Multiple Granular Cell Tumors

Rifkin, R.; Blocker, Sterling H.; Palmer, James O.; Ternberg, Jessie L.

doi:10.1001/archsurg.1986.01400080091017

Cited by 38 publications

(6 citation statements)

References 6 publications

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“…These tumours have a higher incidence amongst women and a greater prevalence amongst people of African descent. There has been one case report of a mother and son, both of whom presented in childhood with multiple granular cell tumours [4]. While the origins of granular cell tumours are often debated, Abrikossoff originally postulated a myogenic origin and termed this a “myoblastoma.” These tumours are now considered to be neoplasms of neural origin, as evidenced by immunohistochemical studies [5].…”

Section: Introductionmentioning

confidence: 99%

An Unusual Granular Cell Tumour of the Buttock and a Review of Granular Cell Tumours

Paul

Osipov

2013

Case Reports in Dermatological Medicine

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Granular cell tumours, first described by Abrikossoff in 1926, are known to occur in skin, connective tissue, breast, gastrointestinal and genital tracts. While they are rare, they are more common in people of African descent and show a slight female preponderance, usually presenting as solitary and painless masses. Less than 10% of occurrences are multiple, and fewer than 3% of tumours behave in a malignant fashion. The mean age, at presentation, is 40–60 years. We report a case of granular cell tumour in a young white male presenting with a painful soft tissue tumour in his buttock. The presentation is unusual because of the age, patient demographic, body site, and clinical presentation. The clinical and histological aspects are reviewed in the context of this clinical case and the associated literature.

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Section: Introductionmentioning

confidence: 99%

An Unusual Granular Cell Tumour of the Buttock and a Review of Granular Cell Tumours

Paul

Osipov

2013

Case Reports in Dermatological Medicine

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“…A literature review of the reported cases and studies of multiple GCTs affecting patients younger than 18 years was performed, and the findings are summarized in Table 2. 1,23–60…”

Section: Discussionmentioning

confidence: 99%

Multifocal Cutaneous Granular Cell Tumor in Children: A Rare Entity

El‐Khalawany

Rageh

Hassab-El-Naby

2021

The American Journal of Dermatopathology

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Granular cell tumors (GCTs) are rare soft tissue tumors of Schwann cell origin that manifest as papulonodular lesions and occur mainly in adults. The diagnosis is usually confirmed by histopathology. Most of GCTs are benign, but some lesions may exhibit malignant criteria. This study is a retrospective case series including all children with histopathologically documented multiple GCTs who attended the dermatology department of the university hospitals between February 2008 and March 2021. The objective of our study was to raise awareness to this unrecognized and rare entity in such age group. The study included 9 patients (6 girls and 3 boys) with multiple GCTs. Their age ranged between 5 and 13 years. The lesions were skin-colored to light brown, firm, smooth-surfaced nodules. Most of the lesions were on the extremities, and their mean diameter was 160.5 mm 2 . None of the lesions exhibited any malignant criteria on histopathology. No extracutaneous or mucosal lesions were detected. Dermatologists should be aware of this rare condition in children because early recognition allows more conservative resection of the tumor and less invasive reconstruction of the defect. Our study highlights that multifocality does not necessarily indicate malignancy or other systemic comorbidities.

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“…Multiplicity should not be taken as evidence for malignancy [ 13 ]. Familial occurrence has been reported, but there is no clear evidence for a syndrome [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Metachronous Occurrence of Granular Cell Tumor in Breast Skin and Scalp: Diagnostic Challenging Differentiating Benign from Malignant and a Literature Review

Akkaya

Toru

Ayva

et al. 2016

Case Reports in Pathology

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Granular cell tumor (GCT) is a Schwann cell related benign neoplasm of soft tissue. GCT is an uncommon entity that occurs in a wide variety of body sites, but it is generally presented in the skin, oral cavity, superficial soft tissue, and respiratory and digestive tracts. Most of the GCTs are benign but clinically and radiologically these may mimic malignancy. Histopathological diagnosis is gold standard for establishing the true nature of the lesion. GCT is most commonly solitary but in about 10% of cases can be multifocal, usually involving various skin and soft tissue sites versus involving various internal sites. Therefore, these can involve skin and soft tissue or submucosa and viscera. GCT is usually benign; however, local recurrence is common due to incomplete removal. Malignant cases are rarely reported in 1-2% of cases. In this study, we report clinical and histopathological findings of a 36-year-old woman with metachronous GCT in breast and scalp. The clinical features raise the question of whether these are metachronous benign GCTs or whether this is establishment of malignant behavior. The aim of this report is to present the histopathological and clinical features of GCT and the diagnostic challenge of differentiating benign from malignant GCT.

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Multiple Granular Cell Tumors

Cited by 38 publications

References 6 publications

An Unusual Granular Cell Tumour of the Buttock and a Review of Granular Cell Tumours

An Unusual Granular Cell Tumour of the Buttock and a Review of Granular Cell Tumours

Multifocal Cutaneous Granular Cell Tumor in Children: A Rare Entity

Metachronous Occurrence of Granular Cell Tumor in Breast Skin and Scalp: Diagnostic Challenging Differentiating Benign from Malignant and a Literature Review

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