Multiple metastasized extramammary Paget's disease cured with bisphosphonate risedronate sodium after CyberKnife radiosurgery and docetaxel chemotherapy

Fujimura, Taku; Furudate, Sadanori; Kambayashi, Yahiko; Kakizaki, Aya; Haga, Takahiro; Hashimoto, Akira; Aiba, Setsuya

doi:10.1016/j.dsi.2016.02.001

Cited by 1 publication

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unlike conventional EMPD, immunohistochemical staining in the present case revealed the expression of RANKL but the lack of expression of MMP7 on Paget's cells. As we previously reported, Paget's cells express RANKL and MMP7 [ 6 , 12 ], release sRANKL in the tumor microenvironment [ 6 ], and stimulate TAMs to produce Tregs-related chemokines, such as CCL17, in conventional EMPD [ 7 ]. Therefore, the lack of MMP7 might abrogate the release of sRANKL, leading to the downregulation of chemokines and MMPs from TAMs.…”

Section: Discussionmentioning

confidence: 99%

RANKL-Expressing Ectopic Extramammary Paget’s Disease on the Lower Abdomen

et al. 2016

Self Cite

View full text Add to dashboard Cite

Ectopic extramammary Paget’s disease (EMPD) is a rare variant of EMPD that develops in nonapocrine regions. Since reports about ectopic EMPD are limited, little is known about the biological and immunological background of ectopic EMPD. In this report, we present a case of ectopic EMPD on the lower abdomen that expressed RANKL but lacked the expression of MMP7. As we previously reported, Paget’s cells express RANKL and MMP7, release soluble RANKL in the tumor microenvironment, and stimulate tumor-associated macrophages to produce tumor-loading factors in conventional EMPD. In our present case, both CCL5-expressing cells and MMP25-bearing cells were lacking, whereas substantial numbers of CCL5-expressing cells and MMP25-bearing cells were found in conventional EMPD. Our case suggested that the lack of MMP7 on Paget’s cells might be one of the possible explanations for the biology of ectopic EMPD.

show abstract