Multiple hereditary osteochondromatosis with spinal cord compression: case report

Mireles-Cano, José Nicolás; Sánchez-Zavala, Natalia; Chagolla-Santillán, Miguel Ángel; Orozco-Ramirez, Segio M; Silva-Cerecedo, Pedro; Murguía-Pérez, Mario; Rueda-Franco, Fernando

doi:10.1007/s00381-017-3645-1

Cited by 3 publications

(6 citation statements)

References 19 publications

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“…Intracanal lesions are of great concern as they can compress the spinal cord. The reported incidence of these tumours range between 4 and 27% of cases [30] and are mostly located in the cervical region [5].This study reports 22 lesions throughout all levels of the vertebral column, they are located on the vertebral bodies, the spinous processes and the transverse processes with no obvious cases of intracanal lesions on imaging. Whether the high number of lesions indicate a more robust study that is more representative of the disease or whether this is an extreme case of HME remains to be seen and will only be answered with similar full body investigations.…”

Section: Discussionmentioning

confidence: 63%

“…Cases of HME with vertebral lesions have commonly been reported between 1 and 9% [5,27], however more recently some reports have reported incidences of 23% [27], 38% [28] and 68% [2,27]. Whilst some of these studies may be overestimating due to selection bias it is clear that examining all HME cases for vertebral lesions, and not just symptomatic cases, leads to higher reporting of incidence rates.…”

Section: Discussionmentioning

confidence: 99%

“…Jackson et al [28] reported that the average lesions in a single patient was 2.25 with the range being between 1 and 4, in addition it has been stated that finding lesions in multiple levels of the vertebral column is rare [29]. The osteochondromas that do grow on the vertebrae can occur in multiple areas reflecting the many ossifications centres; they are found on the vertebral bodies, tips of the spinous processes, the transverse processes and the articular processes [5]. Intracanal lesions are of great concern as they can compress the spinal cord.…”

Section: Discussionmentioning

confidence: 99%

“…Osteochondromas account for 20-50% of all benign bone tumours [3] equating to 10% of all bone growths [4]. They commonly appear a singular entity with only 10% of patients suffering from the multiple form seen in HME [1,5]. The disease has a prevalence of between 1: 50,000 and 1:100,000 [3].…”

Section: Introductionmentioning

confidence: 99%

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An unusual example of hereditary multiple exostoses: a case report and review of the literature

Chilvers

Gallagher

Jeffery

et al. 2021

BMC Musculoskelet Disord

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Background Hereditary multiple exostoses (HME) is a rare skeletal disorder characterised by a widespread. distribution of osteochondromas originating from the metaphyses of long bones. Case presentation This case study examines a 55-year-old male cadaver bequeathed to the University of Liverpool who suffered from HME, thus providing an exceptionally rare opportunity to examine the anatomical changes associated with this condition. Conclusions Findings from imaging and dissection indicated that this was a severe case of HME in terms of the quantity and distribution of the osteochondromas and the number of synostoses present. In addition, the existence of enchondromas and the appearance of gaps within the trabeculae of affected bones make this a remarkable case. This study provides a comprehensive overview of the morbidity of the disease as well as adding to the growing evidence that diseases concerning benign cartilaginous tumours may be part of a spectrum rather than distinct entities.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An unusual example of hereditary multiple exostoses: a case report and review of the literature

Chilvers

Gallagher

Jeffery

et al. 2021

BMC Musculoskelet Disord

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“…On reviewing the literature, a total of 207 articles were published from 2004 to August 2020, of which 92 articles 4 …”

Section: Discussionmentioning

confidence: 99%

Osteochondroma Arising From the Inferior Articular Process of the Lumbar Spine in a Geriatric Patient: A Case Report and Literature Review

Lin

Chen

et al. 2022

Geriatr Orthop Surg Rehabil

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Objective Spinal osteochondromas are rare, and approximately less than 5% occur as spinal lesions. We report the case of a solitary osteochondroma of the spine and review and update the literature on spinal osteochondroma, including surgical treatment and subsequent results. Case Description A 73-year-old female patient complained of a 10-year history of back pain and a 4-year history of right-side lower extremity radiating pain with paresthesia. Computed tomography and magnetic resonance imaging (MRI) revealed a bony mass arising from the inferior articular process (IAP) of L3, presenting with features of compressive spinal stenosis at the L3–L4 level. The treatment strategy included the complete marginal excision of the lesion through the posterior approach, as well as complete decompression of the spinal canal and nerve roots. The patient’s symptoms resolved after surgery, and histopathological examination identified the lesion as an osteochondroma. Review Results This review study included 168 solitary osteochondroma cases. The most commonly involved spinal level was cervical (51.8%), and the most frequent spinal anatomic column involved was the posterior column (70.8%). Radiculopathy accounted for 30.3% of all cases, myelopathy accounted for 31.0%, and 7.7% exhibited both symptoms simultaneously. The recurrence rate was 6.0%. Conclusion Computed tomography and MRI can effectively diagnose spinal osteochondroma, and surgical treatment can effectively improve clinical outcomes. In almost all symptomatic cases, the best treatment is marginal excision of the tumor. Complete resection of the cartilaginous cap of the tumor is especially important to prevent recurrence.

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Osteochondroma of The Spine: a Rare Case Report

Lay, MD,

Gendedy Toembi Tumanggor, MD

2024

IJRP

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Introduction: Osteochondroma is the most common benign bone tumor, accounting for 36% of benign bone tumors. Most commonly found in long bones, reports show that spinal osteochondroma is relatively rare, accounting for only 4% to 7% of primary benign spinal tumors.Case Report: A 29-year-old man came to the outpatient polyclinic of Haji Adam Malik General Hospital Medan with complaints of weakness in the lower limbs since 2013. The patient had a history of trauma in which he was hit by a pedicab in September 2012, Physical examination of the local status of the rear area shows that on inspection abnormal bony prominence was found, on palpation a palpable mass was found on the lumbar area sized 2 x 2 cm, and limited range of motion of the thoracolumbar area due to weakness. Whole Spine MRI without contrast showed straight thoracolumbar and degenerative marrow disease with bulging of L4-5 and L5-S1 discs pressing against the spinal canal. Mass on the right side of Th 11 to L1 involving the right multifidus lumborum muscle and right longissimus thoracis muscle, attached to the arch up to the spinous process compresses the spinal canal and the right side of the neural foramen. TREATMENT: The treatment of this patient is an open biopsy, tumor excision, Th10-12 laminectomy, and Th9-Th10-L1 posterior stabilization.Discussion: Total tumor resection is recommended for neurological repair and to reduce the risk of malignant transformation, although the risk of malignant transformation remains low. Spinal fusion and posterior instrumentation may be required to prevent spinal instability after extensive laminectomy in surgical procedures. In this case, the fusion procedure is performed and showed excellent clinical outcome after total resection of spinal osteochondromas. In this patient, there was no significant motor improvement, but sensory improvement was found at right and left L3 levels compared to the preoperative baseline. Conclusion:Patients with spinal osteochondroma are rare cases. MRI and biopsy are tests that can be used to confirm the diagnosis. The best approach to this treatment is excision of the tumor. Careful surgical excision with complete resection is important to prevent recurrence.

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Multiple hereditary osteochondromatosis with spinal cord compression: case report

Abstract: A detailed family history through examination-guided advanced imaging and biopsy provides useful information for diagnosis and appropriate management of occupative lesions in patients affected with multiple hereditary exostosis.

Cited by 3 publications

References 19 publications

An unusual example of hereditary multiple exostoses: a case report and review of the literature

An unusual example of hereditary multiple exostoses: a case report and review of the literature

Osteochondroma Arising From the Inferior Articular Process of the Lumbar Spine in a Geriatric Patient: A Case Report and Literature Review

Osteochondroma of The Spine: a Rare Case Report

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