Multiple Disease Associations in Autoimmune Polyglandular Syndrome Type II

Adrenal crisis is the most severe manifestation of adrenal insufficiency (AI), but AI can present with variable signs and symptoms of gradual severity. Despite current hormone replacement strategies, adrenal crisis is still one of the leading causes of mortality in AI patients. Although underlying factors explaining differences in interindividual susceptibility are not completely understood, several subgroups are particularly vulnerable to adrenal crises, such as patients with primary AI, and patients treated for Cushing’s syndrome. Currently, the health care professional faces several challenges in the care for AI patients, including the lack of reliable biomarkers measuring tissue cortisol concentrations, absence of a universally used definition for adrenal crisis, and lack of clinical tools to identify individual patients at increased risk. Also from the patient’s perspective, there are a number of steps to be taken in order to increase and evaluate self-management skills and, finally, improve health-related quality of life (HR-QoL). In this respect, the fact that inadequate handling of AI patients during stressful situations is a direct consequence of not remembering how to act due to severe weakness and cognitive dysfunction in the context of the adrenal crisis is quite underexposed. In this narrative review, we give an overview of different clinical aspects of adrenal crisis, and discuss challenges and unmet needs in the management of AI and the adrenal crisis from both the doctor’s and patient’s perspective. For the latter, we use original focus group data. Integration of doctor’s and patient’s perspectives is key for successful improvement of HR-QoL in patients with AI.

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Beyond skin white spots: Vitiligo and associated comorbidities

Wang

2023

Front. Med.

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Vitiligo is a common depigmentation disorder of an unknown origin characterized by the selective loss of melanocytes, resulting in typical white macules and patches. However, vitiligo is now recognized as more than just a skin disease, what a dermatologist observes as a white spot of skin is just the “tip of the iceberg” of the condition. We attempt to clarify the classification of comorbidities associated with vitiligo from various reviews and reports, and describe their possible pathogenesis. In conclusion, the literature provides evidence of an association between vitiligo and ocular and auditory abnormalities, autoimmune disorders, other dermatological diseases, metabolic syndrome and related disorders, and psychological diseases. These associations highlight the importance of a multidisciplinary approach in managing vitiligo patients.

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Multiple Disease Associations in Autoimmune Polyglandular Syndrome Type II

Cited by 3 publications

References 15 publications

Endocrine complications of celiac disease: a case report and review of the literature

Endocrine complications of celiac disease: a case report and review of the literature

Clinical Unmet Needs in the Treatment of Adrenal Crisis: Importance of the Patient’s Perspective

Beyond skin white spots: Vitiligo and associated comorbidities

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