Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial

Hoang, N.T.D.; Orellana, Liliana; Gibson, Rosalind S.; Le, Tuyen; Worsley, Anthony; Sinclair, Andrew J.; Hoang, Nghien T.T.; Szymlek‐Gay, Ewa A.

doi:10.1038/s41598-021-83129-9

Cited by 6 publications

(5 citation statements)

References 65 publications

(81 reference statements)

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“…Iron and zinc have also been found to be involved in appetite regulation, and their supplementation has resulted in improved appetite in young children with evidence of growth faltering in previous studies ( 27 , 31 , 68 ). The prevalence of zinc deficiency in Vietnam is high—estimated to be 51.9 and 12.9% for zinc- and iron-deficiencies, respectively, among children aged 6–75 months in 2009 ( 69 ); and 41.4 and 2.4%, respectively, among children aged 6–9 years in 2016 ( 70 ). In undernourished children, such as in the current study population, prevalence of deficiencies is likely to be higher.…”

Section: Discussionmentioning

confidence: 99%

Oral nutritional supplementation with dietary counseling improves linear catch-up growth and health outcomes in children with or at risk of undernutrition: a randomized controlled trial

Ow,

Tran,

Berde

et al. 2024

Front. Nutr.

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IntroductionChildhood undernutrition is associated with increased morbidity, mortality and a high socio-economic burden.MethodsSupporting Pediatric GRowth and Health OUTcomes (SPROUT) is a randomized, controlled trial evaluating the effects of an oral nutritional supplement (ONS) with dietary counseling (DC; n = 164) compared to a DC-only group who continued consuming their habitual milk (n = 166; NCT05239208). Children aged 24–60 months who were at risk or with undernutrition, as defined by weight-for-age [WAZ] < −1 and height-for-age [HAZ] < −1 according to the WHO Growth Standards, and who also met the criterion of weight-for-height [WHZ] < 0, were enrolled in Vietnam.ResultsONS + DC had a larger WAZ increase at day 120 (primary endpoint) vs. DC (least squares mean, LSM (SE): 0.30 (0.02) vs. 0.13 (0.02); p < 0.001), and larger improvements in all weight, BMI and weight-for-height indices at day 30 and 120 (all p < 0.01). Height gain was larger in ONS + DC in all indices, including height-for-age difference [HAD; cm: 0.56 (0.07) vs. 0.10 (0.07); p < 0.001], at day 120. ONS + DC had larger arm muscle but not arm fat indices, higher parent-rated appetite, physical activity and energy levels, longer night sleep, fewer and shorter awakenings, and better sleep quality than DC.ConclusionAdding ONS to DC, compared to DC-alone, improves growth in weight and height, linear catch-up growth, and health outcomes in children with or at risk of undernutrition.

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Section: Discussionmentioning

confidence: 99%

Oral nutritional supplementation with dietary counseling improves linear catch-up growth and health outcomes in children with or at risk of undernutrition: a randomized controlled trial

Ow,

Tran,

Berde

et al. 2024

Front. Nutr.

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“…Mineral status was not reported in either of these studies and is rarely reported in other similar trials. More commonly, concentrations of plasma minerals and trace elements were assessed after direct use of supplemental micronutrient powders or ready to use foods to increase zinc and iron levels 55 , 56 .…”

Section: Discussionmentioning

confidence: 99%

Plasma mineral status after a six-month intervention providing one egg per day to young Malawian children: a randomized controlled trial

Perez-Plazola

Diaz

Stewart

et al. 2023

Sci Rep

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Mineral deficiencies are common in children living in low-resource areas. Eggs are a rich source of essential nutrients and have been shown to improve growth in young children, although little is known about their impact on mineral status. Children aged 6–9 months (n = 660) were randomized to receive either one egg/day for 6-months or no intervention. Anthropometric data, dietary recalls, and venous blood were collected at baseline and 6-months follow-up. Quantification of plasma minerals (n = 387) was done using inductively coupled plasma-mass spectroscopy. Difference-in-difference mean plasma mineral concentrations was determined from baseline and follow-up values and assessed between groups by intention-to-treat using ANCOVA regression models. Prevalence of zinc deficiency was 57.4% at baseline and 60.5% at follow-up. Mean difference (MD) of plasma magnesium, selenium, copper, and zinc levels were not different between groups. Plasma iron concentrations were significantly lower in the intervention compared to the control group (MD = − 9.29; 95% CI: − 15.95, − 2.64). Zinc deficiency was widely prevalent in this population. Mineral deficiencies were not addressed with the egg intervention. Further interventions are needed to improve the mineral status of young children.

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“…Findings regarding the increase in serum zinc level in this study are consistent with the results of previously conducted MNP trials in under-five children [ 37 , 38 ]. A randomized control trial, conducted in Vietnam, found a considerable reduction (17.3%) in the plasma zinc level in 6–9-year-old children [ 39 ]. A study conducted by García-Guerra et al, which examined the impact of MNP supplements on the serum zinc levels of infants aged 6–12 months, administered 6 days per week for 4 months, showed a significant increase in plasma zinc level [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Impact of Multiple Micronutrient Supplementation on Micronutrient Status, Hemoglobin Level, and Growth in Children 24 to 59 Months of Age: A Non-Randomized Community-Based Trial from Pakistan

et al. 2023

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Cost-effective interventions are needed to address undernutrition, particularly micronutrient deficiencies, which are common in children under the age of five in low- and middle-income countries. A community-based, non-randomized clinical trial was undertaken in the Kurram district of Khyber Pakhtunkhwa from January 2018 to June 2019, to evaluate the effect of locally produced micronutrient powder (local name: Vita-Mixe) on plasma micronutrient status, hemoglobin level, and anthropometric outcomes. Children aged 24–48 months old were recruited and allocated to the intervention and control arm of the study. The enrolled children in the intervention arm received one micronutrient powder (MNP) sachet for consumption on alternate days for 12 months. To assess the impact of the intervention on plasma levels of zinc, vitamin D, vitamin A, and hemoglobin level, blood samples were taken at baseline and after one year following the intervention. The analysis was conducted using Enzyme-Linked Immunosorbent Assay (ELISA), atomic absorption spectrometry, and an automated hematology analyzer. For the impact on growth parameters, the anthropometric assessment was performed using WHO standard guidelines. A 24 h dietary recall interview was used to assess the nutrient intake adequacy. Results showed that in the intervention arm, children had on average a 7.52 ng/mL (95% CI 5.11–9.92, p-value < 0.001) increase in the plasma level of vitamin A, 4.80 ng/mL (95% CI 1.63–7.95, p-value < 0.002) increase in vitamin D levels and 33.85 µg/dL (95% CI 24.40–43.30, p-value < 0.001) increase in the plasma zinc level, as well as a 2.0g/dL (95% CI 1.64–2.40, p-value < 0.001) increase in hemoglobin level. Statistically significant improvement was observed in the weight-for-height z-score (WHZ) (from −1.0 ± 0.88 to −0.40 ± 1.01, p < 0.001) and weight-for-age z-score (WAZ) (from −1.40 ± 0.50 to −1.05 ± 0.49, p < 0.001) in the intervention group compared to the control group. No statistically significant change was observed in the height-for-age z-score (HAZ) in the intervention group (p = 0.93). In conclusion, micronutrient powder supplementation is a cost-effective intervention to improve the micronutrient status, hemoglobin level, and growth parameters in under-five children, which can be scaled up in the existing health system to address the alarming rates of undernutrition in Pakistan and other developing countries.

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Multiple micronutrient supplementation improves micronutrient status in primary school children in Hai Phong City, Vietnam: a randomised controlled trial

Cited by 6 publications

References 65 publications

Oral nutritional supplementation with dietary counseling improves linear catch-up growth and health outcomes in children with or at risk of undernutrition: a randomized controlled trial

Oral nutritional supplementation with dietary counseling improves linear catch-up growth and health outcomes in children with or at risk of undernutrition: a randomized controlled trial

Plasma mineral status after a six-month intervention providing one egg per day to young Malawian children: a randomized controlled trial

Long-Term Impact of Multiple Micronutrient Supplementation on Micronutrient Status, Hemoglobin Level, and Growth in Children 24 to 59 Months of Age: A Non-Randomized Community-Based Trial from Pakistan

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