Multiple etiologies of equine recurrent uveitis – A natural model for human autoimmune uveitis: A brief review

Witkowski, Lucjan; Cywińska, Anna; Paschalis-Trela, Katarzyna; Crisman, Mark V.; Kita, Junji

doi:10.1016/j.cimid.2015.11.004

Cited by 34 publications

(33 citation statements)

References 55 publications

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“…Our results suggest detection of Leptospira DNA is more likely in vitreous samples than in aqueous humour, but further studies with a larger number of positive samples are needed to confirm this. The spirochete is thought to induce ERU through direct ocular infection, as well as acting indirectly by inducing an immune‐mediated disease through molecular mimicry, bystander activation and epitope spreading . We speculate that, regardless which segment of the eye is initially penetrated and where the DNA is detected, the disease can develop in both segments.…”

Section: Discussionmentioning

confidence: 93%

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Detection of intraocular Leptospira spp. by real‐time polymerase chain reaction in horses with recurrent uveitis in Belgium

Sauvage

Monclin

Elansary

et al. 2018

Equine Veterinary Journal

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Section: Discussionmentioning

confidence: 93%

“…Its exact pathogenesis remains not fully understood. It is considered to be immune-mediated and is influenced by the cause of its first bout of inflammation, environmental factors and genetic characteristics of the affected horse [2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Detection of intraocular Leptospira spp. by real‐time polymerase chain reaction in horses with recurrent uveitis in Belgium

Sauvage

Monclin

Elansary

et al. 2018

Equine Veterinary Journal

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“…infections may show acute or chronic manifestations; however, most cases present with non-specific symptoms, which makes the disease difficult to diagnose. Recurrent uveitis, abortion, and other reproductive disorders have been reported by several authors (ELLIS, 2015;LINHARES et al, 2005;WITKOWSKI et al, 2016).…”

Section: Introductionmentioning

confidence: 87%

Seroepidemiology of leptospirosis and toxoplasmosis in equines in the northwest region of Paraná

Pacheco

Bondezan

Pereira

et al. 2019

SCA

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Leptospirosis and toxoplasmosis are diseases that may affect man and domestic and wild animals. They also have wide geographical distributions and thus cause large public health issues. The objective of the current study was to conduct leptospirosis and toxoplasmosis seroepidemiology in horses used for animal traction in small rural propertiesof the municipality of Umuarama, in northwest region of the state of Paraná, Brazil. Blood samples were collected from 312 horses from 87 small farms. Microscopic agglutination tests (MAT) and indirect immunofluorescence (IIF) analysis were performed on sera to detect leptospirosis and toxoplasmosis, respectively. These were performed in conjunction with an epidemiological questionnaire. The MAT results included 180 (57.69%) samples that were considered reactive with titers between 100 and 12800 for one or more serovars. Thirty-three (10.57%) samples subjected to IIF were considered reactive, with titers ranging between 64 and 1024. From the analyzed variables, contact with wild animals (p= 0.012) and animal exchange between properties (p = 0.004) were associated with toxoplasma infection. The study revealed that horses in the northwestern region of Paraná were exposed to Leptospira spp. and Toxoplasma gondii, with an insignificant implication of the animals' clinical condition; however, since it is possible for animals to transmit infection to other animals as well as humans via the intermittent shedding of leptospires through urine into the environment, it may be considered a problem of one health. As for the presence of T. gondii antibodies, these horses played the role of sentinel of the infection. Environmental sanitation measures, serological studies of herds, control of rodents and felids on properties, and the dissemination of information about these diseases are relevant for disease control at the study site.A leptospirose e a toxoplasmose são enfermidades de ampla distribuição geográfica e podem acometer o homem, animais domésticos e selvagens que causam elevados problemas para a saúde pública. O objetivo deste trabalho foi realizar a soroepidemiologia da leptospirose e toxoplasmose em equinos utilizados como tração animal de pequenas propriedades rurais do município de Umuarama, região noroeste do estado do Paraná, Brasil. Foram coletadas amostras de sangue de 312 equinos de 87 pequenas propriedades rurais. Para detectar a leptospirose e toxoplasmose os soros foram submetidos às técnicas de soroaglutinação microscópica (SAM) e imunofluorescencia indireta (IFI) respectivamente associada ao preenchimento de um questionário epidemiológico. Na SAM, 180 (57,69%) amostras foram consideradas reagentes apresentando títulos entre 100 e 12800, para um ou mais sorovares. Na IFI, 33 (10,57%) amostras foram consideradas reagentes com títulos de 64 a 1024. Em relação às variáveis analisadas, o contato com animais selvagens (p= 0,012) e troca de animais entre propriedades (p= 0,004) foram associados à infecção toxoplásmica. O estudo revela que os equinos da região noroeste do Pa...

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“…El estudio de las alteraciones oftalmológicas de los equinos se ha centrado en alteraciones particulares como la uveítis recurrente equina, las neoplasias oculares y las ulceras corneales (BROOKS, 2012;BROOKS, 2014a;CARVALHO et al 2014;MONTGOMERY, 2014;WITKOWSKI et al 2016) y los estudios de prevalencia se han realizado principalmente mediante el análisis de la casuística clínica de hospitales (HURN & TRUNER, 2006;THANGADURAI et al 2010;TAMILMAHAN et al 2013).…”

Section: Introductionunclassified

Úlcera corneal en un caballo de silla argentino de Córdoba, Colombia

Montes

2018

Rev Colombiana Cienc Anim. RECIA

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We report a case of an Argentine castrated male horse, about 8 years of age, which was attended by the outpatient clinic of the Medical-Surgical Clinic of Large Animals of the Faculty of Veterinary Medicine and Zootechnics of the University of Cordoba. The anamnesis indicates that the horse was in field work in a wooded land, which presented the next day of work increase in the production of tears and edema in the eyelids of the right eye, which was treated with eye drops antibiotic for 3 days. Fifteen days after the treatment was applied, the horse managers did not notice improvement, so they requested Veterinary Medical help. In the clinical evaluation of the animal, epifhora with purulent secretion, chemosis, conjunctivitis and edema with marked lesion of the corneal epithelium were found in the right eye. Special tests such as the Schrimer test were performed, with marked increase in lacrimal secretion; Subsequently the Fluorescein Sodium test was performed, evidencing the marked ulceration of the cornea. In definitive diagnosis, based on the special ophthalmic examination and the tests performed was of corneal ulcer.

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Multiple etiologies of equine recurrent uveitis – A natural model for human autoimmune uveitis: A brief review

Cited by 34 publications

References 55 publications

Detection of intraocular Leptospira spp. by real‐time polymerase chain reaction in horses with recurrent uveitis in Belgium

Detection of intraocular Leptospira spp. by real‐time polymerase chain reaction in horses with recurrent uveitis in Belgium

Seroepidemiology of leptospirosis and toxoplasmosis in equines in the northwest region of Paraná

Úlcera corneal en un caballo de silla argentino de Córdoba, Colombia

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