Multiple methicillin-resistant Staphylococcus aureus strains as a cause for a single outbreak of severe disease in hospitalized neonates

Noel, Gary J.; Kreiswirth, Barry N.; Edelson, Paul J.; Nesin, Mirjana; Projan, S J; Eisner, William; Bauer, Daniel J.; Lencastre, Hermı́nia de; Figueiredo, Agnes Marie Sá; Tomasz, Alexander

doi:10.1097/00006454-199203000-00002

Cited by 38 publications

(18 citation statements)

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“…Other investigators have shown worse outcomes with higher rates of invasive disease and severe infections and MRSA-related deaths. 4,12,13 On comparison of case-patients with their corre- sponding control-patients, infants with MRSA infection had a significantly increased length of stay, which suggests increased cost. This reinforces previous reports that earlier and successful eradication of outbreaks is cost-effective.…”

Section: Discussionmentioning

confidence: 99%

Eradication of Methicillin-ResistantStaphylococcus AureusFrom a Neonatal Intensive Care Unit by Active Surveillance and Aggressive Infection Control Measures

Khoury

Jones²,

Grim³

et al. 2005

Infect. Control Hosp. Epidemiol.

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Section: Discussionmentioning

confidence: 99%

Eradication of Methicillin-ResistantStaphylococcus AureusFrom a Neonatal Intensive Care Unit by Active Surveillance and Aggressive Infection Control Measures

Khoury

Jones²,

Grim³

et al. 2005

Infect. Control Hosp. Epidemiol.

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“…Methicillin-resistant Staphylococcus aureus (MRSA)-colonized patients appear to be at substantial risk of MRSA infection during hospitalization and after discharge from the hospital [1][2][3] . Moreover, MRSA carriers play an important role in spreading MRSA to their family members and community contacts [4][5][6] , resulting in the in-hospital spread of MRSA at the time of readmission [7][8][9] .…”

confidence: 99%

Clinical Outcomes in Methicillin-Resistant <i>Staphylococcus aureus-</i>Colonized Neonates in the Neonatal Intensive Care Unit

Kim

Chang²,

Kim³

et al. 2006

Neonatology

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Background: Methicillin-resistent Staphylococcus aureus (MRSA) colonization can persist for prolonged periods, and patient-related factors are associated with persistent carriage in adults. However, such knowledge is lacking among neonates. Objectives: To better understand the outcome of MRSA-colonized neonates in the neonatal intensive care unit (NICU), we prospectively followed all colonized neonates until decolonization over 39 months and determined the incidence, duration of colonization, clinical outcomes and risk factors associated with prolonged carriage of MRSA. Methods: Nasal and inguinal cultures were obtained from all newly admitted neonates following an outbreak of MRSA. Weekly and 1–2 monthly cultures were obtained from all hospitalized and discharged neonates colonized with MRSA, respectively, until 2 consecutive cultures were negative. Results: 152 of 1,456 (10.4%) neonates became colonized. The mean time to acquire MRSA colonization was 17.1 ± 40.7 (range 1–471) days. The median time to decolonization was 36 days. About 20% of decolonized patients had been colonized for a prolonged period of ≧160 days. 47.5% of colonized patients were sent home colonized, and none with prolonged carriage developed MRSA-related infections in the following 6 months in contrast to 6 infants (3.9%) who developed MRSA sepsis during hospitalization. The only risk factor associated with prolonged carriage was the concurrent colonization of both the inguinal and nasal areas on admission. Conclusion:Nearly all neonates with acquired colonization became decolonized either prior to or after discharge from NICU. A significant percentage failed to decolonize prior to hospital discharge, but almost all decolonized by 30 months in the community without evidence of systemic or local infections.

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“…31,32 The agarose inserted DNA was digested with Cla I (Amersham Bioscience do Brasil Ltda) and conventional electrophoresis was run at 38 V for 16 h in 1 £ TAE buffer. DNA fragments were transferred to nylon membranes and hybridized with specific probes for mecA and Tn554.…”

Section: Probe Preparationmentioning

confidence: 99%

Detection and molecular characterization of a gentamicin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) clone in Rio de Janeiro that resembles the New York/Japanese clone

Melo

Silva-Carvalho

Ferreira

et al. 2004

Journal of Hospital Infection

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Multiple methicillin-resistant Staphylococcus aureus strains as a cause for a single outbreak of severe disease in hospitalized neonates

Cited by 38 publications

References 0 publications

Eradication of Methicillin-ResistantStaphylococcus AureusFrom a Neonatal Intensive Care Unit by Active Surveillance and Aggressive Infection Control Measures

Eradication of Methicillin-ResistantStaphylococcus AureusFrom a Neonatal Intensive Care Unit by Active Surveillance and Aggressive Infection Control Measures

Clinical Outcomes in Methicillin-Resistant <i>Staphylococcus aureus-</i>Colonized Neonates in the Neonatal Intensive Care Unit

Detection and molecular characterization of a gentamicin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) clone in Rio de Janeiro that resembles the New York/Japanese clone

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