Multiple fixed drug eruption caused by acetaminophen

Hayashi, Hideyuki; Shimizu, Tatsuo; Shimizu, Hiroshi

doi:10.1046/j.1365-2230.2003.01285_9.x

Cited by 14 publications

(8 citation statements)

References 8 publications

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“…In studies performed before 2000, the most common causative agent of FDE was trimethoprim-sulfamethoxazole 14,15,16. In the past, FDEs caused by NSAIDs and acetaminophen were known to be rare,18 but in reports after 2000, NSAIDs (16%-35%) were the second most common factor after antibiotics (39%-65%), and followed by anticonvulsant drugs (16%-30%) 19,20,21. In Korea, FDE caused by NSAIDs was first reported in 1996,22 and other cases have since been reported 23,24.…”

Section: Discussionmentioning

confidence: 99%

“…The challenge test can be performed at varying doses, and usually starts with a very low dose that is increased gradually to a therapeutic dosage 4. A lymphocyte transformation test is a laboratory test approved for delayed drug hypersensitivities such as maculopapular eruption, drug hypersensitivity syndrome and SJS,34 but its usefulness in testing for FDE is still under investigation, even though some studies have reported positive results 18,35. These diagnostic tests are clinically important, not only for diagnosis, but also for identification of the causative drug(s).…”

Section: Discussionmentioning

confidence: 99%

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Clinical Features of Fixed Drug Eruption at a Tertiary Hospital in Korea

Jung

Cho

Kim

et al. 2014

Allergy Asthma Immunol Res

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PurposeFixed drug eruption (FDE) is characterized by a well-defined erythematous patch, plaque, or bullous eruption that recurs at the same site as the result of systemic exposure to a causative drug, and resolves with or without hyperpigmentation. This study was carried out to identify the common causative drugs and clinical features of FDE in Korea.MethodsWe reviewed electronic medical records of all patients diagnosed with FDE from January 2000 to December 2010 at a tertiary hospital in Korea.ResultsA total of 134 cases were diagnosed as FDE. The mean age was 35.9 years (range, 0-82 years) and 69 (51.5%) of the patients were male. The mean duration from the first event to attending hospital was 1.9 years (range, 1-20 years). The mean number of recurrences was 2.6 (1-10), and 72.6% of patients sought medical care after experiencing symptoms twice or more. Four patients (3.1%) needed hospitalization. The most common sites were the upper extremities (47.7%), followed by the lower extremities, face, abdomen, chest, buttocks and perineum. Clear documentation on the causative drugs was available for 38 patients (28.4%), and among these, non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen accounted for 71.1% of cases, and antibiotics accounted for 15.8%. Eighty patients (59.7%) underwent active treatment for FDE, and topical steroids were most frequently prescribed (43.3%), with systemic steroids used in 11.2% of patients.ConclusionsNSAIDs and acetaminophen were the main causative agents of FDE, however, the causative agents were not assessed in 25% of patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical Features of Fixed Drug Eruption at a Tertiary Hospital in Korea

Jung

Cho

Kim

et al. 2014

Allergy Asthma Immunol Res

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“…Despite its widespread use, adverse reactions are unusual. FDE to paracetamol is well‐reported, but rare 1–4 . It is known that FDE can affect the genital area only; however, the majority of case reports are in men.…”

Section: Introductionmentioning

confidence: 99%

Vulval fixed drug eruption due to paracetamol

Drummond

Fischer

2009

Aust J Dermatology

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Paracetamol is a readily available non-prescription analgesic. Fixed drug eruption (FDE) is a wellreported side effect of paracetamol, usually the classic, pigmenting type. In women, it may present as a chronic, erosive vulvitis. We describe a case of FDE due to paracetamol presenting as a chronic erosive vulvitis in an older woman taking multiple medications. Diagnosis was delayed because paracetamol is available without prescription, taken intermittently and may be omitted from the clinical history. Cessation of paracetamol led to prompt resolution of symptoms. Consideration should be given to paracetamol as a cause of FDE presenting as a chronic erosive vulvitis.

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“…Les toxidermies les plus fréquemment liées au paracétamol sont le rash maculo-papuleux, l'urticaire, la pustulo-exanthématose aiguë généralisée, l'érythème pigmenté fixe, le purpura et le rash retardé [8][9][10][11][12]. D'autres réactions plus graves peuvent se voir : le choc anaphylactique, le bronchospasme et l'oedème de Quincke [13,14].…”

Section: Discussionunclassified