Multiple Liver Abscesses with a Skin Pustule due to &lt;i&gt;Chromobacterium violaceum&lt;/i&gt;

Matsuura, N.; Miyoshi, Megumi; Doi, N; Yagi, Saori; Aradono, Etsuko; Imamura, Takuroh; Koga, Rintaro

doi:10.2169/internalmedicine.8682-16

Cited by 5 publications

(8 citation statements)

References 18 publications

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“…Although human infections caused by C. violaceum are rare, more than 200 cases have been reported worldwide [2]. The clinical manifestations of C. violaceum infection greatly vary, which ranges from mild fever, diarrhea, liver abscess, lung abscess, urinary tract infection and abdominal abscess, to rapid fatal sepsis [9]. The relevant clinical manifestations depend on the involved organs.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of a patient with recurrent infection of Chromobacterium violaceum

et al. 2021

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Background Chromobacterium violaceum (C. violaceum) is a Gram-negative saprophytic bacterium that is widespread in tropical and subtropical environments, and belongs to conditional pathogenic bacteria. Human infection with C. violaceum is rare, and this can be fatal when the diagnosis and treatment are delayed, especially recurrent infection patients. Since clinicians lack the knowledge for C. violaceum, rapid diagnosis and early appropriate antimicrobial treatment remains challenging. Case presentation A 15-year-old male student was hospitalized for dark abscess, pustules, severe pain in both legs, and fever for 11 days. There were pustules with gray-white pus and red infiltrating plaques on the back, and the subcutaneous nodules could be touched in front of both tibias, with scab, rupture and necrotic tissue of the lower limb. The patient’s condition rapidly progressed. Therefore, next-generation sequencing (NGS), pustular secretion and blood culture were concurrently performed. The final diagnosis for this patient was C. violaceum infection by NGS. However, no bacterial or fungal growth was observed in the pustular secretion and blood culture. After 4 weeks of treatment, the patient was discharged from the hospital without any complications associated with C. violaceum infection. Conclusion Rapid diagnosis and early appropriate antimicrobial treatment is the key to the successful treatment of C. violaceum infection, especially in patients with sepsis symptoms. This case highlights that NGS is a promising tool for the rapid diagnosis of C. violaceum infection, preventing the delayed diagnosis and misdiagnosis of C. violaceum infection in patients who tested negative for pustular secretion and blood culture.

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Section: Discussionmentioning

confidence: 99%

Successful treatment of a patient with recurrent infection of Chromobacterium violaceum

et al. 2021

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“…The association of Chromobacterium violaceum infection with CGD has been previously described, mainly in children since the hereditary nature of the disease and almost none in adults with skin and soft tissue infections [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Nonetheless, this association does not seem to be directly related to an increase in mortality [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Chromobacterium violaceum Periareolar Infection, First Non-Lethal Case in Colombia: Case Report and Literature Review

Díaz

Martin

Ortiz

et al. 2021

Infectious Disease Reports

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Chromobacterium violaceum is a facultative anaerobic, Gram-negative rod found in different ecosystems, especially tropical and subtropical areas. Human infections are rare, and just a few cases have been reported in literature. In this paper, we present the first non-lethal infection due to Chromobacterium violaceum, in an adult male with polycystic kidney disease in Colombia. Periareolar soft tissue infection was documented with isolation of Chromobacterium violaceum. Clinical manifestations, treatment, and outcome are shown.

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“…Since the first reported case of human infection of C. violaceum from Malaysia in 1927, approximately over 200 cases of human C. violaceum infection have been reported worldwide [ 1 , 7 ]. Currently, only 6 cases from 5 case reports have been presented from Japan, and here we report the first case of death caused by C. violaceum infection in Japan [ 2 – 3 , 8 – 10 ]. In East Asian countries with similar climate conditions, some fatal cases have been reported [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Chromobacterium violaceum ( C. violaceum) is a gram-negative, facultative anaerobic oxidase-positive bacillus [ 1 – 3 ]. As C. violaceum is endemic in natural aquatic environments and is temperature sensitive, it has a predilection for tropical and subtropical areas (latitudes between 35°N and 35°S) [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

The First Fatal Case of Chromobacterium violaceum Infection in Japan

et al. 2021

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Patient: Male, 49-year-old Final Diagnosis: Chromobacterium violaceum infection Symptoms: No symptom Medication:— Clinical Procedure: — Specialty: Infectious Diseases Objective: Rare disease Background: Chromobacterium violaceum ( C. violaceum) is a gram-negative and facultative anaerobic oxidase-positive bacillus generally seen in tropical or subtropical areas (latitudes between 35°N and 35°S). C. violaceum infection is a rare but serious infection with high morbidity and mortality rates. Most clinicians practicing in non-tropical counties, such as Japan, are unfamiliar with it. Case Report: We report the first fatal case of a 49-year-old man infected with C. violaceum after a traffic accident in Japan (latitude 34.8°N). The patient reported brief submergence in a marshy muddy rice field after the accident. There was some evidence of soil and water contamination of the patient’s skin and clothing, but he denied swallowing water or soil. There were no findings of pneumonitis or severe open wounds on admission. Until the night of the 7 th day of hospitalization, his general conditions remained stable despite a persistent fever. However, he suddenly collapsed on the 8 th day of hospitalization and died. C. violaceum bacteremia led to fatal sepsis on dissemination to the iliopsoas abscess, which is a rare combination for this infection. Conclusions: Episodes of exposure to contaminated water or soil, especially in summer, are important predisposing factors for C. violaceum infection. Thus, it is vital to include C. violaceum infections as a differential diagnosis, since the mortality rate of C. violaceum infections is high and the cases of this infection have increased in non-tropical counties.

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Multiple Liver Abscesses with a Skin Pustule due to <i>Chromobacterium violaceum</i>

Cited by 5 publications

References 18 publications

Successful treatment of a patient with recurrent infection of Chromobacterium violaceum

Successful treatment of a patient with recurrent infection of Chromobacterium violaceum

Chromobacterium violaceum Periareolar Infection, First Non-Lethal Case in Colombia: Case Report and Literature Review

The First Fatal Case of Chromobacterium violaceum Infection in Japan

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