differential Diagnosismentioning

confidence: 99%

A 6500-year-old Middle Neolithic child from Pollera Cave (Liguria, Italy) with probable multifocal osteoarticular tuberculosis

Sparacello

Roberts

Kerudin

et al. 2017

International Journal of Paleopathology

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Citation for published item: p r elloD it le F nd o ertsD gh rlotte eF nd uerudinD emmielle nd w¤ ullerD omy @PHIUA 9e TSHHEye rEold widdle xeolithi hild from oller g ve @viguri D st lyA with pro le multifo l osteo rti ul r tu er ulosisF9D sntern tion l journ l of p leop thologyFD IU F ppF TUEURF Further information on publisher's website: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details.

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“…Tuberculosis and congenital syphilis cause bone lesions in infants and young children but are rarely reported in the same child. 1,2 Dactylitis is present but rare in both diseases. [2][3][4] Although the combination of dactylitis and multiple cystic lesions is typical of multiple bone TB, the clinical feature of condylomata lata and the severe periosteal reaction in the long bones lead to the suspicion of congenital syphilis.…”

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confidence: 99%

Radiological Case of the Month

Pr²

2000

Arch Pediatr Adolesc Med

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A 13-MONTH-OLD girl fell and had painful swelling of the right ankle on which she did not want to bear weight. Delivery was at term after an uncomplicated pregnancy. The mother's venereal disease research laboratory serology test for syphilis was negative early in pregnancy, and it was not repeated. Immunizations, including BCG vaccine, were up to date. Two adults in the household had pulmonary tuberculosis. The child was not

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Multiple bone tuberculosis in the young

Cited by 22 publications

References 6 publications

Multiple bone tuberculosis in a child from predynastic Upper Egypt (3200 BC)

Multiple bone tuberculosis in a child from predynastic Upper Egypt (3200 BC)

A 6500-year-old Middle Neolithic child from Pollera Cave (Liguria, Italy) with probable multifocal osteoarticular tuberculosis

Radiological Case of the Month

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