Multiple logistic regression analysis predicts cancer risk among tobacco usage with glutathione S-transferase p1 genotyping in patients with head and neck cancer

Argi, Anuradha; Kalpana, V. Lakshmi; Natukula, Kirmani

doi:10.4103/ijc.ijc_277_17

Cited by 1 publication

(2 citation statements)

References 28 publications

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“…We identified 17 unique studies with 24 eligible observations from three locations that are used to estimate the relationship between chewing tobacco and nasopharynx cancer (Fig. 7 ; Supplementary Table S4 ) 44 , 47 , 51 , 53 , 61 , 63 , 65 , 66 , 71 , 72 , 74 , 105 , 112 , 113 , 118 , 120 , 123 , 124 , 130 . All of the studies used case-control study designs and had sample sizes ranging from 219,444 to 141.…”

Section: Resultsmentioning

confidence: 99%

“…We identified 31 unique studies with 43 eligible observations from four locations (Fig. 7; Supplementary Table S4) 36,44,47,51,53,61,63,65,66,[71][72][73][74]84,89,95,97,[103][104][105][106]112,113,115,[118][119][120]123,124,126,127,129,131 . These studies included one prospective cohort study and 30 casecontrol studies with sample sizes ranging from 219,444 to 123.…”

Section: Other Pharynx Cancermentioning

confidence: 99%

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Health effects associated with chewing tobacco: a Burden of Proof study

Gil,

Anderson,

Aravkin

et al. 2024

Nat Commun

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Chewing tobacco use poses serious health risks; yet it has not received as much attention as other tobacco-related products. This study synthesizes existing evidence regarding the health impacts of chewing tobacco while accounting for various sources of uncertainty. We conducted a systematic review and meta-analysis of chewing tobacco and seven health outcomes, drawing on 103 studies published from 1970 to 2023. We use a Burden of Proof meta-analysis to generate conservative risk estimates and find weak-to-moderate evidence that tobacco chewers have an increased risk of stroke, lip and oral cavity cancer, esophageal cancer, nasopharynx cancer, other pharynx cancer, and laryngeal cancer. We additionally find insufficient evidence of an association between chewing tobacco and ischemic heart disease. Our findings highlight a need for policy makers, researchers, and communities at risk to devote greater attention to chewing tobacco by both advancing tobacco control efforts and investing in strengthening the existing evidence base.

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