Multiple infection with<i>Toxocara canis.</i>Influence of antihistamines and corticosteroids on the histopathological response

Zyngier, Felix R.; G, Santarosa

doi:10.1080/00034983.1976.11687145

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…Recently we examined the impact of single versus multiple exposures to T. canis (4). In this situation, we anticipated a more heightened and sustained host immune reaction to secondary and subsequent infections of the parasite (44)(45)(46)(47)(48)(49)(50). Prior work had noted that the pattern of larval distribution in various organ systems is different in rodents given single versus multiple doses of T. canis (51)(52)(53).…”

Section: Immunological Considerationmentioning

confidence: 99%

The consequences of parasitic infection for the behavior of the mammalian host.

Donovick

Burright

1987

Environ Health Perspect

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As many as one billion people may be infected with animal parasites. The behavioral consequences of such infection, or of illness in general, is poorly understood. This issue is discussed using as an example infection of mice with Toxocara canis, the common roundworm of dogs. Current literature suggests that two-thirds of all dogs have been infected with this parasite, and 7% of all humans have antibodies to T. canis. T. canis completes its life cycle in dogs, but when it infects aberrant mammalian hosts (e.g., humans or mice), larvae migrate through various organ systems including the brain, where they can remain viable and mobile for extended periods of time. Changes in motor activity, sensory reactivity, and learning of mice infected with T. canis have been observed. The pattern of behavioral changes is influenced by the infection regime and exposure to other toxicants such as lead.

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Section: Immunological Considerationmentioning

confidence: 99%

The consequences of parasitic infection for the behavior of the mammalian host.

Donovick

Burright

1987

Environ Health Perspect

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“…Whether the pathological changes and clinical signs were due to the parasite's passage through mice, variation in the host species, or the strain of parasite is unclear. Zyngier and Santa Rosa [17] and Dunsmore et al [18] suspected that there may be strain differences in T. canis . Our experiments in mice, rabbits, and monkeys demonstrated acute pathological changes in different organs.…”

Section: Discussionmentioning

confidence: 99%

Development of Some Larval Nematodes in Experimental and Natural Animal Hosts: An Insight into Development of Pathological Lesions vis‐a‐vis Host‐Parasite Interactions

Chowdhury

Sood

Rai

et al. 2013

The Scientific World Journal

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Infective third-stage larvae of three spiruroid nematodes, Ascarops strongylina and Physocephalus sexalatus of pigs and Spirocerca lupi of dogs, were recovered from 14 species of coprophagous beetles belonging to 4 different genera. These larvae were fed to rabbits and/or guinea pigs to study their development in these experimental hosts. Larvae of A. strongylina reached the adult stage in all rabbits and one guinea pig. The adult worms recovered in these hosts were 40% and 4%, respectively, and became diminutive in comparison to their natural hosts. The larvae of P. sexalatus became reencysted in the gastric wall of rabbits inducing marked pathological changes. The infective larvae of S. lupi became reencapsulated in the stomach wall of the rabbit and also showed development in the aortic wall. Adults of Toxocara canis of dog, collected from 5 different regions of the Indian subcontinent, varied significantly in size. The mouse passage of infective larvae of one of these types led to the recovery of the adults from the experimental dogs that were smaller in size and caused severe pathology in natural experimental hosts. Developmental effects shown in experimental hosts and host specificity are of value in understanding the evolution of nematode parasitism.

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