2012
DOI: 10.1136/bcr.11.2011.5198
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Multiple brain lesions in a young man with hypernatraemia

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Cited by 4 publications
(3 citation statements)
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“…It is known that sudden lowering of sodium (i.e., more than 10 mEq/day) may affect brain function and myelinolysis is expected, but such a high level of sodium once achieved is always detrimental to the brain tissue. [ 2 3 4 ] Even lowering sodium at a slow rate would not helpthe neurological status to improve. [ 5 ] As in our report, MRI brain revealed progressive lesions with cortical and subcortical demyelination even after the hypernatremic state was corrected.…”
Section: Discussionmentioning
confidence: 99%
“…It is known that sudden lowering of sodium (i.e., more than 10 mEq/day) may affect brain function and myelinolysis is expected, but such a high level of sodium once achieved is always detrimental to the brain tissue. [ 2 3 4 ] Even lowering sodium at a slow rate would not helpthe neurological status to improve. [ 5 ] As in our report, MRI brain revealed progressive lesions with cortical and subcortical demyelination even after the hypernatremic state was corrected.…”
Section: Discussionmentioning
confidence: 99%
“…El mecanismo de la MCP sería entonces una desmielinización osmótica (11). Se han comunicado casos de mielinolisis pontina con sodio normal, con ascenso lento de la natremia (12) o incluso en presencia de hipernatremia (4,7,(13)(14)(15)(16)(17)(18). La MCP puede darse en el contexto de enfermedades muy diferentes: enfermedades psiquiátricas como psicosis aguda o esquizofrenia (19,20), encefalopatía no alcohólica (21), diabetes (16), diálisis (14,22) o falla hepática aguda (23).…”
Section: Hiponatremia Y Elevación De La Osmolaridadunclassified
“…Electrolyte disorders known to cause collapse include hypocalcaemia,1 hypercalcaemia,2 hypokalaemia,3 hyperkalaemia,4 hyponatraemia5 and hypernatraemia 6. However, hypophosphataemia is not commonly associated with collapse, although previous reports associate hypophosphataemia with acute confusion,7 visual hallucinations8 and Wernicke’s encephalopathy 9.…”
Section: Introductionmentioning
confidence: 99%