Multiple joint tuberculosis presenting as HLA-B27 disease

Hopkins, G. O.

doi:10.1136/pgmj.59.688.113

Cited by 1 publication

(1 citation statement)

References 4 publications

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“…In most cases, HA materials are considered highly biocompatible and, therefore, suitable for bone tissue applications (e.g., medical implants and bone regeneration) [48,49,50]. However, the response of biological tissues and cell lines to HA-based materials (including HA nanoparticles and nano-objects) shows great variability [51,52,53,54].…”

Section: Biocompatibility Assessment Of Cap-based Bioceramicsmentioning

confidence: 99%

Comprehensive In Vitro Testing of Calcium Phosphate-Based Bioceramics with Orthopedic and Dentistry Applications

et al. 2019

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Recently, a large spectrum of biomaterials emerged, with emphasis on various pure, blended, or doped calcium phosphates (CaPs). Although basic cytocompatibility testing protocols are referred by International Organization for Standardization (ISO) 10993 (parts 1–22), rigorous in vitro testing using cutting-edge technologies should be carried out in order to fully understand the behavior of various biomaterials (whether in bulk or low-dimensional object form) and to better gauge their outcome when implanted. In this review, current molecular techniques are assessed for the in-depth characterization of angiogenic potential, osteogenic capability, and the modulation of oxidative stress and inflammation properties of CaPs and their cation- and/or anion-substituted derivatives. Using such techniques, mechanisms of action of these compounds can be deciphered, highlighting the signaling pathway activation, cross-talk, and modulation by microRNA expression, which in turn can safely pave the road toward a better filtering of the truly functional, application-ready innovative therapeutic bioceramic-based solutions.

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