Multiple Dermatofibromas in Patients with Systemic Lupus Erythematosus on Immunosuppressive Therapy

Multiple Clustered Dermatofibromas

“…The young age of the patients at the time of the onset of the lesions is to be noted (4, 13 and 15 years). Five cases of multiple histiocytofibromas have been reported in patients with an auto immune disease that were being treated with immunosuppressors [11,12], These cases, perhaps, showed no tendency toward group ing. No evidence for an impaired immunity was found in our patient.…”

A Case of Idiopathic Dermatofibromatosis

“…5 MED tanısı ile bildirilen olgularda eşlik eden otoimmün hastalıklar arasında SLE, Sjögren sendromu, miyasteni gravis, pemfigus vulgaris, dermatomiyozit gibi hastalıklar bildirilmiştir. [14][15][16][17][18][19][20][21] Ayrıca HIV enfeksiyonu, atopik dermatit, miyelodisplastik sendrom ve gebelik ilişkilendirilen diğer durumlardır. İyatrojenik immünsupresyon vakalarında da MED gelişimi bildirilmiştir.…”

Involvement of Basic Fibroblast Growth Factor in Fibroblast-Stimulatory Serum Activity of a Patient with Systemic Lupus erythematosus and Multiple Dermatofibromas

“…DF usually occurs as a solitary lesion, while multiple DFs arise in close association with autoimmune diseases such as SLE [1][2][3][4][5], especially under immunosuppressive therapy, though the exact mechanisms underlying their occurrence remain unknown. An increased number of mast cells is often observed in the portion between the DF lesion and the overlying epidermis, especially in the case of an early-onset lesion [7], Furthermore, decreasing or fading DFs are rarely seen in the course of original disorders, and the mast cell numbers of these fading DFs are decreased [7|.…”

“…Although dermatofibroma (DF) has been considered to be a reactive hyperplasia rather than a true neoplasm, the issue remains unsettled [1). DF is a common and benign dermal nodule which usually occurs as a solitary lesion or …”