Multiple-Domain Predictors of Problematic Alcohol Use in Young Adulthood

Kramer, John; Chan, Grace; Dick, Danielle M.; Kuperman, Samuel; Bucholz, Kathleen K.; Edenberg, Howard J.; Polgreen, Linnea A.; Hesselbrock, Victor; Schuckit, Marc A.; Nürnberger, John I.; Kapp, Ellen S.; Porjesz, Bernice; Bierut, Laura J.

doi:10.15288/jsad.2008.69.649

Cited by 33 publications

(21 citation statements)

References 69 publications

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“…It would be interesting to evaluate whether the candidate genes (e.g. GABRA2 [48] , CHRM2 [49] and MAOA [50] ) that have been implicated in familial risk for externalizing disorders might play a role in affecting both cognitive control and BMI in adolescents. A future study will examine this question.…”

Section: Discussionmentioning

confidence: 99%

P300 and the Stroop Effect in Overweight Minority Adolescents

Bauer

Kaplan²,

Hesselbrock³

2010

Neuropsychobiology

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Aim: The goal was to examine the relationship between a risk factor for poor cognitive control and a health outcome of growing public significance – an excess body mass – among adolescents. Methods: To this end, 109 adolescents aged 14–20 years were recruited and assigned to 1 of 4 groups defined by the crossing of the absence versus presence of a parental history (PH) of externalizing disorders with a body mass index (BMI) percentile (BMIP) <85 versus ≧85. The principal measure estimating cognitive control was the P300 event-related electroencephalographic response recorded during the Stroop task. Results: The analyses revealed a synergistic interaction between BMIP rank, PH and trial type: the increase in P300 latency and the decrease in response accuracy, elicited by the presence of interfering information, were markedly greater in high-BMIP subjects with a PH of externalizing disorders than in the other subject groups. Analyses of a later component, the N450, previously associated with the Stroop interference effect, revealed no effect of BMI or PH. Conclusions: We conclude that subjects with both a PH of externalizing disorders and an excess BMI constitute a unique group that is less able to resolve cognitive conflict than others. The excessive delay in P300 evoked by conflicting response demands in these subjects may be a marker of a heritable factor that increases risk for both excess body mass and substance use disorders.

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Section: Discussionmentioning

confidence: 99%

P300 and the Stroop Effect in Overweight Minority Adolescents

Bauer

Kaplan²,

Hesselbrock³

2010

Neuropsychobiology

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“…It has been reported that a consistent elevation in the risk for alcohol dependence associated with GABRA2 is not apparent until the mid-20s and then remains constant throughout adulthood (Dick, et al, 2006b; Kramer, et al, 2008). A gene-environment correlation and a gene-environment interaction associated with GABRA2 , marital status and alcohol dependence have been reported, suggesting that GABRA2 interacts with environmental factors and life style in determining the risk for alcohol dependence (Dick, et al, 2006a).…”

Section: Gabra2 and Alcohol Dependencementioning

confidence: 99%

α2-containing GABAA receptors: A target for the development of novel treatment strategies for CNS disorders

Engin

Liu

Rudolph

2012

Pharmacology & Therapeutics

123

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GABAA receptors have important physiological functions, as revealed by pharmacological studies and experiments involving gene-targeted mouse models, and are the target of widely used drugs such as the benzodiazepines. In this review, we are summarizing current knowledge about the function of α2-containing GABAA receptors, a receptor subtype representing approximately 15–20% of all GABAA receptors. This receptor subtype mediates anxiolytic-like, reward-enhancing, and antihyperalgesic actions of diazepam, and has antidepressant-like properties. Secondary insufficiency of α2-containing GABAA receptors has been postulated to play a role in the pathogenesis of schizophrenia, and may be involved in cognitive impairment in other disorders. Moreover, polymorphisms in the GABRA2 gene encoding the GABAA receptor α2 subunit have been found to be linked to chronic alcohol dependence and to polydrug abuse. Thus, α2-containing GABAA receptors are involved in the regulation and/or modulation of emotional behaviors and of chronic pain, and appear to be a valid target for novel therapeutic approaches for the treatment of anxiety, depression, schizophrenia and chronic pain.

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“…COGA has used a variety of strategies to aid in gene identifi cation, including the use of rich phenotyping to characterize genetic effects (Dick et al, 2013b;Kramer et al, 2008), as well as electrophysiological endophenotypes (Begleiter & Porjesz, 1999;Dick et al, 2006b). In addition, the study has used a variety of genetic designs and methodologies.…”

mentioning

confidence: 99%

Genes Associated With Alcohol Outcomes Show Enrichment of Effects With Broad Externalizing and Impulsivity Phenotypes in an Independent Sample

Alıev

Wetherill

Bierut

et al. 2015

J. Stud. Alcohol Drugs

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ABSTRACT. Objective:The purpose of this study was to evaluate evidence for association with a panel of genes previously associated with alcohol-related traits in a new sample of adolescent and young adult individuals (N = 2,128; 51% female) collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). We tested for association with phenotypes related to externalizing behavior, including diagnostic symptom counts for disorders on the externalizing spectrum (alcohol dependence, conduct disorder, adult antisocial personality disorder, and illicit drug dependence), and related behavioral/personality traits (Achenbach Externalizing, NEO Extraversion, NEO Conscientiousness, Zuckerman's Sensation Seeking, and the Barratt Impulsivity Scale) based on the substantial literature suggesting that these behaviors may be alternate manifestations of a shared genetic liability. Method: We tested for overall enrichment of the set of 215 genotyped single-nucleotide polymorphisms (SNPs) for each of the phenotypes. We conducted secondary analyses comparing results for sensation seeking with results for the other phenotypes. Results: For all phenotypes, there was significant enrichment of association results (p < .05) compared with chance expectations. The greatest number of signifi cant results was observed with the phenotype Sensation Seeking. Secondary analyses indicated that the number of SNPs yielding p < .05 with Sensation Seeking was signifi cantly greater than that observed for each of the other phenotypes. Conclusions: We fi nd evidence for enrichment of association results across a spectrum of externalizing phenotypes with a panel of candidate genes/SNPs selected based on previous suggestion of association with alcohol-related outcomes. In particular, we fi nd signifi cant enrichment of effects with sensation seeking, suggesting that this may be a particularly salient behavior associated with risk for alcohol-related problems. (J.

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Multiple-Domain Predictors of Problematic Alcohol Use in Young Adulthood

Cited by 33 publications

References 69 publications

P300 and the Stroop Effect in Overweight Minority Adolescents

P300 and the Stroop Effect in Overweight Minority Adolescents

α2-containing GABAA receptors: A target for the development of novel treatment strategies for CNS disorders

Genes Associated With Alcohol Outcomes Show Enrichment of Effects With Broad Externalizing and Impulsivity Phenotypes in an Independent Sample

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