2018
DOI: 10.5603/ait.a2018.0024
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Multiple electrode aggregometry as a method for platelet function assessment according to the European guidelines

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Cited by 8 publications
(7 citation statements)
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“…However, in general, MEA and whole blood aggregometry correlate only moderately well with LTA, and there is debate over MEA's ability to predict clinical outcomes. As such, LTA continues to be considered the criterion standard in platelet aggregation function testing (2,45,50,51).…”
Section: Multiple Electrode Aggregometry and Multiplate Analyzermentioning
confidence: 99%
“…However, in general, MEA and whole blood aggregometry correlate only moderately well with LTA, and there is debate over MEA's ability to predict clinical outcomes. As such, LTA continues to be considered the criterion standard in platelet aggregation function testing (2,45,50,51).…”
Section: Multiple Electrode Aggregometry and Multiplate Analyzermentioning
confidence: 99%
“…In order to perform MEA, an agonist of a particular pathway of activation is added to whole blood samples with anticoagulantcitrate or hirudin. What is important, MEA can be used in the assessment of platelet functions of patients on various antiplatelet drugs-ASA, P2Y 12 inhibitors, or GPIIb/IIIa receptor blockers (Pluta et al, 2018).…”
Section: Determination Of Platelet Function On Antiplatelet Therapymentioning
confidence: 99%
“…It evaluates the platelet function of several pathways of platelet adhesion and aggregation, and it is dependent on cyclooxygenase (ASPItest, Aspirin®; arachidonic acid), collagen (COLtest), adenosine diphosphate (ADPtest), thrombin (TRAPtest, thrombin receptor activating peptide), and von Willebrand factor (RISTOtest, ristocetin). 17,18 The Multiplate RISTOtest because of its POC availability and specificity for vWF, could be used to diagnose vWF deficiency in patients with bleeding complications during ECMO support. 19,20 However, the gold standards for diagnosing vWF deficiency are special hematological tests such as the quantification of vWF antigen (vWF : Ag), vWF ristocetin cofactor activity assay (vWF : RCo), 21,22 and vWF collagen-binding capacity assay (vWF : CB).…”
Section: Introductionmentioning
confidence: 99%
“…Multiplate analyzers enable the testing of primary hemostasis (platelet clot formation in “low shear stress” conditions that are dependent on platelet adhesion and aggregation). It evaluates the platelet function of several pathways of platelet adhesion and aggregation, and it is dependent on cyclooxygenase (ASPItest, Aspirin®; arachidonic acid), collagen (COLtest), adenosine diphosphate (ADPtest), thrombin (TRAPtest, thrombin receptor activating peptide), and von Willebrand factor (RISTOtest, ristocetin) 17,18 . The Multiplate RISTOtest because of its POC availability and specificity for vWF, could be used to diagnose vWF deficiency in patients with bleeding complications during ECMO support 19,20 .…”
Section: Introductionmentioning
confidence: 99%