Multiple effects of probiotics on different types of diabetes: a systematic review and meta-analysis of randomized, placebo-controlled trials

Abstract

Background: A systematic review and meta-analysis was designed to evaluate the effect of probiotics on diabetes and its associated risk factors. Methods: We systematically searched the Cochrane Library, PubMed, EMBASE and Web of Science to June 2016. We also hand-searched the citation lists of included studies and previously identified systematic reviews to identify further relevant trials. Our primary outcome variables included glucose, glycated hemoglobin (HbA 1c ) and insulin. The pooled standardized mean difference was used to compare the effect between the probiotics and controlled groups, and the pooled standardized mean difference effect size with a 95% confidence interval (CI) was estimated using a random-effect model. Heterogeneity was assessed with Cochran's Q and Higgins I 2 tests. Two reviewers assessed trial quality and extracted data independently. The analysis and bias for each included study was performed and assessed using Review Manager 5.2. Results: Eighteen randomized, placebo-controlled studies (n = 1056 participants, 527 consuming probiotics, 529 not consuming probiotics) were included for analysis. Comparing the probiotics groups with the control groups, there were statistically significant pooled standardized

Impact of bacterial probiotics on obesity, diabetes and non-alcoholic fatty liver disease related variables: a systematic review and meta-analysis of randomised controlled trials

“…In humans, the number of studies with probiotics nearly doubled over the last 2 years. Several meta-analyses evaluated the impact of probiotics on metabolic variables11–17 but explorations to detect a disease stage severity dependence are scarce. Furthermore, no meta-analysis evaluated the contribution of bacteria used in foods that are listed as biological agents under European Food Safety Authority qualified presumption of safety list and none examined the specific contribution of bacterial species 18…”

Syringe-feeding as a novel delivery method for accurate individual dosing of probiotics in rats

“…To this end, probiotics have shown promising efficacy for a range of disorders, in particular gastrointestinal indications (Ritchie and Romanuk, 2012). Recent studies also suggested a potential clinical use in extraintestinal diseases, such as type II diabetes (Wang et al, 2017), rheumatoid arthritis (Wang et al, 2016), Alzheimer's disease (Akbari et al, 2016), and depression (Wallace and Milev, 2017). However, clinical recommendations remain premature due to a lack of high-quality evidence (Rondanelli et al, 2017).…”

Lactobacillus and Bifidobacteria Probiotic Strains Improve Glycemic and Inflammation Profiles in Obesity Model in Mice

“…Clinical data originating from several meta-analyses of randomized controlled trials (RCTs) [15][16][17][18][19][20] confirm that probiotics may have beneficial effects for diabetes, especially for T2DM patients.…”

“…The by Wang et al [20] concluded that probiotics may have beneficial effects on the reduction of glucose, insulin and HbA1c for diabetes, especially for T2DM mellitus patients.…”

“…The limitations of completed RCTs [15][16][17][18][19][20] have been notes to be as follows [19,20]: differences in the inclusion criteria and exclusion criteria for patients; different patients with previous disease and treatments were unavailable; most trials with low quality and low Jadad score; pooled date used for analysis, and unavailable individual patients' data. It was suggested that improvement a quality of clinical trials urgently needed and it would require to consider all known potential biases, update the list periodically, and score the trial by multiplying (not adding) the component scores with regard to risks of potential bias to obtain an overall score, etc.…”