Multiple Hormone Resistance in Short Children Born with Intrauterine Growth Retardation?

Chatelain, Pierre; Nicolino, Marc; Claris, Olivier; Chaussain, Jean‐Louis

doi:10.1159/000053082

Cited by 34 publications

(25 citation statements)

References 12 publications

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“…However, while some studies report GHD and decreased plasma IGF-I concentrations (Woodall et al 1996, Albertsson-Wikland et al 1998, others report resistance to GH, IGF-I and/or insulin in the presence of normal GH, IGF-I and insulin profiles (Gluckman & Harding 1997, Chatelain et al 1998. Furthermore, it has been shown that GH secretion, either spontaneous or evoked, is blunted in obesity (Scacchi et al 1999).…”

Section: Discussionmentioning

confidence: 99%

Adult growth hormone treatment reduces hypertension and obesity induced by an adverse prenatal environment

Vickers

Ikenasio²,

Breier³

2002

Journal of Endocrinology

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The discovery of a link between an adverse in utero environment and the propensity to develop metabolic and cardiovascular disease in adult life is one of the most important advances in epidemiological research of recent years. Increasing experimental evidence suggests that alterations in the fetal environment may have long-term consequences for the development of metabolic disorders in adult life. This process has been termed 'fetal programming' and we have shown that undernutrition of the mother during gestation leads to development of the metabolic syndrome X during adult life. Striking metabolic similarities exist between syndrome X and untreated GH deficiency (GHD). In the present study we have investigated the effects of GH treatment on blood pressure and metabolic parameters. Virgin Wistar rats (age 75 5 days, n=20 per group) were time-mated and randomly assigned to receive food either ad libitum (AD) or 30% of AD intake (UN) throughout pregnancy. At weaning, male offspring were assigned to one of two diets (control or hypercaloric (30% fat)). Systolic blood pressure was measured at day 100 and following twice daily treatment with recombinant bovine GH for 21 days. GH treatment increased body weights in all treated animals but significantly reduced retroperitoneal and gonadal fat pad weights. Following GH treatment, systolic blood pressure was markedly decreased in all UN offspring. Salinetreated animals showed no change in systolic blood pressure over the treatment period. GH treatment increased heart-to-body weight ratio in all GH-treated animals. Our data demonstrated that GH treatment reduces hypertension and improves cardiovascular function in animals exposed to adverse environmental conditions during fetal or postnatal life.

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Section: Discussionmentioning

confidence: 99%

Adult growth hormone treatment reduces hypertension and obesity induced by an adverse prenatal environment

Vickers

Ikenasio²,

Breier³

2002

Journal of Endocrinology

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“…The primary hormonal regulators of postnatal growth are growth hormone (GH) and insulin-like growth factor-I (IGF-I), whereby the growth capacity of peripheral tissues appears to depend on the response to GH, hepatic IGF-I and locally synthesized IGF-I (D' Ercole et al 1984, Cohick & Clemmons 1993. Subnormal GH secretion and reduced IGF-I levels are described in a subset of short IUGR children (ThieriotPrevost et al 1988, De Waal et al 1994, AlbertssonWikland et al 1998; however, GH resistance may also play a role in the inability to grow properly after IUGR (Gluckman & Harding 1997, Chatelain et al 1998.…”

Section: Introductionmentioning

confidence: 99%

Endocrine regulation and extended follow up of longitudinal growth in intrauterine growth-retarded rats

Houdijk

Engelbregt²,

Popp-Snijders³

et al. 2000

Journal of Endocrinology

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Bilateral uterine artery ligation in late gestation was performed in pregnant dams in order to determine the effects of intrauterine growth retardation (IUGR) on long-term postnatal somatic growth and the GH neuroendocrine axis in the adult female and male rat. Body weight (BW), nose-anus length (NAL) and tail length (TL) were recorded at regular intervals in both the IUGR and control (CON) offspring until the age of 93 days. Spontaneous 6-h GH secretory profiles and serum IGF-I were determined around the age of 100 days in both the IUGR and the CON group.No catch-up growth in BW, NAL or TL was observed in young adult male IUGR rats. Female IUGR rats did catch up in NAL beyond the age of 57 days and in TL before weaning, but did not catch up at any time in BW. Spontaneous 6-h GH secretory profiles in female and male IUGR rats at a mean age of 100 4 days were similar to their controls at a mean age of 101 4 days. Overall median 6-h rat GH plasma concentrations, rat GH peak amplitude, number of rat GH peaks and sum of peak area were not significantly different. Median serum IGF-I levels in young adult female and male IUGR rats showed no difference when compared with their respective controls.These results demonstrate that IUGR, after bilateral uterine artery ligation in late gestation, leads to incomplete BW catch-up growth in young adult rats of both sexes with physiological GH/IGF-I secretion, suggesting intrauterine modulation of tissue responsiveness to GH and IGF-I. Female IUGR rats do catch up in NAL and TL, developing disturbed body proportions.

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“…However, despite being shorter and thinner, the IGF-I levels in our short SGA children were not lower compared with short normal-birthweight controls. It has been suggested that short SGA children may have a degree of IGF-I resistance as higher basal and GH-induced IGF-I levels are required to achieve a growth velocity similar to that of other children (40). Relative IGF-I resistance at the pituitary could contribute to the elevated GH secretion seen in our short SGA children, and would also be compatible with the observation that supra-physiologic GH doses are required to significantly improve final height prognosis in short SGA children (41)(42)(43).…”

mentioning

confidence: 99%

The Somatotropic Axis in Short Children Born Small for Gestational Age: Relation to Insulin Resistance

et al. 2002

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Multiple Hormone Resistance in Short Children Born with Intrauterine Growth Retardation?

Cited by 34 publications

References 12 publications

Adult growth hormone treatment reduces hypertension and obesity induced by an adverse prenatal environment

Adult growth hormone treatment reduces hypertension and obesity induced by an adverse prenatal environment

Endocrine regulation and extended follow up of longitudinal growth in intrauterine growth-retarded rats

The Somatotropic Axis in Short Children Born Small for Gestational Age: Relation to Insulin Resistance

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