Multiple carcinomas of the colon and rectum

Abstract

In a series of 960 cases comprising almost all cases of colorectal carcinoma diagnosed intra vitam during a 10‐year period in a defined population, there were 62 (6.5%) patients with multiple primary colorectal carcinoma. The average annual incidence was 2.6/100,000 inhabitants. Males were affected more often than females, and the frequency of patients with coexisting adenomas was higher than that in the parent series. The survival rates did not differ from those in the parent series. Synchronous lesions were seen twice as often as metachronous lesions, but the frequency of the latter is regarded as provisional. The findings suggest an interrelationship between colorectal adenoma and carcinoma. It may be concluded that every case of colorectal carcinoma requires a thorough preoperative examination of the entire large intestine. It is also concluded that all patients with colorectal carcinoma operated upon for cure should be regularly followed up for the rest of their lives for metachronous carcinomas. Cancer 33:1630–1634, 1974.

Intestinal polyps in American negroes and Nigerian africans

“…Since intestinal polyps have been shown to be interrelated to colon cancer (Ekelund and Pihl, 1974;Morson, 1971), it is not surprising that the average age for colon cancer in the African is also below 50 years (Williams and Edington, 1967), while in the American negro the peak age frequency of colon cancer is in the seventh decade (Kolade, Chung and White, 1973). Further studies are required, primarily to estimate the frequency or incidence of neoplastic polyps in population groups with low frequency of colorectal cancer and secondarily to find out factors which predispose to its development and its importance in the aetiology and pathogenesis of intestinal cancer.…”

“…Differing patterns of bacterial counts of the large intestine have been reported in East Africans, American negroes and other population groups living on different diets (Hill et al, 1970;Aries et al, 1969). There is evidence that an interrelationship exists between colorectal adenomata and carcinomata (Ekelund and Pihl, 1974;Burdette, 1971), but there are few studies on the epidemiology of colorectal adenomata in different parts of the world with varying incidences of intestinal carcinoma (Haenszel and Correa, 1971). This study analyses colorectal polyps in two population groups who are ethnologically related but have striking differences in their incidence of intestinal cancer.…”

Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: Report of a case

“…Approximately 2%-7% of colorectal carcinomas present with synchronous or metachronous tumors, 7,8 and this proportion is increasing because of the recent progress in medical treatment. However, the coexistence of primary malignant lymphoma and adenocarcinoma of the colorectum is an extremely rare event.…”

Análisis de la posible influencia de las lesiones sincrónicas en el pronóstico del cáncer colorrectal resecado

“…En la revisión bibliográfica efectuada, los trabajos referentes al posible efecto pronóstico de las lesiones neoplásicas sincróni-cas son discordantes, y en general poco actuales (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Sus discrepancias podrían explicarse en parte por el escaso núme-ro de cánceres sincrónicos que presentan la mayoría de las series y por las diferencias en cuanto a los métodos empleados para el diagnóstico y la estadificación (19).…”

“…Los estudios publicados muestran unos resultados discordantes, encontrando trabajos que confieren un pronóstico peor (11)(12)(13), similar (14)(15)(16)(17)(18)(19)(20) o mejor que el de los cánceres sin lesiones neoplásicas sincrónicas (21)(22)(23). Estas discrepancias nos han planteado realizar el presente estudio, con el objetivo de revisar una serie de parámetros relacionados con el pronóstico y la supervivencia de los pacientes, analizando sus diferencias entre dos grupos de cánceres colo-rectales con y sin lesiones sincrónicas, para valorar la posible influencia de la multicentricidad lesional con respecto al pronóstico del carcinoma de colon intervenido.…”