Multiple congenital infantile hemangiomas of the lung in partial trisomy D

Quijano, Graciela; Drut, Ricardo

doi:10.1136/jcp.2005.033522

Cited by 14 publications

(8 citation statements)

References 10 publications

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“…Among these 4 cases, 3 children presented with associated malformations, such as cardiac or genital malformations, 3,4 and 1 in the setting of trisomy 13. 5 Our patient presented with cardiac and renal malformations. To our knowledge, this is the first case of IH associated with renal malformation.…”

Section: Discussionmentioning

confidence: 82%

“…Lung involvement is extremely rare: only 4 previous cases with GLUT-1 positive staining have been reported to date (Table 1). [2][3][4][5] Cases without GLUT-1 immunostaining were excluded from this review.…”

Section: Discussionmentioning

confidence: 99%

“…It is also noticeable that gestational diabetes occurred in 2 cases of lung IH including ours 2 and preeclampsia/hypertension in 2 other cases. 4,5 Placental abnormalities such as placenta praevia and preeclampsia are frequently reported in IH cases. 14 Prematurity, multiple gestation, and advanced maternal age are also considered as predisposing factors of IH.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, extra cutaneous locations, especially pulmonary IH are extremely rare, with only a few cases reported in the literature. [2][3][4][5][6] We report here a case of pulmonary IH associated with congenital heart defect and renal malformation in a young boy.…”

Section: Introductionmentioning

confidence: 90%

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Pulmonary Infantile Hemangioma Mimicking a Congenital Cystic Adenomatoid Malformation

et al. 2019

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Infantile hemangioma (IH) is the most common benign vascular tumor of infancy, occurring predominantly in the head and neck. It is characterized by specific endothelial expression of glucose transporter-1 (GLUT-1) and involution with time, spontaneous or on beta-blockers treatment. Although some predisposing factors are known, the exact pathogenesis remains unclear. We report a case of pulmonary IH GLUT-1 positive, initially suspected as a cystic pulmonary airway malformation, in a child presenting with both cardiac and renal malformations. The clinical, radiological, pathological, and genetics findings are discussed with a review of the literature. Although pulmonary IH is a rare lesion, it should be suspected when facing a pulmonary cystic mass in a child.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

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Pulmonary Infantile Hemangioma Mimicking a Congenital Cystic Adenomatoid Malformation

et al. 2019

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“…In addition, white women with a family history of infantile hemangiomas, particularly those with a first-degree relative, are also at higher risk [5,6]. Although infantile hemangiomas are common, pulmonary infantile hemangiomas are exceedingly rare, with only a few case reports in the literature [3,[8][9][10] (Table 1). We present a case of pulmonary infantile hemangioma in a premature male infant successfully managed by surgical excision.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Infantile Hemangioma Presenting as a Mass in a Premature Male Infant: A Case Report Focusing on Pathological Features

et al. 2015

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Infantile hemangiomas are the most common benign neoplasm of infancy, with most occurring in the head and neck region. Predisposing factors include prematurity, low birth weight, multiple gestations, advanced maternal age, and chorionic villous sampling. In addition, white women, particularly those with a family history, are also at a higher risk. However, pulmonary infantile hemangiomas are exceedingly rare, with only a few case reports in the literature. Infantile hemangiomas should be considered in the differential diagnosis of a pulmonary mass in the early pediatric population. We present a case of pulmonary infantile hemangioma in a premature male infant successfully managed by surgical excision, with an emphasis on the pathogenesis and histologic features.

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A tumor profile in Patau syndrome (trisomy 13)

Satgé¹,

Nishi

Sirvent

et al. 2017

American J of Med Genetics Pt A

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Individuals with trisomic conditions like Down syndrome and Edwards syndrome are prone to certain types of malignancy. However, for Patau syndrome (constitutional trisomy 13), which occurs in 1/10,000-1/20,000 live births, the tumor profile has not been well characterized. An awareness of susceptibility to malignancies can improve care of affected individuals, as well as further our understanding of the contribution of trisomy to carcinogenesis. Therefore, we conducted an extensive review of the literature; we found 17 malignancies reported in individuals with Patau syndrome. These comprised eight embryonic tumors, three leukemias, two malignant germ cell tumors, two carcinomas, a malignant brain tumor, and a sarcoma. Benign tumors were mainly extragonadal teratomas. The small number of reported malignant tumors suggests that there is not an increased risk of cancer in the context of trisomy 13. The tumor profile in Patau syndrome differs from that observed in Edwards syndrome (trisomy 18) and Down syndrome (trisomy 21), suggesting that the supernumerary chromosome 13 could promote particular tumor formations as it does particular malformations. No general and direct relationships of tumor occurrence with organ weight, congenital malformations, histological changes, or presence of tumor suppressor genes on chromosome 13 were observed. However, some tumors were found in tissues whose growth and development are controlled by genes mapping to chromosome 13. Recent reports of successful outcomes following surgical treatment and adapted chemotherapy indicate that treatment of cancer is possible in Patau syndrome.

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Multiple congenital infantile hemangiomas of the lung in partial trisomy D

Cited by 14 publications

References 10 publications

Pulmonary Infantile Hemangioma Mimicking a Congenital Cystic Adenomatoid Malformation

Pulmonary Infantile Hemangioma Mimicking a Congenital Cystic Adenomatoid Malformation

Pulmonary Infantile Hemangioma Presenting as a Mass in a Premature Male Infant: A Case Report Focusing on Pathological Features

A tumor profile in Patau syndrome (trisomy 13)

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