Multiple-Drug Resistance in
            <scp>d</scp>
            -Tartrate-Positive
            <i>Salmonella enterica</i>
            Serovar Paratyphi B Isolates from Poultry Is Mediated by Class 2 Integrons Inserted into the Bacterial Chromosome

Miko, Angelika; Pries, Karin; Schroeter, Andreas; Helmuth, Reiner

doi:10.1128/aac.47.11.3640-3643.2003

Cited by 41 publications

(33 citation statements)

References 30 publications

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“…Poultry-associated multidrug-resistant strains harbored a class 2 integrase gene. In combination with dfrA1, sat1 (Tn7), and aadA1, this indicated that a class 2 integron was carried by these strains, as previously described by Miko et al (28). Additionally, six strains had a class 1 integrase gene in combination with sul1.…”

supporting

confidence: 79%

“…Cluster A contained 32 strains of the 108 strains (30%), cluster B contained 43 strains (40%), and cluster C contained 33 strains (31%). XbaI profile number 60 harbored 20 strains of the 33 strains (61%) in cluster C and was previously described as an X8 profile (21,28). These strains were isolated from poultry/poultry meat, other livestock, and humans but not from reptiles.…”

mentioning

confidence: 99%

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Human Infections Attributable to thed-Tartrate-Fermenting Variant of Salmonella enterica Serovar Paratyphi B in Germany Originate in Reptiles and, on Rare Occasions, Poultry

Toboldt

Helmuth

Fruth

et al. 2012

Appl Environ Microbiol

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In this study, the population structure, incidence, and potential sources of human infection caused by the D-tartrate-fermenting variant of Salmonella enterica serovar Paratyphi B [S. Paratyphi B (DT؉)] was investigated. In Germany, the serovar is frequently isolated from broilers. Therefore, a selection of 108 epidemiologically unrelated S. enterica serovar Paratyphi B (DT؉) strains isolated in Germany between 2002 and 2010 especially from humans, poultry/poultry meat, and reptiles was investigated by phenotypic and genotypic methods. Strains isolated from poultry and products thereof were strongly associated with multilocus sequence type ST28 and showed antimicrobial multiresistance profiles. Pulsed-field gel electrophoresis XbaI profiles were highly homogeneous, with only a few minor XbaI profile variants. All strains isolated from reptiles, except one, were strongly associated with ST88, another distantly related type. Most of the strains were susceptible to antimicrobial agents, and XbaI profiles were heterogeneous. Strains isolated from humans yielded seven sequence types (STs) clustering in three distantly related lineages. The first lineage, comprising five STs, represented mainly strains belonging to ST43 and ST149. The other two lineages were represented only by one ST each, ST28 and ST88. The relatedness of strains based on the pathogenicity gene repertoire (102 markers tested) was mostly in agreement with the multilocus sequence type. Because ST28 was frequently isolated from poultry but rarely in humans over the 9-year period investigated, overall, this study indicates that in Germany S. enterica serovar Paratyphi B (DT؉) poses a health risk preferentially by contact with reptiles and, to a less extent, by exposure to poultry or poultry meat.

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supporting

confidence: 79%

mentioning

confidence: 99%

Human Infections Attributable to thed-Tartrate-Fermenting Variant of Salmonella enterica Serovar Paratyphi B in Germany Originate in Reptiles and, on Rare Occasions, Poultry

Toboldt

Helmuth

Fruth

et al. 2012

Appl Environ Microbiol

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“…Goldstein et al reported an occurrence of 5% (7/129) in Salmonella isolates (Goldstein et al, 2001). In Germany, 85 contemporary multi-drug resistant D-Tartrate-Positive S. enterica Serovar Paratyphi B isolates were found to possess class 2 integron with dfrA1-sat1-aadA1 array of gene cassettes between 1995 and 2001 (Miko et al, 2003). In Uruguay, 26 out of 258 strains of S. Typhimurium were found to carry class 2 integron between 1976 and 2000 (Macedo-Vinas et al, 2009).…”

Section: Class 2 Integronmentioning

confidence: 99%

Role of integrons in antimicrobial resistance: A review

Gao¹,

Li²,

Liu³

et al. 2013

Afr. J. Microbiol. Res.

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Antibiotic resistance in bacteria still remains one of the leading concerns in global public health. Horizontal transfer of resistance genes is considered to be a major cause to facilitate the rapid spread of antibiotic resistance in microbes. In recent years, the role of integrons as mobile genetic elements playing a central role in horizontal transfer of antibiotic resistance have been well studied and documented. Nevertheless, up to date, most of the available investigations and studies on integron had focused on class 1 integrons of Gram-negative microorganisms. In the last decade, class 4 integrons (also known as super integrons) has been considered a major concern in antimicrobial resistance, as well as, a significant factor in bacterial genome evolution; however, most reports had been limited to Vibrio. Thus, this review is aimed at summarizing the occurrence and prevalence of integrons in bacterial isolates, with the focus on class 1 integron within Gram-positive bacteria, class 2 and 3 integrons.

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“…However, all of these studies were concerned with class 1 integrons, with no exception. Class 2 integrons were most frequently associated with members of the family Enterobacteriaceae, such as Escherichia coli and Salmonella enterica, and also are commonly found in Acinetobacter baumannii and Burkholderia cepacia (1,3,4,19,25,27,37). However, class 2 integrons in P. aeruginosa had never been reported.…”

mentioning

confidence: 99%

Occurrence and Characteristics of Class 1 and 2 Integrons in Pseudomonas aeruginosa Isolates from Patients in Southern China

Shirtliff

et al. 2009

J Clin Microbiol

137

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Multiple-Drug Resistance in d -Tartrate-Positive Salmonella enterica Serovar Paratyphi B Isolates from Poultry Is Mediated by Class 2 Integrons Inserted into the Bacterial Chromosome

Cited by 41 publications

References 30 publications

Human Infections Attributable to thed-Tartrate-Fermenting Variant of Salmonella enterica Serovar Paratyphi B in Germany Originate in Reptiles and, on Rare Occasions, Poultry

Human Infections Attributable to thed-Tartrate-Fermenting Variant of Salmonella enterica Serovar Paratyphi B in Germany Originate in Reptiles and, on Rare Occasions, Poultry

Role of integrons in antimicrobial resistance: A review

Occurrence and Characteristics of Class 1 and 2 Integrons in Pseudomonas aeruginosa Isolates from Patients in Southern China

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