Multiple Hamartoma Syndrome (Cowden's Disease)

Nuss, Donald D.

doi:10.1001/archderm.1978.01640170043008

Cited by 76 publications

(27 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Various tumours have been documented in the skin and mueous membranes in Cowden's disease [2][3][4][5][6][7]. In some individuals, fibromas and palmoplantar keratoses are seen at birth; in most cases.…”

Section: Discussionmentioning

confidence: 99%

Cowden's disease (multiple hamartoma syndrome) An underdiagnosed syndrome with increased risk of malignant development

Asklöf

Johansson

Svensson

1995

Acad Dermatol Venereol

View full text Add to dashboard Cite

Cowden's disease is so often followed by malignant diseases, such as cancer of the breast and thyroid, and different forms of gynaecological cancer, that surgeons should be made especially aware of those changes in skin and mucous membranes which, if multiple are pathognomic. It remains, however, an underdiagnosed syndrome. We believe a number of other conditions are also associated with Cowden's disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Cowden's disease (multiple hamartoma syndrome) An underdiagnosed syndrome with increased risk of malignant development

Asklöf

Johansson

Svensson

1995

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…The tumor suppressing function of PTEN in SCC has been shown in patients with Cowden’s disease, in vitro in human keratinocytes, and in vivo , using a chemical skin carcinogenesis model. The association of cutaneous SCC with Cowden’s disease has also been reported (Nuss et al , 1978; Camisa et al , 1984). The decreasing levels of PTEN expression are correlated with a malignant transformation of the skin induced by UVA (315–400 nm), as shown by the formation of SCC in nude mice (He et al , 2006).…”

Section: Pten In Skin Cancermentioning

confidence: 91%

PTEN: New Insights into Its Regulation and Function in Skin Cancer

Ming

2009

Journal of Investigative Dermatology

View full text Add to dashboard Cite

Skin cancer is the most common cancer in the United States. UV radiation in sunlight is the major environmental factor causing skin cancer development. PTEN (phosphatase and tensin homolog deleted on chromosome 10), a recently discovered tumor suppressor gene, is frequently mutated, deleted, or epigenetically silenced in various human cancers. PTEN negatively regulates the oncogenic phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathways. PTEN is clearly a critical tumor suppressor for skin cancer in humans and in mice. This review summarizes the recent progress in the function of PTEN in the development of skin cancer, including basal-cell carcinoma, squamous-cell carcinoma, and melanoma. The regulation of PTEN by UV radiation is also discussed in association with skin carcinogenesis. Understanding the fundamental mechanisms that lead to the reduction of PTEN function in skin carcinogenesis and the essential association with UV radiation opens up new opportunities for molecular chemoprevention and therapy of skin cancer by targeting PTEN pathways.

show abstract

“…Die Prävalenz der Brustkarzinome liegt bei 25% [21,23]. Die Skelettanomalien zeigten sich in einem adenoiden Gesicht (adenoid facies), in Makrozephalie, Trichterbrust (pectus excavatum) und in einer Skoliose (scoliosis) sowie in überzähligen Fingern (supernumerary digits) [1, 6,16,17,[21][22][23]. [5,25].…”

Section: Schlüsselwörterunclassified

Cowden-Syndrom (Multiple-Hamartome-Syndrom)

Kandemir

Öztürk

Kandilogˇlu

1999

Mund Kiefer GesichtsChir

View full text Add to dashboard Cite

First lesions of Cowden syndrome appear in the oral cavity and on the skin. Malignant transformation is a late, common event in thyroid and breast. The early diagnosis of Cowden disease prior to the development of internal malignancy, particularly of the breast and the thyroid gland, is very important. We emphasize that the dentist may be the first health care professional who recognizes the syndrome, and this is a crucial step in the prevention and cure of the predictable malignancy. This article presents a typical case of Cowden disease.

show abstract

Multiple Hamartoma Syndrome (Cowden's Disease)

Cited by 76 publications

References 3 publications

Cowden's disease (multiple hamartoma syndrome) An underdiagnosed syndrome with increased risk of malignant development

Cowden's disease (multiple hamartoma syndrome) An underdiagnosed syndrome with increased risk of malignant development

PTEN: New Insights into Its Regulation and Function in Skin Cancer

Cowden-Syndrom (Multiple-Hamartome-Syndrom)

Contact Info

Product

Resources

About