This paper examines the impact of institutional frameworks on ontologies of 'live-work mix', i.e., the renewed intertwining of residential and economic uses in urban developments. We aim to understand how local housing and planning regimes influence the nature of live-work mix by comparing three contrasting institutional frameworks (Amsterdam, Brussels, Stockholm), using an institutionalist approach to governance drawing on the concept of path dependency. We address two research questions: how have each city's housing and planning regimes influenced current urban development strategies, and what ontologies of live-work mix do these regimes and strategies underlie. Based on a literature review, document analysis and exploratory interviews, we show that live-work goals are defined in instruments underpinned by different discourses and early planning directions, but in which housing supply is instrumental to economic growth. Market parties play an essential role in implementing these goals as a result of critical junctures and dependencies affecting the actors involved and their governance capacity. Overall, the local ontologies of live-work mix reflect broader city understandings and are either consistently oriented towards attractiveness or, on the contrary, overlapping between, sometimes, antagonistic agendas. Used sensitively, our analytical framework appears to be relevant to understanding the local mitigation of global developments.