Multiple heteroatom-doped photoluminescent carbon dots for ratiometric detection of Hg²⁺ ions in cell imaging and environmental applications

Abstract

Photoluminescent detection and imaging of Hg2+ ions in the biochemical living system are of great importance. In this study, a new photoluminescent probe based on nitrogen (N), sulfur (S), and...

Carbon Dots for Intracellular Sensing

“…Moreover, intracellular Hg 2+ sensing was realized by Mohandoss et al based on that the addition of Hg 2+ could induce a large redshift of CDs from 452 to 496 nm. [ 266 ] To achieve this, nitrogen (N)‐, sulfur (S)‐, and boron (B)‐doped CDs (NSB‐CDs) were synthesized from methionine sulfoxide and phenylboronic acid (PBA) via a hydrothermal approach. The presence of 0–30 μM Hg 2+ ions enhanced the fluorescence of NSB‐CDs at 496 nm and decreased the fluorescence of NSB‐CDs at 452 nm, enabling ratiometric detection of Hg 2+ .…”

Tenofovir antiviral drug solubility enhancement with β-cyclodextrin inclusion complex and in silico study of potential inhibitor against SARS-CoV-2 main protease (Mpro)

“…Natural or modified CDs have been demonstrated by Loftsson to be able to shield unstable molecules and boost their bioavailability by making them more soluble in physiological conditions [18] . During the last decade, our rsearch group have focusd mainly on nanomaterials, drug complexation properties and other applications [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] . In vitro cell cultures have demonstrated that cholesterol depletion by CDs disturbs the lipid content of the host cell membrane, limiting the virus's ability to bind to protein receptors [29] , [30] , [31] .…”

Ratiometric Multimode Detection of pH and Fe3+ by Dual-Emissive Heteroatom-Doped Carbon Dots for Living Cell Applications

“…Recently, fluorescence-based ratiometric chemo- and biosensors have drawn enormous research attention because of their numerous advantages, such as trace-level detection of analytes, improved accuracy, and high reliability. − Ratiometric detection offers the benefit of visual recognition because while one emission band increases, the other band either remains unaffected or may decrease. Ratiometric techniques are self-calibrating methods, eliminating interference and improving sensitivity because of the dual emissions at different wavelengths. − However, designing a ratiometric fluorescence probe is challenging, as it needs suitable fluorophores with different emissive states for a particular excitation wavelength.…”