Multiple Intraperitoneal Transfusions of the Fetus for Erythroblastosis Fetalis

Bowman, John M.; Friesen, Rhinehart F.

doi:10.1056/nejm196410012711403

Cited by 32 publications

(2 citation statements)

References 5 publications

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“…Candidates for amniocentesis, upon which the decision to carry out intrauterine transfusion de¬ pends, are determined on the basis of history of previously affected infants and antibody titer.1 Amniocentesis is initially carried out at 20 to 22 weeks gestation and is repeated at 4-to 14-day 3. Serial amniotic fluid examinations in an Rh-negative isoimmunized pregnancy; the mother had had two fetuses which died from erythroblastosis.…”

Section: Methodsmentioning

confidence: 99%

Fetal Transfusion in Severe Rh Isoimmunization

Bowman¹

1969

JAMA

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Section: Methodsmentioning

confidence: 99%

Fetal Transfusion in Severe Rh Isoimmunization

Bowman¹

1969

JAMA

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“…The baby, a son named Paul, was delivered by Friesen on April 20, 1964 at 34.5 weeks gestation, required three exchange transfusions, and thrived. 26 (In Winnipeg, at fetal transfusion the obstetrician, using a Tuohy needle, placed the epidural catheter in the fetal peritoneal cavity; Bowman, who regarded the fetus as his patient, infused the red cells through the catheter).…”

Section: Intrauterine Fetal Transfusionmentioning

confidence: 99%

From Tragedy to Triumph: Canadian Connections in the Management of Rhesus Hemolytic Disease of the Newborn

Baskett

2019

Journal of Obstetrics and Gynaecology Canada

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J ohn Ballantyne (1861Ballantyne ( -1923 of Edinburgh wrote that the first record of fetal hydrops was given by Hippocrates in The Epidemics with a description of a "fleshy foetus" with "general foetal dropsy." 1 It is probable that the French midwife, Louise Bourgeois (1563-1636), gave the first account of hemolytic disease of the newborn in her 1609 midwifery text. 2 She reported the case of a multiparous woman who delivered twins; one was hydropic and died soon after birth, and the other developed jaundice and died on the fourth day. DEFINITION OF THE DISEASEUntil the 1930s the disease entity we now know as Rhesus (Rh) hemolytic disease of the newborn was not defined and was represented by four, at that time not necessarily related, disorders: hydrops, neonatal jaundice, anemia, and erythroblastosis. This constellation of disorders was first grouped as being from a single cause in 1930 by the Canadian-born John Ferguson (b. 1900) while working as a junior pathologist at Harvard University. 3 In his report of six neonatal deaths with erythroblastosis he concluded that hydrops, jaundice, and erythroblastosis "are probably representative of a definite disease entity of the newly born, and whatever the etiology may be, the underlying cause is undoubtedly the same in each instance." 3 The same conclusion was reached the following year by Diamond and colleagues, with the addition of neonatal anemia to the clinical picture. 4 It was also noted that the disease tended to recur from one pregnancy to the next, but never in the affected woman's first pregnancy. PATHOPHYSIOLOGYRuth Darrow (1895-1956) was a general practitioner in Chicago who worked from her medical office and clinic in the basement of her house and held staff privileges at the Women's and Children's Hospital. 5 In 1935, after two uneventful pregnancies, her third baby, a son, developed severe neonatal jaundice and died: the autopsy showed extensive erythroblastosis. While still in medical practice she dedicated the next 2 years to reviewing all the available literature on erythroblastosis fetalis. She concluded that the mother "poisoned" her own infant with some "toxic substance." Darrow eventually deduced that some fetal red cells must pass through the placenta into the maternal blood and initiate an immune reaction. As she put it: "An antigen-antibody reaction seems to explain best all aspects of these related disorders." 5 Thus, in her lonely one-woman review, she succeeded in accurately delineating the pathophysiological mechanism behind erythroblastosis fetalis that had taken the life of her son. However, she concluded, as had others, 4 that "This mechanism, incidentally, bears no relation to a difference in blood groups in mother and child." 5 The full explanation would await the discovery of the Rh blood antigen.

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Multiple Intrauterine Transfusions for Erythroblastosis Fetalis

Queenan¹

1965

JAMA

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Multiple Intraperitoneal Transfusions of the Fetus for Erythroblastosis Fetalis

Cited by 32 publications

References 5 publications

Fetal Transfusion in Severe Rh Isoimmunization

Fetal Transfusion in Severe Rh Isoimmunization

From Tragedy to Triumph: Canadian Connections in the Management of Rhesus Hemolytic Disease of the Newborn

Multiple Intrauterine Transfusions for Erythroblastosis Fetalis

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