Multiple chondromatous hamartomas of the lung

Abstract

Multiple chondromatous hamartomas (MCH) of the lung are very rare: only 16 cases have been reported to date. In young women, the tumours may be a manifestation of Carney triad (gastric leiomyoblastoma, pulmonary hamartoma and extra-adrenal paraganglioma) or Cowden syndrome (mucocutaneous lesions, multiple benign tumors of internal organs and increased risk for breast, thyroid, urogenital and digestive tract cancer). We report the 17th case of MCH of the lung, diagnosed accidentally in a 66 year-old male patient, with suspected concomitant hamartomas and malignant tumours.

Pulmonary Hamartomas: A Report of 13 Parenchymal and Endobronchial Cases

“…Bini et al (11) reported that transthoracic fine needle aspiration biopsy did not establish diagnosis in their case. Hansen et al (12) observed that preoperative diagnosis from transthoracic needle aspiration could be obtained in 85% of the patients with pulmonary hamartoma.…”

“…Pathologic diagnosis of pulmonary hamartomas can be obtained surgical or preoperative methods such as bronchoscopy or transthoracic needle biopsy (3,8,11,12). Bini et al (11) reported that transthoracic fine needle aspiration biopsy did not establish diagnosis in their case.…”

Multiple Pulmonary Chondroid Hamartoma

“…It is well known that harmatomas are composed of tissue elements normally found at that site, but which are growing in a disorganized mass, usually seem as single, round nodules with distinct boundaries. 1 A cytogenetic analysis of the pulmonary hamartomas showed an abnormal karyotype and revealed recombinations between chromosomal bands 6p21 and 14q24, 2 which supported that a hamartoma of the lung was a true neoplasm. Solitary pulmonary hamartoma is a common benign tumor that is usually seen in males, whereas multiple pulmonary hamartomas are rare and predominate in females.…”

“…5 Generally speaking, a non-anatomical resection is curative for a benign lesion although the location of the lesion plays an important role in the decision of surgical type. 1 Video-assisted thoracic surgery now seems to be a trend in dealing with benign tumors because of less morbidity of surgical complications and hospital stay compared with traditional thoracotomy. On the other hand, endobronchial hamartomas can be well managed by endoscopy and laser ablation.…”

Novel platinum agents and mesenchymal stromal cells for thoracic malignancies: state of the art and future perspectives

“…It can occur at any place where mesothelial cells de-differentiate from mesenchymal cells, including the pericardium, peritoneum, tunica vaginalis of the ovary and testis, although both pleurae (visceral and parietal pleura) are the most common affected structures. 8,9 The incidence of MPM in in Japan and Europe are projected to peak in 2025 and 2020 respectively, while the incidence in the USA has remained stable at 3000 deaths per year since peaking in 2004. 10 Surgical resection is the best therapeutic approach in early stages MPM (I, II and selected N0 stage III) without distant diffusion as well as radiotherapy as complementary or symptomatic treatment.…”