Multiple dose pharmacokinetics of caffeine administered in chewing gum to normal healthy volunteers

Syed, S.; Kamimori, Gary H.; Kelly, William F.; Eddington, Natalie D.

doi:10.1002/bdd.469

Cited by 48 publications

(30 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…marksmanship), it has generally been concluded that caffeine enhances operational capabilities (McLellan et al, 2005a(McLellan et al, , 2005bTikuisis et al, 2004). This conclusion has prompted researchers to develop new methods, deemed more suitable than beverages, for delivering caffeine to personnel during active operations, and chewing gum has emerged as the preferred delivery vehicle (Kamimori et al, 2002;LaJambe et al, 2005;Syed et al, 2005).…”

Section: Caffeine Use In Military Operationsmentioning

confidence: 98%

Caffeine, sleep and wakefulness: implications of new understanding about withdrawal reversal

James

Keane²

2007

Human Psychopharmacology

View full text Add to dashboard Cite

The broad aim of this review is to critically examine the implications of new understanding concerning caffeine withdrawal and withdrawal reversal in the context of research concerned with the effects of caffeine on sleep and wakefulness. A comprehensive search was conducted for relevant experimental studies in the PubMED and PsycINFO databases. Studies were assessed with particular reference to methodological adequacy for controlling against confounding due to caffeine withdrawal and withdrawal reversal. This assessment was used to clarify evidence of effects, highlight areas of ambiguity and derive recommendations for future research. It was found that researchers have generally failed to take account of the fact that habitual use of caffeine, even at moderate levels, leads to physical dependence evidenced by physiological, behavioural and subjective withdrawal effects during periods of abstinence. Consequently, there has been near-complete absence of adequate methodological controls against confounding due to reversal of withdrawal effects when caffeine is experimentally administered. The findings of what has been a substantial research effort to elucidate the effects of caffeine on sleep and wakefulness, undertaken over a period spanning decades, are ambiguous. Current shortcomings can be redressed by incorporating suitable controls in new experimental designs.

show abstract

Section: Caffeine Use In Military Operationsmentioning

confidence: 98%

Caffeine, sleep and wakefulness: implications of new understanding about withdrawal reversal

James

Keane²

2007

Human Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…The concentration of caffeine in the body is modeled using a simplified convolution integral of an input and an elimination process ( Johnson and Straume, 1999; Johnson and Veldhuis, 1995; Syed et al ., 2005 Veldhuis et al ., 1987). The input process is approximated as an instantaneous dose i at time T i (the time of mastication), which allows the unbounded integral to be written as a sum of doses, one to N = 12.…”

Section: Methodsmentioning

confidence: 99%

Chapter 16 Modeling Fatigue over Sleep Deprivation, Circadian Rhythm, and Caffeine with a Minimal Performance Inhibitor Model

Benitez

Kamimori

Balkin

et al. 2009

Methods in Enzymology

Self Cite

View full text Add to dashboard Cite

Sleep loss, as well as concomitant fatigue and risk, is ubiquitous in today’s fast-paced society. A biomathematical model that succeeds in describing performance during extended wakefulness would have practical utility in operational environments and could help elucidate the physiological basis of sleep loss effects. Eighteen subjects (14 males, 4 females; age 25.8 ± 4.3 years) with low levels of habitual caffeine consumption (<300 mg/day) participated. On night 1, subjects slept for 8 h (2300–0700 h), followed by 77 h of continuous wakefulness. They were assigned randomly to receive placebo or caffeine (200 mg, i.e., two sticks of Stay Alert gum) at 0100, 0300, 0500, and 0700 during nights 2, 3, and 4. The psychomotor vigilance test (PVT) was administered periodically over the 77-h period of continuous wakefulness. Statistical analysis reveals lognormality in each PVT, allowing for closed-form median calculation. An iterative parameter estimation algorithm, which takes advantage of MatLab’s (R2007a) least-squares nonlinear regression, is used to estimate model parameters from subjects’ PVT medians over time awake. In the model, daily periodicity is accounted for with a four-component Fourier series, and a simplified binding function describes asymptotic fatigue. The model highlights patterns in data that suggest (1) the presence of a performance inhibitor that increases and saturates over the period of continuous wakefulness, (2) competitive inhibition of this inhibitor by caffeine, (3) the persistence of an internally driven circadian rhythm of alertness, and (4) a multiplicative relationship between circadian rhythm and performance inhibition. The present inhibitor-based minimal model describes performance data in a manner consistent with known biochemical processes.

show abstract

“…Caffeine acts as a mild psycho-stimulant, being able to re-establish the alertness and performance capacity in subjects experiencing fatigue [1, 11]. The hepatic metabolism produces active metabolites (paraxanthine, theophylline, and theobromine) that contribute to pharmacologic effects [1, 11–13]. Caffeine contributes to competitive inhibition of phosphodiesterase by inactivating the cyclic adenosine monophosphate.…”

Section: Introductionmentioning

confidence: 99%

Bioequivalence and Pharmacokinetic Evaluation Study of Acetaminophen vs. Acetaminophen Plus Caffeine Tablets in Healthy Mexican Volunteers

Guzmán¹,

Ruiz‐Molina²,

Núñez³

et al. 2016

Drugs R D

View full text Add to dashboard Cite

ObjectiveThe aim of this clinical trial was to establish the bioequivalence of two tablets containing acetaminophen 650 mg (reference) and acetaminophen 650 mg plus caffeine 65 mg (test), administered orally, in fasting conditions in healthy Mexican volunteers.MethodsBlood samples were taken from 21 male and five female individuals, during a 24-h period, to characterize the pharmacokinetic profile of acetaminophen. Plasma samples were quantified by ultra-performance liquid chromatography, tandem mass spectrometry. Pharmacokinetic metrics (maximum plasma concentration, area under the curve from time zero to the last sampling time, and area under the curve from time zero to infinity) were used to determine the 90 % confidence interval of the test/reference coefficient.ResultsThe geometric mean values for maximum plasma concentration obtained for the reference and test products were 9.46 ± 34.21 and 9.72 ± 32.38 µg/mL, respectively, whereas for the area under the curve from time zero to the last sampling time the values obtained were 34.93 ± 32.58 and 35.89 ± 31.03 µg h/mL for the reference and test formulations, respectively. The 90 % confidence intervals were within the acceptance range (80–125 %).ConclusionsThe test product was bioequivalent to the reference product. A faster absorption was seen in the test formulation in the Mexican population.

show abstract

Multiple dose pharmacokinetics of caffeine administered in chewing gum to normal healthy volunteers

Cited by 48 publications

References 8 publications

Caffeine, sleep and wakefulness: implications of new understanding about withdrawal reversal

Caffeine, sleep and wakefulness: implications of new understanding about withdrawal reversal

Chapter 16 Modeling Fatigue over Sleep Deprivation, Circadian Rhythm, and Caffeine with a Minimal Performance Inhibitor Model

Bioequivalence and Pharmacokinetic Evaluation Study of Acetaminophen vs. Acetaminophen Plus Caffeine Tablets in Healthy Mexican Volunteers

Contact Info

Product

Resources

About