Multiple Infections and Cancer: Etiology, Mechanisms and Implications in Cancer Control

Verma, Mukesh

doi:10.1007/978-3-319-20669-1_8

Cited by 2 publications

(2 citation statements)

References 145 publications

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“…including strains and species) infecting the same species of plant, animal or bacterial host [3,4,5,6]. Though they have indirectly been studied through microbiological experiments for decades [7], multiple infections are nowadays an active research topic in human [8,9] and veterinary [10] medicine and in phytopathology [11]. This recent shift in focus is stimulated by new technologies that make it easier to detect within-host parasitic diversity (see e.g.…”

Section: Introductionmentioning

confidence: 99%

Exposing the diversity of multiple infection patterns

Sofonea

Alizon

Michalakis

2017

Journal of Theoretical Biology

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Natural populations often have to cope with genetically distinct parasites that can coexist, or not, within the same hosts. Theoretical models addressing the evolution of virulence have considered two within host infection outcomes, namely superinfection and coinfection. The field somehow became limited by this dichotomy that does not correspond to an empirical reality as other infection patterns, namely sets of within-host infection outcomes, are possible. We indeed formally prove there are over one hundred different infection patterns solely for recoverable chronic infections caused by two genetically distinct horizontally-transmitted microparasites. We afterwards highlight eight infection patterns using an explicit modelling of within-host dynamics that captures a large range of ecological interactions, five of which have been neglected so far. To clarify the terminology related to multiple infections, we introduce terms describing these new relevant patterns and illustrate them with existing biological systems. These infection patterns constitute a new framework for linking within-host and between-host dynamics, which is a requirement to forward our understanding of the epidemiology and the evolution of parasites.

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Section: Introductionmentioning

confidence: 99%

Exposing the diversity of multiple infection patterns

Sofonea

Alizon

Michalakis

2017

Journal of Theoretical Biology

View full text Add to dashboard Cite

show abstract

“…Though they have indirectly been studied through microbiological experiments for decades [7], multiple infections are nowadays an active research topic in human [8,9] and veterinary [10] medicine and in phytopathology [11]. This recent shift in focus is stimulated by new technologies that make it 30 easier to detect within-host parasitic diversity (see e.g.…”

Section: Introductionmentioning

confidence: 99%

Exposing the Diversity of Multiple Infection Patterns

Sofonea

Alizon

Michalakis

2016

Preprint

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Natural populations often have to cope with genetically distinct parasites that can coexist, or not, within the same hosts. Theoretical models addressing the evolution of virulence have considered two 10 within host infection outcomes, namely superinfection and coinfection. The field somehow became limited by this dichotomy that does not correspond to an empirical reality, as other infection patterns, namely sets of within-host infection outcomes, are possible. We indeed formally prove there are 114 different infection patterns for the sole recoverable chronic infections caused by horizontally-transmitted microparasites. We afterwards highlight eight infection patterns using an explicit modelling of within-15 host dynamics that captures a large range of ecological interactions, five of which have been neglected so far. To clarify the terminology related to multiple infections, we introduce terms describing these new relevant patterns and illustrate them with existing biological systems. This characterisation of infection patterns opens new perspectives for understanding the epidemiology and the evolution of parasites.20

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Multiple Infections and Cancer: Etiology, Mechanisms and Implications in Cancer Control

Cited by 2 publications

References 145 publications

Exposing the diversity of multiple infection patterns

Exposing the diversity of multiple infection patterns

Exposing the Diversity of Multiple Infection Patterns

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