Multiple Factors Are Involved in the Dysarthria Associated With Parkinson's Disease: A Review With Implications for Clinical Practice and Research

Sapir, Shimon

doi:10.1044/2014_jslhr-s-13-0039

Cited by 144 publications

(87 citation statements)

References 155 publications

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“…When considered as a premotor region, increased left GPi–left PMd/LMC connectivity in PDSI subjects could be related to a greater reliance on external cues to compensate for internal cueing deficits during speech production. Problems with internal cueing have been well documented in PD (Jahanshahi et al., 1995; Siegert, Harper, Cameron, & Abernethy, 2002) and are thought to play a role in PD dysarthria (Sapir, 2014). Compared to habitual (internally cued) speech, measures of speech function and intelligibility improve when PD subjects are prompted (externally cued) to speak more loudly, clearly, or slowly (Dromey & Ramig, 1998; Ho, Bradshaw, Iansek, & Alfredson, 1999; Sapir, 2014; Tjaden, Sussman, & Wilding, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Problems with internal cueing have been well documented in PD (Jahanshahi et al., 1995; Siegert, Harper, Cameron, & Abernethy, 2002) and are thought to play a role in PD dysarthria (Sapir, 2014). Compared to habitual (internally cued) speech, measures of speech function and intelligibility improve when PD subjects are prompted (externally cued) to speak more loudly, clearly, or slowly (Dromey & Ramig, 1998; Ho, Bradshaw, Iansek, & Alfredson, 1999; Sapir, 2014; Tjaden, Sussman, & Wilding, 2014). As motor preparatory activity in PMd is biased toward the planning and execution of movements that are externally cued (Halsband, Matsuzaka, & Tanji, 1994; Halsband & Passingham, 1982; Lu, Arai, Tsai, & Ziemann, 2012; Mushiake, Inase, & Tanji, 1991), increased connectivity with GPi could reflect a mechanism for compensatory reliance on external cues during speech production in PD.…”

Section: Discussionmentioning

confidence: 99%

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Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

et al. 2018

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IntroductionSpeech impairment in Parkinson's disease (PD) is pervasive, with life‐impacting consequences. Yet, little is known about how functional connections between the basal ganglia and cortex relate to PD speech impairment (PDSI). Whole‐brain resting‐state connectivity analyses of basal ganglia nuclei can expand the understanding of PDSI pathophysiology.MethodsResting‐state data from 89 right‐handed subjects were downloaded from the Parkinson's Progression Markers Initiative database. Subjects included 12 older healthy controls (“OHC”), 42 PD patients without speech impairment (“PDN”), and 35 PD subjects with speech impairment (“PDSI”). Subjects were assigned to PDN and PDSI groups based on the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) Part III speech item scores (“0” vs. “1–4”). Whole‐brain functional connectivity was calculated for four basal ganglia seeds in each hemisphere: putamen, caudate, external globus pallidus (GPe), and internal globus pallidus (GPi). For each seed region, group‐averaged connectivity maps were compared among OHC, PDN, and PDSI groups using a multivariate ANCOVA controlling for the effects of age and sex. Subsequent planned pairwise t‐tests were performed to determine differences between the three groups using a voxel‐wise threshold of p < 0.001 and cluster‐extent threshold of 272 mm3 (FWE<0.05).ResultsIn comparison with OHCs, both PDN and PDSI groups demonstrated significant differences in cortical connectivity with bilateral putamen, bilateral GPe, and right caudate. Compared to the PDN group, the PDSI subjects demonstrated significant differences in cortical connectivity with left putamen and left GPi. PDSI subjects had lower connectivity between the left putamen and left superior temporal gyrus compared to PDN. In addition, PDSI subjects had greater connectivity between left GPi and three cortical regions: left dorsal premotor/laryngeal motor cortex, left angular gyrus, and right angular gyrus.ConclusionsThe present findings suggest that speech impairment in PD is associated with altered cortical connectivity with left putamen and left GPi.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

et al. 2018

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“…In the case of PD, patients have reduced vocal quality (e.g., breathiness or roughness), intensity (loudness), inflection, and articulation [19, 39, 40], even in the early stages of disease progression [1]. Changes in vocalizations in animal models of PD have been demonstrated in several model species.…”

Section: Discussionmentioning

confidence: 99%

Vocalization development in common marmosets for neurodegenerative translational modeling

Jones

Duffy

Hoffman

et al. 2018

Neurological Research

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Objectives In order to facilitate the study of vocalizations in emerging genetic common marmoset models of neurodegenerative disorders, we aimed to analyze call type changes across age in a translational research environment. We hypothesized that acoustic parameters of vocalizations would change with age, reflecting growth of the vocal apparatus and a maturation of control needed to make adult-like calls. Methods Nineteen developing common marmosets were longitudinally video- and audio-recorded between the ages of 1–149 days in a naturalistic setting without any vocalization elicitation protocol. Vocalizations were coded for call type (cry, tsik, trill, phee, and trill-phee) and analyzed for duration (sec), minimum & maximum frequency (Hz), and bandwidth (Hz). Mixed model linear regressions were performed to assess the effects of age on call parameters listed above for each call type. Results Cries decreased in duration (p=0.038), maximum frequency (p=0.047), and bandwidth (p=0.023) with age. Tsik calls decreased in duration (p=0.002) and increased in minimum frequency (p=0.004) and maximum frequency (p=0.005) with age. Trill calls increased in duration (p=0.003), and trillphee bandwidth (p=0.031) decreased with age. Discussion Our results demonstrate that development of common marmoset vocalizations is call type-dependent and that changes in acoustic parameters can be detected without complex vocalization elicitation paradigms or specialized audio recording equipment. Thus, we demonstrate the feasibility of a naturalistic protocol to collect and objectively analyze marmoset vocalizations longitudinally. This approach may be useful for studying vocal communication deficits in genetic models of neurodegenerative disorders.

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“…The disease is associated with significant voice and speech deficits (Goberman & Blomgren, 2008; Harel, Cannizzaro, & Snyder, 2004; Holmes, Oates, Phyland, & Hughes, 2000; Narayana et al, 2009; Stewart et al, 1995) that occur in approximately 90% of affected individuals (Ho, Iansek, Marigliani, Bradshaw, & Gates, 1998). Voice and speech deficits, termed hypokinetic dysarthria, often include a quiet, hoarse, monotonous voice, imprecise articulation and compromised intelligibility (Kim, Kent, & Weismer, 2011; Logemann, Fisher, Boshes, & Blonsky, 1978; Sapir, 2014). These vocal deficits can lead to impaired interpersonal communication that significantly impacts quality of life in PD patients (Duffy, 2006; Fox et al, 2006; Karlsen, Tandberg, Arsland, & Larsen, 2000).…”

Section: Introductionmentioning

confidence: 99%

Decreased approach behavior and nucleus accumbens immediate early gene expression in response to Parkinsonian ultrasonic vocalizations in rats

Pultorak

Kelm‐Nelson

Holt

et al. 2015

Social Neuroscience

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Many individuals with Parkinson disease (PD) have difficulty producing normal speech and voice, resulting in problems with interpersonal communication and reduced quality of life. Translational animal models of communicative dysfunction have been developed to assess disease pathology. However, it is unknown whether acoustic feature changes associated with vocal production deficits in these animal models lead to compromised communication. In rodents, male ultrasonic vocalizations (USVs) have a well-established role in functional inter-sexual communication. To test whether acoustic deficits in USVs observed in a PINK1 knockout (KO) PD rat model compromise communication, we presented recordings of male PINK1 KO USVs and normal wild-type (WT) USVs to female rat listeners. We measured approached behavior and immediate early gene expression (c-Fos) in brain regions implicated in auditory processing and sexual motivation. Our results suggest that females show reduced approach in response to PINK1 KO USVs compared to WT. Moreover, females exposed to PINK1 KO USVs had lower c-Fos immunolabeling in the nucleus accumbens, a region implicated in sexual motivation. These results are the first to demonstrate that vocalization deficits in a rat PD model result in compromised communication. Thus, the PINK1 KO PD model may be valuable for assessing treatments aimed at restoring vocal communicative function.

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Multiple Factors Are Involved in the Dysarthria Associated With Parkinson's Disease: A Review With Implications for Clinical Practice and Research

Abstract: These findings have important implications for clinical practice and research.

Cited by 144 publications

References 155 publications

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

Altered resting‐state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson's disease

Vocalization development in common marmosets for neurodegenerative translational modeling

Decreased approach behavior and nucleus accumbens immediate early gene expression in response to Parkinsonian ultrasonic vocalizations in rats

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