Multiple intracranial tumors: Coexistence of a glioblastoma and null cell pituitary adenoma within the same patient

Hacıyakupoğlu, Ersin; Sav, Aydın; Hacıyakupoğlu, Sebahattin; Walter, Jan

doi:10.1016/j.clineuro.2014.03.002

Cited by 6 publications

(7 citation statements)

References 5 publications

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“…Died 3 months later from recurrent GBM.4Haciyakupoglu et al . [1]61/MHeadache refractory to Analgesics, nausea, vomiting, and fatigability.All pituitary hormones within normal ranges.Rt. frontal tumor mass of and suprasellar massGBM and null cell pituitary adenoma.Dexamethasone, removal of the frontal lesion and subsequent transcranial removal of the suprasellar tumor.Adjuvant RTx/CMT.…”

Section: Discussionmentioning

confidence: 99%

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Glioblastoma and prolactinoma: a rare simultaneous occurrence

Alshalawi

Alkhaibary

Basalamah

et al. 2019

Journal of Surgical Case Reports

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The simultaneous development of two or more primary central nervous system (CNS) tumors of different cell types represents 0.9% of all diagnosed CNS tumors. To the best of our knowledge, the simultaneous occurrence of glioblastoma and pituitary adenomas has been reported four times in the English literature, with only two cases harboring prolactinoma and glioblastoma. We report a case of a 42-year-old male who was diagnosed with a sporadic co-occurrence of glioblastoma and a prolactin-secreting pituitary adenoma (prolactinoma). This case report discusses the clinical presentation, radiological/histopathological features, and outcome as well as reviewing the pertinent medical literature. Glioblastoma and a prolactin-secreting adenoma may be detected within the same patient. Further studies are required to delineate the tumorigenesis of the development and co-occurrence of multiple intracranial tumors.

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Section: Discussionmentioning

confidence: 99%

“…The simultaneous development of two or more primary CNS tumors of different cell origin is extraordinarily rare with an incidence rate of <0.9% of all primary CNS tumors [1]. The most common combination of primary brain tumors is: meningioma and glioma, meningioma and neurinoma, followed by meningioma and pituitary adenoma [2].…”

Section: Introductionmentioning

confidence: 99%

Glioblastoma and prolactinoma: a rare simultaneous occurrence

Alshalawi

Alkhaibary

Basalamah

et al. 2019

Journal of Surgical Case Reports

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“…However, this coexistence is rarely reported in the pertinent literature [9]. To our knowledge, only five cases of this coexistence have been previously reported [1,3,[9][10][11]. Among these, three cases were prolactinomas, and the remaining cases were nonfunctioning PA. All of GBMs from the five case reports located in the cerebral cortices which is the common location of GBM.…”

Section: Introductionmentioning

confidence: 93%

“…PA is often found as an incidental finding in radiographic imaging, [8] whereas GBM is one of the most common primary CNS tumors. However, this coexistence is rarely reported in the pertinent literature [9]. To our knowledge, only five cases of this coexistence have been previously reported [1,3,[9][10][11].…”

Section: Introductionmentioning

confidence: 94%

Concurrent Pituitary Adenoma and Intraventricular Glioblastoma Multiforme: A Case Report and Review of the Literature

Chattrabongkot¹,

Raywat²

2022

Neurosurg Cases Rev

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“…It not only has the characteristics of space-occupying lesions but also is an endocrine gland tumor, which can affect the body's metabolism and trigger a variety of endocrine diseases. 2 With the development of detection methods, it was shown in recent reports that the detection rate is about 15%-20%. 3 At present, surgical treatment is the main treatment for pituitary tumor, mainly including craniotomy via frontal and temporal approach and transsphenoidal surgery.…”

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confidence: 99%

Clinical study of pituitary tumors with EEA resection and its influence on the expression of tumor necrosis factor-α, interleukin-6, and interleukin-12 in patients

Wang

Zhong

Cheng³

et al. 2019

Eur J Inflamm

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The aim of this study is to investigate the efficacy of expanded endonasal approaches (EEAs) in the treatment of pituitary adenoma, and the effects of serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-12 (IL-12) in patients were further analyzed. A total of 80 cases of patients with pituitary adenoma admitted to our hospital from January 2013 to May 2015 were randomly divided into the observation group and control group, with 40 cases in each group. The observation group was treated with EEA technique, while the control group was treated with transcranial microsurgery. The prolactin (PRL), growth hormone (GH) and other endocrine hormone indexes, as well as inflammatory factors such as TNF-α, IL-6, and IL-12 were compared before and 1 week after the operation between the two groups. Moreover, the scores of Karnofsky performance status (KPS) and Mini-Mental State Examination (MMSE) at preoperative and postoperative 1 week were also compared between the two groups. The operation time, hospitalization time, and postoperative complications were compared between the two groups. And the patients were followed up for 2 years to observe the recurrence rate. The operation time and hospital stay in the observation group were 62.8 ± 9.3 min and 12.5 ± 2.1 days, respectively, while the operation time and length of stay in the control group were 105.6 ± 15.7 min and 18.2 ± 3.4 days, respectively. The operation time and hospitalization time were shorter than those in the control group, and the differences were statistically significant (P < 0.05). Before surgery, there was no significant difference in serum levels of PRL and GH between the two groups (P > 0.05). At 1 week after surgery, the levels of PRL and GH in the two groups were significantly lower than those before surgery (P < 0.05). And the serum levels of PRL and GH in the observation group were significantly lower than those in the observation group at 1 week after the operation (P < 0.05). Before operation, there was no significant difference between the two groups of KPS and MMSE scores (P > 0.05). At 1 week after operation, the scores of KPS and MMSE in both groups were significantly higher than those before the operation (P < 0.05), and the scores of KPS and MMSE in the observation group were significantly higher than those in the control group (P < 0.05). Furthermore, there was no significant difference in the serum levels of IL-6, IL-12, and TNF-α between the two groups before operation (P > 0.05). At 1 week after surgery, the serum levels of IL-6, IL-12, and TNF-α in the two groups were significantly lower than those before surgery (P < 0.05), while the serum levels of IL-6, IL-12, and TNF-α in the observation group were evidently lower than those in the control group at 1 week after the operation. Besides, the incidence of postoperative complications in the observation group was 7.5%, which was significantly lower than that in the control group (17.5%) (P < 0.05). All the patients in the two groups were followed up for 2 ye...

show abstract

Multiple intracranial tumors: Coexistence of a glioblastoma and null cell pituitary adenoma within the same patient

Cited by 6 publications

References 5 publications

Glioblastoma and prolactinoma: a rare simultaneous occurrence

Glioblastoma and prolactinoma: a rare simultaneous occurrence

Concurrent Pituitary Adenoma and Intraventricular Glioblastoma Multiforme: A Case Report and Review of the Literature

Clinical study of pituitary tumors with EEA resection and its influence on the expression of tumor necrosis factor-α, interleukin-6, and interleukin-12 in patients

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