Multiple Inhibitory Mechanisms of Lidocaine on Bradykinin Receptor Activity in Model Sensory Neurons

Hamaya, Chika; Barr, Travis P.; Strichartz, Gary R.

doi:10.1097/aap.0000000000000758

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…In Xenopus oocytes, lidocaine inhibits the response to BK in a time-dependent manner after incubation for 3, 5, or 10 minutes. [ 50 ] There have been some reports about the effect of local anesthetics on to Gαq/11 G protein GPCRs, such as substance P receptor neurokinin-1 receptor(NK-1R) [ 51 ] and endothelin receptor, under the action of their respective endogenous agonists, substance P and endothelin 1, which are released in response to injury and contribute to postoperative pain. In the future, we will further explore the mechanism of the analgesic effect of lidocaine.…”

Section: Effect Of Lidocaine On G-protein-coupled Receptor (Gpcrs)mentioning

confidence: 99%

A review of the mechanism of the central analgesic effect of lidocaine

Yang

Wei

et al. 2020

Medicine

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Lidocaine, as the only local anesthetic approved for intravenous administration in the clinic, can relieve neuropathic pain, hyperalgesia, and complex regional pain syndrome. Intravenous injection of lidocaine during surgery is considered as an effective strategy to control postoperative pain, but the mechanism of its analgesic effect has not been fully elucidated. This paper intends to review recent studies on the mechanism of the analgesic effect of lidocaine. To the end, we conducted an electronic search of the PubMed database. The search period was from 5 years before June 2019. Lidocaine was used as the search term. A total of 659 documents were obtained, we included 17 articles. These articles combined with the 34 articles found by hand searching made up the 51 articles that were ultimately included. We reviewed the analgesic mechanism of lidocaine in the central nervous system.

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Section: Effect Of Lidocaine On G-protein-coupled Receptor (Gpcrs)mentioning

confidence: 99%

A review of the mechanism of the central analgesic effect of lidocaine

Yang

Wei

et al. 2020

Medicine

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“…Local anesthetics have been shown to be equally effective to corticosteroid combined with local anesthetic in an overwhelming majority of patients. Extensive mechanisms have been proposed to describe the effects of epidural local anesthetic, as well as steroids with effects on nociceptive activity (49)(50)(51)(52)(53)(54)(55)(56)(57)(58); to some extent that may also be exerted by sodium chloride solution, however, the literature is scant.…”

Section: Discussionmentioning

confidence: 99%

“…It also has been described that proponents of epidural steroids continue to overlook that most commonly used agent, methylprednisolone, may be effective, based on a reversible, local anesthetic effect (48). Thus extensive mechanisms of long-lasting effects of local anesthetics based on neural blockade altering nociceptive input, the reflex mechanism of afferent fibers, self-sustaining activity of the neurons, and the pattern of central neuronal activities have been proposed (49)(50)(51)(52)(53)(54)(55)(56)(57)(58). Additionally, studies also have shown that corticosteroid failed to provide any additional significant benefit in nerve infiltration for lumbar disc herniation (54).…”

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confidence: 99%

Is Epidural Injection of Sodium Chloride Solution a True Placebo or an Active Control Agent? A Systematic Review and Meta-Analysis

et al. 2020

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BACKGROUND: Epidural injections have been extensively used since their description in 1901, and steroids since their first utilization in 1952. Multiple randomized controlled trials and systematic reviews have reached discordant conclusions regarding the effectiveness of sodium chloride solution and steroids in managing spinal pain. True placebo-controlled trials with the injection of an inactive substance to unrelated structures have been nonexistent. Consequently, the discussions continue to escalate, seemingly without proper discourse. In this review, we sought to assess the true placebo nature of saline and the effectiveness of steroids. OBJECTIVES: This assessment of sodium chloride solution is undertaken to assess if it is a true placebo when injected into the epidural space, is effective alone, and whether steroids are effective when injected with sodium chloride solution rather than local anesthetic in managing spinal pain. STUDY DESIGN: A systematic review of randomized controlled trials utilizing sodium chloride solution alone, steroids alone, or sodium chloride solution with steroids in managing spinal pain secondary to disc herniation or spinal stenosis. METHODS: The systematic review was performed utilizing Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Cochrane review criteria and Interventional Pain Management techniques--Quality Appraisal of Reliability and Risk of Bias Assessment (IPM–QRB) was used to assess the methodological quality assessment. Qualitative analysis was performed by utilizing best evidence synthesis principles, and quantitative analysis was performed utilizing meta-analysis with conventional methodology and single-arm meta-analysis. PubMed, Cochrane Library, US National Guideline Clearinghouse, Google Scholar, and prior systematic reviews and reference lists were utilized in the literature search from 1966 through December 2018. The evidence was summarized utilizing principles of best evidence synthesis on a scale of 1 to 5. Outcome measures for the present analysis, 20% improvement from the baseline pain scores or disability scores was considered clinically significant. Effectiveness was determined short-term if it was less than 6 months, whereas longer than 6 months was considered to be long-term. RESULTS: Of the 8 trials meeting inclusion criteria, 2 trials utilized fluoroscopic imaging and one study utilized ultrasound. All other studies performed the procedure without fluoroscopy. With dual-arm meta-analysis, there was no significant difference between epidural sodium chloride solution and epidural steroids with sodium chloride solution. Utilizing single-arm analysis, both epidural saline and epidural steroids with saline were effective in reducing 20% of pain, however, only reducing disability scores by 10% to 12%. Based on the qualitative analysis, epidural saline and epidural steroids with saline showed effect beyond placebo and showed level I, or strong evidence, that neither epidural saline, nor epidural steroids with saline are placebo and that both are effective. LIMITATIONS: Despite 8 randomized controlled trials, only 2 of them utilized fluoroscopy. Overall evidence is considered less than optimal and further studies elucidating these actions are strongly recommended. CONCLUSIONS: The findings of this systematic review and meta-analysis show that epidurally administered sodium chloride solution and sodium chloride solution with steroids may be effective in managing low back and lower extremity pain. Consequently, the findings of this review provide information that epidurally administered sodium chloride solution is not a true placebo. KEY WORDS: Chronic low back pain, epidural injections, local anesthetic, sodium chloride solution, steroids, placebo effect

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“…Ich blokada hamuje pobudliwość komórek nerwowych i receptorów bólowych w nerwach obwodowych oraz w grzbietowych neuronach rdzenia kręgowego [8]. Do innych działań zalicza się blokowanie receptorów dla bradykininy, co może mieć wpływ na hamowanie reakcji zapalnej oraz bólu [9], modulację działania błonowych receptorów przejściowego potencjału (TRP -transient receptor potential) [10], blokadę receptorów sprzężonych z białkiem G (GCRP -receptory sprzężone z białkami G) [11]. Kolejnym prawdopodobnym działaniem lidokainy podanej dożylnie jest ośrodkowe hamowanie działania neuroprzekaźnika pobudzającego -glutaminianu na receptory NMDA [12].…”

Section: Lidokaina Jako Koanalgetyk O Działaniu Wielokierunkowymunclassified

Lidocaine, old drug - new possibilities. Treatment of postoperative pain and reduction of postoperative complications with intravenous administration

Kamil

Wesołowski

Sebastian

et al. 2022

J Educ Health Sport

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Introduction: The number of surgeries requiring sedation continues to increase worldwide. Analgesia is one of the main components of anesthesia used during surgical procedures. Despite improvements in surgical techniques, the invention of new analgesics and a significant expansion of knowledge about the pathophysiology of pain, more than 75% of patients experience postoperative pain. Adequate analgesia reduces postoperative complications and shortens the length of hospitalization. Lidocaine is a local anesthetic also used as an antiarrhythmic drug. Studies report that intravenous administration may find application in perioperative analgesia. Aim of the study: The purpose of our study was to determine in which types of surgery the benefits of IVL (Intravenous lidocaine) are greatest.Methods and Evidence: We reviewed the literature available on PubMed using the words "Intravenous lidocaine"; "Perioperative Lidocaine "; "Postoperative pain".Results: IVL has been shown to have a positive effect on reducing opioid doses, postoperative pain intensity, shortening the duration of postoperative bowel obstruction, faster patient rehabilitation and shortening hospitalization. In non-abdominal surgeries, the greatest benefits have been seen in breast surgery, urology and spinal surgery. Lidocaine has low toxicity; only doses several times higher cause adverse effects.Conclusions: IVL should be used during intraabdominal surgery due to its high efficacy. Further studies on a larger group of patients are needed to better determine the effects of IVL in other surgeries. Keywords: "Intravenous lidocaine"; "Perioperative Lidocaine "; "Postoperative pain".

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Multiple Inhibitory Mechanisms of Lidocaine on Bradykinin Receptor Activity in Model Sensory Neurons

Abstract: At subclinical concentrations, lidocaine suppresses BK's activation of model sensory neurons. This effect adds to the known analgesic mechanisms of LAs and likely contributes to the reduction of postincisional pain.

Cited by 5 publications

References 25 publications

A review of the mechanism of the central analgesic effect of lidocaine

A review of the mechanism of the central analgesic effect of lidocaine

Is Epidural Injection of Sodium Chloride Solution a True Placebo or an Active Control Agent? A Systematic Review and Meta-Analysis

Lidocaine, old drug - new possibilities. Treatment of postoperative pain and reduction of postoperative complications with intravenous administration

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