Multiple keratoacanthomas treated with oral retinoids

Multiple Eruptive Keratoacanthoma and Immunity Disorders

“…(b) surgery: electrocoagulation and curettage or exci sion in to to; (c) synthetic retinoids seem to be the first-choice treat ment [2,8], It seems that the effective dosage is at least 1 mg/kg/day. It is possible that the most important skin lesions regress, while the pruritus persists as do the small follicular milia-like lesions.…”

Hypertrophic Lichen Planus–Like Reactions Combined With Infundibulocystic Hyperplasia

“…2004;140:1262-1267 K ERATOACANTHOMAS USUally arise as solitary lesions but may occasionally present as multiple lesions 1,2 or as unusual variants such as keratoacanthoma marginatum centrifugum or keratoacanthoma en plaque. [3][4][5][6][7] These unusual variants may persist and can be associated with progressive growth and provide difficulties in classification, particularly in reference to squamous cell carcinomas and their treatment.…”

“…[3][4][5][6][7] These unusual variants may persist and can be associated with progressive growth and provide difficulties in classification, particularly in reference to squamous cell carcinomas and their treatment. Retinoids have been used successfully to treat all variants of keratoacanthoma [1][2][3][4][5][6][7][8] and appear to accelerate their involution, possibly by promoting differentiation. The relationship of keratoacanthoma and squamous cell carcinoma has been a subject of debate, and even the use of newer probes capable of quantitating proliferation markers and detecting abnormalities in tumor suppressor genes and upgraded cellular oncogenes has not provided an answer.…”

Multiple Keratoakanthome als Differenzialdiagnose einer Prurigo nodularis bei monoklonaler Gammopathie

“…Topisch angewandte Therapieerfolge, gerade bei generalisiert− eruptiven Keratoakanthomen sind eher nicht zu erwarten [4]. Hier sind systemische Therapien mit Acitretin (Neotigason) ini− tial 0,5 ± 1 mg/kg KG/Tag mit Reduktion auf eine Erhaltungsdosis mit Erfolg eingesetzt worden [8,9] ± im Gegensatz zu der kleine− ren follikulären Variante der KA, die auf die systemische Reti− noidtherapie nicht ansprachen [7]. Des Weiteren werden in der Literatur Remissionen der Erkrankung unter Methotrexat und auch Fallbeispiele mit einer Remission der Erkrankung unter Cy− clophosphamid [3] …”