Multiple Cases of Lymphoepithelioma and Burkitt�s Lymphoma in a Canadian Family1

Joncas, J H; Rioux, Émilie; Robitaille, R; Wastiaux, J. P.

doi:10.1159/000399135

Cited by 3 publications

(5 citation statements)

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“…In the previously reported families, NPC was sometimes associated with other, potentially EBVrelated malignancies (not shown in Table I), such as Burkitt's lymphoma, lymphoblastic ''sarcoma'', acute lymphoblastic leukemia and non-Hodgkin's lymphoma [4,20]. Moreover, other non-EBV-related malignancies were also detected, such as multiple myeloma, acute non-lymphocytic leukemia, brain tumor, gastric and colonic adenocarcinoma, malignant melanoma and carcinoma of the tongue and breast [4,5,20,21,24], reflecting the possible genetic susceptibility of these families to tumor development.…”

Section: Discussionmentioning

confidence: 96%

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Familial clustering of nasopharyngeal carcinoma in a non-endemic geographical region. Report of two Hungarian cases and a review of the literature

Olajos

Füle

Erfán

et al. 2005

Acta Oto-Laryngologica

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The aim of this study was to investigate the familial clustering of nasopharyngeal carcinoma (NPC) in a non-endemic geographical region on the basis of two case reports and a review of the literature. Following an upper respiratory infection, NPC (WHO type III) was detected in a 57-year-old female (Case 1) who presented with nasal symptoms and a year later in her 36-year-old son (Case 2) who presented with enlarged lymph nodes. After a full diagnostic work-up, cT2a cN0 cM0 (stage IIA; Case 1) and cT2a cN2 cM0 (stage III; Case 2) disease were identified, and telecobalt irradiation was administered to both patients. The mother achieved complete remission and has been disease-free during a 14-year follow-up period. After initial complete remission, the son experienced regional (cervical) and base of the skull relapses within 2 years, which were treated unsuccessfully by means of radical neck dissection, a second course of radiotherapy and chemotherapy. Epstein-Barr virus (EBV) was detected in pathology sections from both patients. The authors review 20 additional well-documented cases of familial clustering of NPC in non-endemic geographical regions from the English language literature. This clinical entity typically has WHO type III histology; it may occur following an upper respiratory tract infection, and EBV-related serological titers were elevated in all 20 investigated cases. No consequent promoting factors were identified. The present two cases and the review of the literature strongly suggest that familial clustering of NPC in non-endemic geographical areas may be related to EBV infections. The difference in outcome of our two cases may be explained by the fact that the disease in Case 2 was diagnosed 1 year later than that in Case 1 and hence at a more advanced stage.

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Section: Discussionmentioning

confidence: 96%

“…Moreover, other non-EBV-related malignancies were also detected, such as multiple myeloma, acute non-lymphocytic leukemia, brain tumor, gastric and colonic adenocarcinoma, malignant melanoma and carcinoma of the tongue and breast [4,5,20,21,24], reflecting the possible genetic susceptibility of these families to tumor development.…”

Section: Discussionmentioning

confidence: 99%

Familial clustering of nasopharyngeal carcinoma in a non-endemic geographical region. Report of two Hungarian cases and a review of the literature

Olajos

Füle

Erfán

et al. 2005

Acta Oto-Laryngologica

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“…The genetic landscape of Burkitt lymphoma (BL) has been elucidated over decade, however, few reports have described genetic basis for its pathogenesis in familial BL. [1][2][3][4][5] Here, we performed targeted deep next generation sequencing of Japanese dizygotic twins who were diagnosed with BL (Figure S1A).…”

Section: Targeted Deep Next Generation Sequencing Identifies Potential Somatic and Germline Variants For Predisposition To Familial Burkimentioning

confidence: 99%

Targeted deep next generation sequencing identifies potential somatic and germline variants for predisposition to familial Burkitt lymphoma

Okabe¹,

Morishita²,

Yasuda

et al. 2021

European J of Haematology

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“…There is one previous report of NPC in a parent and BL in a child (Li, 1976), and multiple cases of both BL and NPC within one family were recorded in one of the papers cited earlier (Joncas et al, 1976). BL and NPC are both linked epidemiologically with Epstein-Barr virus (EBV) though the nature of the association remains uncertain (de-ThC et al, 1978;Epstein, 1978).…”

Section: Familial Association Of Bl and Npcmentioning

confidence: 99%

“…There have been a few reports of BL in related individuals from Africa and from <<non-endemic>> areas (Dalldorf et al, 1964, Morrow et al, 1971Stevens et al, 1972;Clifford, personal communication, 1973;Joncas et al, 1976;Williams et al, 1978;Ziegler, personal communication, 1979) but it has been impossible to assess whether these were chance occurrences or indicated an increased susceptibility or exposure to causative agent(s) among members of the same family.…”

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confidence: 99%

Multiple cases of Burkitt's lymphoma and other neoplasms in families in the north mara district of Tanzania

Brubaker¹,

Levin

Steel

et al. 1980

Intl Journal of Cancer

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In an area of Tanzania in which Burkitt's lymphoma (BL) is endemic, five families are described in which multiple cases of BL were found or BL occurred with other neoplasms. The patients include two brothers and one half-brother with BL, two brothers with BL, a woman with nasopharyngeal carcinoma (NPC) whose daughter had BL, a boy with BL whose sister developed chronic myelogenous leukaemia (CML), and a man with CML whose son developed BL. The two full-sib pairs with BL is significantly more than would be expected to have arisen by chance and the association of BL with NPC and CML among close relatives is remarkable in view of the rarity of the last two neoplasms in the study area. It is suggested that genetic factors may be important. It is suggested that genetic factors may be important in determining susceptibility to the three malignancies in this population, but the possibility that the clustering of cases within families may be due to local environmental factors cannot be excluded.

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Multiple Cases of Lymphoepithelioma and Burkitt�s Lymphoma in a Canadian Family1

Cited by 3 publications

References 0 publications

Familial clustering of nasopharyngeal carcinoma in a non-endemic geographical region. Report of two Hungarian cases and a review of the literature

Familial clustering of nasopharyngeal carcinoma in a non-endemic geographical region. Report of two Hungarian cases and a review of the literature

Targeted deep next generation sequencing identifies potential somatic and germline variants for predisposition to familial Burkitt lymphoma

Multiple cases of Burkitt's lymphoma and other neoplasms in families in the north mara district of Tanzania

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