2003
DOI: 10.1038/sj.bjp.0705524
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Multiple effects of mefenamic acid on K+ currents in smooth muscle cells from pig proximal urethra

Abstract: 1 The effects of mefenamic acid on both membrane potential and K þ currents in pig urethral myocytes were investigated using patch-clamp techniques (conventional whole-cell, cell-attached, outside-out and inside-out configuration). 2 In the current-clamp mode, mefenamic acid caused a concentration-dependent hyperpolarization, which was inhibited by preapplication of 1 mM glibenclamide. In the voltage-clamp mode, mefenamic acid induced an outward current that was blocked by glibenclamide even in the presence of… Show more

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Cited by 8 publications
(8 citation statements)
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“…We employed the cell dispersion method (the gentle tapping method) previously described (Teramoto & Brading, 1996). The set‐up of the patch‐clamp experimental system used was essentially the same as described previously (Teramoto et al ., 2003). All experiments were performed at room temperature (21–23°C).…”
Section: Methodsmentioning
confidence: 99%
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“…We employed the cell dispersion method (the gentle tapping method) previously described (Teramoto & Brading, 1996). The set‐up of the patch‐clamp experimental system used was essentially the same as described previously (Teramoto et al ., 2003). All experiments were performed at room temperature (21–23°C).…”
Section: Methodsmentioning
confidence: 99%
“…Surprisingly, higher concentrations of mefenamic acid (100 mMX) were needed to cause an activation of Ca 2 þ channel activity. We have recently demonstrated the multiple actions of mefenamic acid on K þ currents in pig urethral myocytes in a similar concentration range (see Introdution, Teramoto et al, 2003). Thus, it is difficult to define that mefenamic acid is a selective activator of L-type Ca 2 þ channels due to its multiple actions.…”
Section: N Teramoto Et Almentioning
confidence: 99%
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