Multiple cutaneous neurilemmomas as a skin manifestation of neurilemmomatosis

Multiple schwannomas in the peripheral nerves

“…Some of these series included patients who would now be classified as having NF2, but others had multiple schwannomas with no evidence of NF. 8,[11][12][13][14][15][16] The reported lesions were usually less than 5 cm in diameter and were usually superficial, but our patients tended to have larger tumours which were situated deeper. Histologically, it is sometimes difficult to differentiate in a small biopsy between a benign schwannoma and malignant tumours such as MPNST, fibrosarcoma or a leiomyosarcoma.…”

A Rare Peripheral Nerve Tumour ‘Schwannoma’ In the Breast: A Case Report.

“…However, in the present study multipleSchwannomas are beingreported from two different sites of the same patient one from right female breast which is considered to be the most rare location of Schwannoma [2,3,5,6,8,9] and another from right upper arm considered usually a common sites. Its uncommon intra mammary location is confirmed from the fact that during the past oneyear from June 2010-June 2011, in our clinic we have come across a single case of Schwannoma of breast out of 30 breast nodules studied for the different pathological conditions and only one present case of two schwannomas at two different sites of the patient.Earlier only afew cases of such occurrences of multiple Schwannomas have been reported [10]. Breast Schwannomashave not only been reported fromfemales but in certain cases from elderly men also [4].…”

Multiple schwannomas, multiple nevi, and multiple vaginal leiomyomas: A new dominant syndrome

“…Neurilemomatosis (multiple schwannomas) was a term coined by Shishiba et al [1984] to refer to mul- tiple nerve sheath tumors distinct from autosomal dominant neurofibromatosis. Most affected patients are sporadic cases, but there have been a few familial cases [Iwabuchi et al, 1993;Yamazaki et al, 1988].…”

“…Most affected patients are sporadic cases, but there have been a few familial cases [Iwabuchi et al, 1993;Yamazaki et al, 1988]. Some multiple cutaneous neurilemomas have been associated with vestibular schwannomas (rarely with other cranial nerves) and brain stem and spinal cord tumors, meningiomas, gliomas, and viscera, suggesting a relationship with neurofibromatosis, type 2 (NF-2) [Shishiba et al, 1984;Iwabuchi et al, 1993;Reith and Goldblum, 1996]. However, café-au-lait spots and neurofibromas were not seen.…”

“…The schwannomas are scattered involving sensory and motor nerves, most being relatively superficial [Nödl, 1958;Shishiba et al, 1984]. A number of linear cutaneous neurilemomas have been reported [Altmeyer, 1979;Tanaka et al, 1991;Buenger et al, 1993;Portneuf et al, 1993;Thomas et al, 1995].…”