Teeth that cease to erupt before emergence to their functional position in the oral cavity are termed as impacted. Impaction of teeth can result firstly from local biomechanical impediments, and secondarily from childhood maxillofacial or dentoalveolar trauma, reconstructive surgery of the facial skeleton, malpositioning of an adjacent tooth, thickened overlying osseous or mucosal tissues, insufficient maxillofacial skeletal development or a low correlation between maxillofacial skeletal development and tooth maturation, eruption disturbances and owing to direct or indirect effects of cysts or neoplasm. In permanent dentition, third molars are the most frequently impacted teeth followed by the canines. When few teeth are impacted, the condition is localized, but multiple teeth are impacted, the condition becomes generalized and is often associated with some derangement of the normal physiological processes. Therefore, factors causing impactions may be localized, pertaining to the area or, systemic or, generalized including bone disorders such as cleidocranial dysplasia and/or some sort of endocrinological disturbance such as hypoparathyroidism. Hypoparathyroidism is a rare endocrinological disorder accompanied by anomalies of various systems including bones and teeth. The dental defects due to hypoparathyroidism may present as hypocalcaemia, aplasia and/or hypoplasia, defects of mineralization, short and blunted roots, delayed eruptions, and clinically missing or impacted teeth. This report presents two interesting cases, where multiple impacted permanent teeth and retained primary teeth, wear accompanied by clinical manifestations in two female patients of 27 and 51 years of age which called for further investigations and, eventually, aided in the early diagnosis of hypoparathyroidism.