Multiple glomus tumours

Balatsouras, Dimitrios G.; Eliopoulos, P.; Economou, Constantinos

doi:10.1017/s0022215100120080

Cited by 41 publications

(28 citation statements)

References 68 publications

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“…[21][22][23] In our cases, we found a family history of CBT in 1%, whereas in the U.S., it has been reported to be from 7% to 10%, and in Italy, 25%. 2,4,24,25 In patients with a family history, the presence of multiple tumors has been reported as high as 42%.…”

Section: Discussioncontrasting

confidence: 43%

Carotid body tumors in inhabitants of altitudes higher than 2000 meters above sea level

López-Garza²,

1998

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Section: Discussioncontrasting

confidence: 43%

Carotid body tumors in inhabitants of altitudes higher than 2000 meters above sea level

López-Garza²,

1998

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“…There are several aspects of such tumours that are of special clinical importance. As paragangliomas of the head and neck region are rare tumours, individual experience is usually limited [16]. Owing to the vascular nature of these tumours, preoperative biopsy is usually not possible without considerable risk of bleeding [9].…”

Section: Introductionmentioning

confidence: 99%

Clinical value of somatostatin receptor imaging in patients with suspected head and neck paragangliomas

Schmidt

Fischer

Dietlein

et al. 2002

European Journal of Nuclear Medicine and Molecular Imaging

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Paragangliomas or glomus tumours of the head and neck region are rare somatostatin receptor-expressing neuroendocrine tumours. Precise preoperative diagnosis is of special importance in order to adequately weigh the potential benefit of the operation against the inherent risks of the procedure. In this study, the clinical value of somatostatin receptor imaging was assessed in 19 patients who underwent somatostatin receptor scintigraphy because of known or suspected paraganglioma of the head and neck region. The results were compared with the results of computed tomography and/or magnetic resonance imaging, histology and clinical follow-up. [(111)In-DTPA- D-Phe(1)]-octreotide scintigraphy was performed 4-6 and 24 h after i.v. injection of 140-220 MBq (111)In-octreotide. Whole-body and planar images as well as single-photon emission tomography images were acquired and lesions were graded according to qualitative tracer uptake. Somatostatin receptor imaging was positive in nine patients, identifying paragangliomas for the first time in three patients and recurrent disease in six patients. In one patient, a second, previously unknown paraganglioma site was identified. Negative results were obtained in ten patients. These patients included one suffering from chronic hyperplastic otitis externa, one with granuloma tissue and an organised haematoma, one with an acoustic neuroma, one with an asymmetric internal carotid artery, two with ectasia of the bulbus venae jugularis and one with a jugular vein thrombosis. In two patients with a strong family history of paraganglioma, individual involvement could be excluded. In only one patient did somatostatin receptor imaging and magnetic resonance imaging yield false negative results in respect of recurrent paraganglioma tissue. It is concluded that somatostatin receptor scintigraphy provides important information in patients with suspected paragangliomas of the head and neck region and has a strong impact on further therapeutic management.

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“…9,10,13 In cases of bilateral tumours, serum catecholamine levels as well as urinary vanilmandelic acid and metanephrine levels should be assessed. 12,14 Magnetic resonance imaging and contrast enhanced computed tomography scans are additional noninvasive diagnostic tools. With magnetic resonance imaging, paragangliomas smaller than 0.8 cm in diameter can be detected 9,12 .…”

Section: Discussionmentioning

confidence: 99%

“…Patients with a family history and hypertensive palpitation attacks with flushing should be assessed. 12,14 Surgery is the first choice of treatment. Radiotherapy has been used as the sole treatment in a few cases, and the short-term results are disputable 15 .…”

Section: Discussionmentioning

confidence: 99%