Multiple Gastrointestinal Immune-Related Adverse Events From Immune Checkpoint Inhibitor Therapy

Abstract

OBJECTIVES: Describe immune related adverse events (irAE) affecting multiple organs of the gastrointestinal system in patients who received immune checkpoint inhibitors (ICI). METHODS: Within a 2843-patient retrospective cohort consisting of patients with cancer treated with ICIs, EMERSE (Electronic Medical Record Search Engine), an information retrieval system, was used to search free text in the medical record to identify patients with multiple gastrointestinal irAEs. RESULTS: 13 patients developed multiple gastrointestinal irAEs (0.46%). The most common patterns of multisystem gastrointestinal irAE were colitis + pancreatitis and colitis + enteritis. CONCLUSIONS: Multisystem gastrointestinal irAEs are rare but warrant further characterization and attention.