Multiple intestinal atresias associated with angiodysplasia in a newborn

Guzmán, Miguel A.; Prasad, Rajeev; Duke, Duane S.; Chadarévian, Jean‐Pierre de

doi:10.1016/j.jpedsurg.2011.02.004

Cited by 2 publications

(5 citation statements)

References 19 publications

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“…First, pathologic examination in adults reveals dilated, tortuous, thin-walled vessels mainly in the submucosa. In contrast, most pediatric patients, including our patient, had ectatic vessels spreading to the subserosa and some had an elastic lamina; these findings are consistent with AVMs [10,11].…”

Section: Discussionsupporting

confidence: 80%

“…In addition, intestinal angiodysplasia in the adult population is usually thought to be an acquired degenerative vascular lesion related to aging and associated factors such as aortic stenosis, renal failure, or coagulopathy [4,6,7,10,11]. The lesions of angiodysplasia may occur in any part of the intestine, most notably in the cecum or ascending colon in adults.…”

Section: Discussionmentioning

confidence: 99%

“…An AVM might be an important cause of GI bleeding because a previous study showed that doubleballoon or capsule endoscopy revealed an AVM in 6.3 to 18.1% of children with occult GI bleeding who underwent examinations by double-balloon endoscopy or capsule endoscopy [13,14]. AVMs also cause wideranging clinical problems such as bowel atresia, perforation [10], and intussusception [15]. To the best of our knowledge, only three cases of AVM-related intussusception have been published, as reported by Lim et al [15].…”

Section: Discussionmentioning

confidence: 99%

“…Angiodysplasia is often used to describe AVMs in the intestine of older adults. However, this condition has rarely been reported in the pediatric population [3][4][5][6][7][8][9][10][11]. Gastrointestinal (GI) bleeding is the main symptom in patients of all ages.…”

Section: Introductionmentioning

confidence: 99%

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Arteriovenous malformation that caused prolapse of the colon and was treated surgically in an infant: a case report

Kido¹,

Nakamura²,

Kuwahara³

et al. 2020

surg case rep

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Background: Various terms have been used to describe vascular lesions in the intestine, including angiodysplasia, arteriovenous malformation, and telangiectasia. Such lesions are common in adults and are typified by angiodysplasia, a type of arteriovenous malformation. In contrast, these lesions are rarely seen in the pediatric population. Angiodysplasia may cause gastrointestinal bleeding, which is sometimes an indication for treatment. Considering the high rate of recurrence after surgical treatment, conservative treatments are mainly chosen. We herein report an extremely rare case of a prolapsed colon due to an arteriovenous malformation successfully treated by resection in a 1-year-old girl. We also highlight the differences between pediatric and adult cases. Case presentation: A girl developed bloody stools at 7 months of age. She visited another hospital at 1 year of age because of continuing moderate hematochezia and recent onset of rectal prolapse. Colonoscopy showed a protruding lesion located 15 cm from the anal verge, suggesting a submucosal vascular abnormality. Contrastenhanced computed tomography and magnetic resonance imaging at our hospital revealed the localized lesion with dilated blood vessels in part of the sigmoid colon; no other lesions were present in the gastrointestinal tract. Laparoscopic-assisted sigmoidectomy was performed. A subserosal vascular lesion was visualized and resected using end-to-end anastomosis. Pathologic examination of the 2.2 × 2.7-cm segment revealed several abnormally enlarged and ectatic blood vessels in the submucosa extending into the subserosa. The lesion was diagnosed as an arteriovenous malformation. The patient had a good clinical course without recurrence at the 2-year follow-up. Conclusions: An arteriovenous malformation in the sigmoid colon may rarely cause intussusception and prolapse of the colon. Complete resection is a radical and potentially effective treatment. Computed tomography and colonoscopy were useful for evaluation of the lesion in the present case.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Arteriovenous malformation that caused prolapse of the colon and was treated surgically in an infant: a case report

Kido¹,

Nakamura²,

Kuwahara³

et al. 2020

surg case rep

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“…Many of these conditions including intestinal atresia, motility disorders, Hirschprung’s disease, and gastrointestinal stromal tumors (GIST) have multiple and incompletely understood etiologies (Louw and Barnard, 1955; Mazur and Clark, 1983; Sanders, 1996; Hirota et al, 1998; Newgreen and Young, 2002; Heanue and Pachnis, 2007; Streutker et al, 2007; Appelman, 2011; Guzman et al, 2011). One of the difficulties in deciphering the mechanisms underlying these diseases is the lack of information available on the development of a major component of the gut tube—the intestinal mesoderm.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive timeline of mesodermal development in the quail small intestine

Thomason

Bader

Winters

2012

Developmental Dynamics

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Background To generate the mature intestine, splanchnic mesoderm diversifies into six different tissue layers each with multiple cell types through concurrent and complex morphogenetic events. Hindering the progress of research in the field is the lack of a detailed description of the fundamental morphological changes that constitute development of the intestinal mesoderm. Results We utilized immunofluorescence and morphometric analyses of wild type and Tg(tie1:H2B-eYFP) quail embryos to establish a comprehensive timeline of mesodermal development in the avian intestine. The following landmark features were analyzed from appearance of the intestinal primordium through generation of the definitive structure: radial compartment formation, basement membrane dynamics, mesothelial differentiation, mesenchymal expansion and growth patterns, smooth muscle differentiation, and maturation of the vasculature. In this way, structural relationships between mesodermal components were identified over time. Conclusions This integrated analysis presents a roadmap for investigators and clinicians to evaluate diverse experimental data obtained at individual stages of intestinal development within the longitudinal context of intestinal morphogenesis.

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Multiple intestinal atresias associated with angiodysplasia in a newborn

Cited by 2 publications

References 19 publications

Arteriovenous malformation that caused prolapse of the colon and was treated surgically in an infant: a case report

Arteriovenous malformation that caused prolapse of the colon and was treated surgically in an infant: a case report

Comprehensive timeline of mesodermal development in the quail small intestine

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