2008
DOI: 10.2174/138920208785133280
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Multiple Hsp70 Isoforms in the Eukaryotic Cytosol: Mere Redundancy or Functional Specificity?

Abstract: Hsp70 molecular chaperones play a variety of functions in every organism, cell type and organelle, and their activities have been implicated in a number of human pathologies, ranging from cancer to neurodegenerative diseases. The functions, regulations and structure of Hsp70s were intensively studied for about three decades, yet much still remains to be learned about these essential folding enzymes. Genome sequencing efforts revealed that most genomes contain multiple members of the Hsp70 family, some of which… Show more

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Cited by 105 publications
(118 citation statements)
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References 148 publications
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“…Although this is not particularly surprising in light of the modest phenotypic effects, in agreement with the original biochemical studies characterising SSA1 or SSB1 deletions (reviewed in 28), it is interesting from a molecular network perspective given the many interactions mediated by the two HSP70s. We next attempted to rationalise these effects by modelling the loss of the HSP70 in theoretical network calculations.…”
Section: Resultssupporting
confidence: 70%
See 1 more Smart Citation
“…Although this is not particularly surprising in light of the modest phenotypic effects, in agreement with the original biochemical studies characterising SSA1 or SSB1 deletions (reviewed in 28), it is interesting from a molecular network perspective given the many interactions mediated by the two HSP70s. We next attempted to rationalise these effects by modelling the loss of the HSP70 in theoretical network calculations.…”
Section: Resultssupporting
confidence: 70%
“…However, despite these similarities, SSA1 and SSA2 are differentially regulated 26; SSA1 expression is highly increased at 39°C while SSA2 transcript abundance increases only marginally in higher temperatures. A number of other studies have also pointed to functional specificity, as reviewed by Kabani and Martineau 28. Furthermore, when grown on a non‐fermentable carbon source and at 37°C, the SSA1 mutant strain is inviable whilst cells deleted for SSA2 grow normally 27.…”
Section: Introductionmentioning
confidence: 95%
“…The presence of dnaK in archaeal genomes is not always verified, in remarkable contrast with all bacteria and eukaryotes [63,64]. It was proposed that dnaK and its companion co-chaperones, dnaJ and grpE , were acquired by Halobacteriales from bacteria, lost and reacquired [65,66].…”
Section: Resultsmentioning
confidence: 99%
“…On the one hand the redundancy may indicate the requirement of chaperones in different compartments to mediate protein folding. On the other hand, it also reflects that chaperones are not generally promiscuous towards their substrates and that cells also require highly specialized chaperones for distinct functions (Hageman et al, 2011;Kabani and Martineau, 2008). Moreover, it has been shown in a recent study that some HSPs exhibit tissueor development specific expression which further makes the folding environment of cells highly dynamic (Hageman and Kampinga, 2009).…”
Section: Vi6 Analysis Of Intra-compartmental Proteostasis Capacity mentioning
confidence: 99%