Multiple carcinosarcomas of the kidney: A case report and review of the literature

Öztürk, Hakan

doi:10.3892/mco.2014.411

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…Due to the complexity of the case and the lack of evidence, an MDT discussion and a careful counseling of the patient become mandatory to design further management and follow-up. Considering the very poor oncological outcomes reported in similar cases, 4,5 with the early tendency to develop metastasis, in agreement with the patient we decided to go for an adjuvant chemotherapy.…”

Section: Discussionsupporting

confidence: 62%

“…What is known from the few published cases is that regardless of the type of the primary and adjuvant treatments, the prognosis is poor, with the reported longest survival of about 2 years. 4 We present the case of a patient who has undergone a laparoscopic partial nephrectomy with a histological diagnosis of carcinosarcoma and the following management at a 3.5 years' follow-up. To the best of our knowledge, this is the second reported case of carcinosarcoma of the kidney parenchyma with malignant degeneration of both epithelial and mesenchymal components.…”

Section: Introductionmentioning

confidence: 99%

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Managing the unexpected: Carcinosarcoma of the kidney parenchyma A case with the longest follow-up

et al. 2020

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Introduction: We present the management of the second reported case of carcinosarcoma of the kidney parenchyma with malignant degeneration of both epithelial and mesenchymal components. Case report: A 36-year-old woman came to our attention for an incidental sonographic finding of a lesion in the lower pole of the left kidney. A contrasted computed tomography scan confirmed the presence of a 50 × 52 mm2 contrasted lesion in the left lower kidney pole. The patient underwent a challenging laparoscopic left partial nephrectomy and para-aortic lymphadenectomy. The histological examination led to the diagnosis of a carcinosarcoma of the kidney parenchyma with malignant degeneration of both epithelial and mesenchymal components. The patient underwent adjuvant chemotherapy with paclitaxel at 175 mg/m2 plus carboplatin area under the curve 6 intravenously for six cycles. At a follow-up of 42 months, the patient is alive and does not show any local recurrences or distant metastases. Conclusion: A multi-disciplinary therapeutic approach, combined with an adequate doctor–patient relationship and a close and detailed follow-up, is of fundamental importance in obtaining good outcomes in such rare and challenging cases.

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Managing the unexpected: Carcinosarcoma of the kidney parenchyma A case with the longest follow-up

et al. 2020

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“…The term “carcinosarcoma” or “sarcomatoid carcinoma” refers to biphasic states in which both the epithelial and sarcomatous components coexist. The frequency of carcinosarcoma is very low, less than 1% of all lung or kidney malignancies [ 31 , 32 ]. In contrast, in cases of mesothelioma, the biphasic type represents as much as 20% of all cases [ 16 – 18 ].…”

Section: Discussionmentioning

confidence: 99%

Possible reversibility between epithelioid and sarcomatoid types of mesothelioma is independent of ERC/mesothelin expression

et al. 2020

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Background: Mesothelioma is histologically divided into three subgroups: epithelioid, sarcomatoid, and biphasic types. The epithelioid or sarcomatoid type is morphologically defined by polygonal or spindle-like forms of cells, respectively. The biphasic type consists of both components. It is not yet understood how histological differentiation of mesothelioma is regulated. ERC/mesothelin is expressed in most cases of the epithelioid type, but not in the sarcomatoid type of mesothelioma. Consequently, its expression is well correlated to the histological subtype. We hypothesized that ERC/mesothelin expression influences the histological differentiation of mesothelioma, and tested this hypothesis. Methods: We performed studies using the overexpression or knockdown of ERC/mesothelin in mesothelioma cells to examine its effect on cellular morphology, growth kinetics, or migration/invasion activity, in vitro. We then transplanted ERC/mesothelin-overexpressing and control cells into the intraperitoneal space of mice. We examined the effect of ERC/mesothelin overexpression on mouse survival and tumor phenotype. Results: In vitro cell culture manipulations of ERC/mesothelin expression did not affect cellular morphology or proliferation, although its overexpression enhanced cellular adhesion and the migration/invasion activity of mesothelioma cells. The survival rate of mice following intraperitoneal transplantation of ERC/mesothelinoverexpressing mesothelioma cells was significantly lower than that of mice with control cells. The histological evaluation of the tumors, however, did not show any morphological difference between two groups, and our hypothesis was not validated. Unexpectedly, both groups (ERC/mesothelin-overexpressing and control) of mesothelioma cells that were morphologically monophasic and spindle-like in vitro differentiated into a biphasic type consisting of polygonal and spindle-like components in the transplanted tumor, irrespective of ERC/mesothelin expression. Conclusions: These results suggested that the histological transition of mesothelioma between epithelioid and sarcomatoid types may be reversible and regulated not by ERC/mesothelin, but by other unknown mechanisms.

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Biphasic malignant tumours of the abdominal cavity

et al. 2017

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Carcinosarcomas (CS) are uncommon, highly aggressive, biphasic tumours consisting of both sarcomatous and carcinomatous elements. They appear to originate from a common cell of origin, either via transformation from a single premature precursor or conversion of a mature epithelial cell through an epithelial-mesenchymal transition. CS should be considered a unique cancer subtype with cells typically displaying diffuse mitotic activity and widespread atypical mitoses predisposing to early metastasis and a tendency to local recurrence following resection. This review addresses the pathophysiology of CS and discusses its presentation, natural history and management at a variety of sites within the abdominal cavity and retroperitoneum.

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Multiple carcinosarcomas of the kidney: A case report and review of the literature

Cited by 5 publications

References 12 publications

Managing the unexpected: Carcinosarcoma of the kidney parenchyma A case with the longest follow-up

Managing the unexpected: Carcinosarcoma of the kidney parenchyma A case with the longest follow-up

Possible reversibility between epithelioid and sarcomatoid types of mesothelioma is independent of ERC/mesothelin expression

Biphasic malignant tumours of the abdominal cavity

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