Multiple effects of green tea catechin on the antifungal activity of antimycotics against Candida albicans

Hirasawa, Masatomo; Takada, Kazuko

doi:10.1093/jac/dkh046

Cited by 217 publications

(146 citation statements)

References 27 publications

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“…A number of flavonoids have been shown to possess favorable antifungal activity; however, most of them including KAE barely achieve satisfactory antifungal effect in vitro when used alone. Intriguingly, they can enhance the antifungal activities of traditional agents (such as FLC) against fluconazole-resistant C. albicans and other non-Candida albicans Candida (NCAC) species, as demonstrated by several authors (Hirasawa and Takada 2004;da Silva et al 2014). There have already been enough evidences to support the involvement of efflux pump in the antifungal mechanism of action of KAE.…”

Section: Discussionmentioning

confidence: 96%

The roles of CDR1, CDR2, and MDR1 in kaempferol-induced suppression with fluconazole-resistant Candida albicans

Shao

Zhang

Wang

et al. 2015

Pharmaceutical Biology

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Context: Fungal infections caused by fluconazole-resistant Candida albicans are an intractable clinical problem, calling for new efficient antifungal drugs. Kaempferol, an active flavonoid, has been considered a potential candidate against Candida species. Objective: This work investigates the resistance reversion of kaempferol in fluconazole-resistant C. albicans and the underlying mechanism. Materials and methods: The antifungal activities of fluconazole and/or kaempferol were assessed by a series of standard procedures including broth microdilution method, checkerboard assay and time-kill (T-K) test in nine clinical strains as well as a standard reference isolate of C. albicans. Subsequently, the morphological changes, the efflux of rhodamine 6G, and the expressions of CDR 1, CDR 2, and MDR 1 were analysed by scanning electron microscope (SEM), inverted fluorescence microscope and quantitative reverse transcription polymerase chain reaction (qRT-PCR) in C. albicans z2003.Results: For all the tested C. albicans strains, the minimum inhibitory concentrations (MICs) of fluconazole and kaempferol ranged 0.25-32 and 128-256 mg/mL with a range of fractional inhibitory concentration index of 0.257-0.531. In C. albicans z2003, the expression of both CDR 1 and CDR 2 were decreased after exposure to kaempferol alone with negligible rhodamine 6G accumulation, while the expression of CDR 1, CDR 2 and MDR 1 were all decreased when fluconazole and kaempferol were used concomitantly with notable fluorescence of rhodamine 6G observed. Discussion and conclusion: Kaempferol-induced reversion in fluconazole-resistant C. albicans might be likely due to the suppression of the expression of CDR1, CDR2 and MDR1.ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 96%

The roles of CDR1, CDR2, and MDR1 in kaempferol-induced suppression with fluconazole-resistant Candida albicans

Shao

Zhang

Wang

et al. 2015

Pharmaceutical Biology

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“…It also concluded that the combined use of EGC and low dosage of amphotericin-B inhibited the growth of C. albicans, and the action was proved to be fungicidal [20].…”

Section: Mohan Et Almentioning

confidence: 97%

The Role of Green Tea in Oral Health – A Review

Mohan

Jeevanandan

2018

Asian J Pharm Clin Res

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Tea is the most widely consumed and a popular beverage in the world. Over the past decade, molecular components of teas and their health benefits on humans have received increasing attention from researchers. Functional foods are foods with positive health benefits that extend beyond their normal nutritional value. They interrupt the functions of the body and help in the management of specific health conditions and preventing pathologic changes. One such nature's gift is green tea. Green tea, a leading beverage in the Far East for the past thousand years, is an important source of polyphenol antioxidants. (EGCG) epigallocatechin 3 gallate, a polyphenol, constitute the most interesting components in green tea leaves. There is an increasing interest on the health benefits of green tea in the field of oral health. Green tea is renowned for its antioxidant, anti-cariogenic, anti inflammatory and antimicrobial properties. This traditional beverage is also used in the management of chronic systemic diseases including carcinoma. Recent studies has emphasized that in addition to the microbial activity, the host immuno-inflammatory reactions destroy the oral tissues to a greater extent. In such cases green tea is considered to be a natural preventive and curative agent. There is a growing search of evidence for understanding the beneficial role of green tea and its polyphenols in oral health. Numerous studies have shown the beneficial effects on the regular intake of green tea in maintaining oral health. Even though studies demonstrate the health effects of green tea polyphenols, more clinical and biological studies to support guidelines for green tea intake as part of prevention and treatment of specific oral pathologies are needed.

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“…Catechins from green tea have been reported to have antibacterial [12][13][14][15] , antifungal [16][17][18] , antiviral [19][20][21][22] and protein-denaturing 13,14,23,24) properties. The biological activities of these catechins are significantly influenced by such structural difference.…”

Section: Mutans or Streptococcus Sobrinus (S Sobrinus)mentioning

confidence: 99%

Antibacterial Activity and Bond Strength to Enamel of Catechin-Incorporated 4-META/MMA-TBB Resin as an Orthodontic Adhesive Resin

Saito

Hayakawa

Kuwahara

et al. 2011

J. Hard Tissue Biology.

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The purpose of this study was to assess the antibacterial efficacy of incorporating catechins into 4-META/MMA-TBB resin against Streptococcus mutans and to measure the shear bond strength of a metal bracket bonded to enamel using catechin-incorporated with 5% 4-methacryloyloxyethyl trimellitate anhydride (4-META)/methyl methacrylate (MMA)-tri-n-butyl borane (TBB) resin (catechin-resin). Catechin-resin disks were incubated with the bacterial suspension at 37 °C for 24 h. The bacterial counts (colony forming units) of the disk and the suspension were determined separately. Catechin release from catechin-resin was monitored. The catechin-containing composites were used to bond metal brackets to human premolars pretreated with self-etching primer. After the bonded samples were immersed in water at 37 °C for 24 h, shear bond strength was measured.The most significant antibacterial activity was observed in (-)-epigallocatechin gallate-resin disk and (-)-epigallocatechin gallate-resin-treated bacterial suspension when compared with the control. Catechin was released from catechin-resin during 6 week immersion in deionized water. (-)-Epicatechin gallate, (-)-epigallocatechin and (-)-epigallocatechin gallate showed a large amount of catechin release. Only significant differences was detected in bond strength between the control and (-)-epigallocatechin gallate. The addition of (-)-epigallocatechin gallate to 4-META/MMA-TBB resin confers an antibacterial effect while retaining sufficient bond strength.

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Multiple effects of green tea catechin on the antifungal activity of antimycotics against Candida albicans

Cited by 217 publications

References 27 publications

The roles of CDR1, CDR2, and MDR1 in kaempferol-induced suppression with fluconazole-resistant Candida albicans

The roles of CDR1, CDR2, and MDR1 in kaempferol-induced suppression with fluconazole-resistant Candida albicans

The Role of Green Tea in Oral Health – A Review

Antibacterial Activity and Bond Strength to Enamel of Catechin-Incorporated 4-META/MMA-TBB Resin as an Orthodontic Adhesive Resin

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