Multiple melanotic schwannoma

Çulhacı, Nil; Dikicioğlu, Emel; Meteoğlu, İbrahim; Boylu, Şükrü

doi:10.1016/s1092-9134(03)00073-x

Cited by 25 publications

(15 citation statements)

References 8 publications

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“…These tumors were S100 positive but CD34 and CD117 negative and all behaved in a benign fashion. Melanin pigment has been described in schwannomas [5] and amianthoid type calcification has also been encountered. The combination of melanin pigment and psammomatous calcification within a schwannoma occurs in two settings.…”

Section: Discussionmentioning

confidence: 99%

Psammomatous melanotic schwannoma presenting as colonic polyps

2007

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Psammomatous melanotic schwannoma is an uncommon neoplasm that usually occurs in the setting of Carney's complex. They can occur in the gastrointestinal tract with preferential location in the stomach. A 43-year-old female presented with two colonic polyps at routine endoscopy. The patient was asymptomatic and did not have features of Carney's complex. Both polyps were composed of melanin-containing epithelioid and spindle cells with several psammoma bodies. There was no evidence of cytological atypia or necrosis. The tumor was diffusely positive for S-100, and focally for HMB-45 and melan-A. The differential diagnosis includes melanoma, GIST, pigmented neuroendocrine tumor, and epithelioid leiomyoma. The lack of malignant features separates this lesion from melanoma while the immunophenotype of the other lesions is characteristic.

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Section: Discussionmentioning

confidence: 99%

Psammomatous melanotic schwannoma presenting as colonic polyps

2007

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“…Most MS are highly cellular and composed of spindle-shaped and epithelioid cells with an eosinophilic-to-amphophilic cytoplasm. They are distinguishable from classic schwannomas by their heavy pigmentation because of the deposit of melanin pigment in the form of brown-to-black granules in the cytoplasm of both spindled and epithelioid cells (1,4,5,12,15). In 40 to 50% of MS, histological appearance shows fat and laminated calcophites, named psammoma bodies.…”

Section: Case Reportmentioning

confidence: 99%

Melanotic Nonpsammomatous Trigeminal Schwannoma as the First Manifestation of Carney Complex

et al. 2006

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We present the unusual case of a nonpsammomatous trigeminal melanotic schwannoma associated with Carney complex, with confirmed PRKAR1A gene mutation. Our case highlights that neurosurgeons, in the presence of a melanotic schwannoma, should be aware of the features of the Carney complex because, in such cases, pre- and postoperative management is significantly affected. We also postulate that the absence of psammoma bodies or cranial localization do not exclude this diagnosis.

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“…Meningiomas and schwannomas are well-demarcated lesions that may also contain melanin pigment and reveal hyperintensity on the T1 images [3,8], Although most spinal meningiomas are intradural, King et al [7] reported that approximately 2.5% of these are purely extradural. Another melanin-containing lesion, meningeal melanocytoma, is rarely found alone, and may be indistinguishable from a melanoma, even though it is found more commonly in the cervical region [9].…”

Section: Discussionmentioning

confidence: 99%

Primary Thoracic Epidural Melanoma : A Case Report

Kim

et al. 2010

Asian Spine J

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A 68-year-old woman with progressive paraparesis and altered sensation lasting approximately five days was admitted to our clinic. Magnetic resonance imaging (MRI) revealed an advanced stage T7-8 epidural mass ventral to the spinal cord, which was believed to be a metastatic tumor considering the patient's age. A highly enhanced epidural mass and pedicle appeared during the MR scan. However, the pathologic findings were compatible with the diagnosis of a primary meningeal melanocytic tumor. Primary epidural melanomas are extremely rare lesions. This case was finally diagnosed as a primary thoracic spinal epidural melanoma.

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Multiple melanotic schwannoma

Cited by 25 publications

References 8 publications

Psammomatous melanotic schwannoma presenting as colonic polyps

Psammomatous melanotic schwannoma presenting as colonic polyps

Melanotic Nonpsammomatous Trigeminal Schwannoma as the First Manifestation of Carney Complex

Primary Thoracic Epidural Melanoma : A Case Report

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