Multiple Interdigital Neuromas: A Retrospective Study of 279 Feet With 462 Neuromas

Diagnostic Value of Elastography in the Diagnosis of Intermetatarsal Neuroma

“…Multiple neuromas were reported by Valero et al (38) to be more frequent (65.2% of all cases) than previously thought. In contrast, we observed multiple neuromas in 7 of 18 patients (38.9%).…”

“…Interdigital neuroma histopathologic findings include intraneural and perineural fibrosis, increased arteriolar blood vessels and decreased calibration of blood vessels, edema of the endoneurium, axonal degeneration, infiltration of leukocytes, and epineural and endoneural vascular hyalinization (2,5,6,38) (Fig. 2).…”

Ultrasound-guided intervention in the ankle and foot

“…[61][62][63] It is caused by nerve fibre degeneration and excessive intraneural and juxtaneural reparative fibrosis. It is therefore not a true nerve tumour but rather represents a perineural fibroma as the result of impingement and microdamage to the common digital nerve, caused by several factors, including excessive weight-bearing stress, inflammatory bursitis, ischaemia, entrapment of the metatarsal nerve and compression by the metatarsal ligament.…”

“…MNs are usually multiple, with a predilection for the third common digital nerve and commonly affect middle-aged females and athletes. [61][62][63] MN presents as burning pain or paraesthesia at the forefoot radiating to the toes. Symptoms are aggravated by walking in tight high-heeled shoes and may be relieved by removing shoes and massaging.…”

“…Symptoms are aggravated by walking in tight high-heeled shoes and may be relieved by removing shoes and massaging. [61][62][63] To help provide an accurate clinical assessment, a number of provocative tests can be performed. Although there is no single pathognomonic test, the thumb index finger test and the Mulder's click are the most sensitive and specific, resulting, respectively, in pain and a palpable click at the site of the suspected MN.…”