Multiple molecular simultaneous imaging in a live mouse using semiconductor Compton camera

Abstract

We have demonstrated the feasibility of semiconductor Compton cameras for multiple molecular imaging in nuclear medicine. The Compton camera used in this work comprises two double-sided orthogonal-strip germanium detectors, and their excellent energy resolution enabled discrimination of the nuclides and accurate determination of the scattering angle for g rays in wide energy range. Three radioactive tracers of 65 ZnCl 2 , 85 SrCl 2 , and iodinated ( 131 I) methylnorcholestenol were injected to a living mouse and were measured simultaneously. Both two-and three-dimensional images of each tracer were obtained by a fixed-angle imaging with a single Compton camera, which reflected the different in vivo behavior of them.

Multitracing Capability of Double-Scattering Compton Imager With NaI(Tl) Scintillator Absorber

“…This capability was first demonstrated using a Compton camera composed of two segmented germanium detectors for the scatterer and absorber detectors by Yang et al [1]. Recently, they replaced the component detectors with two double-sided strip germanium detectors, and, then, demonstrated the multitracing capability for biological samples (soybean and mouse) [2], [3]. Fig.…”

Cameras shapes for medical imaging Compton cameras

“…In the conventional camera design, the two detectors are planar shaped and parallel to each other [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. Unfortunately, the completeness conditions cannot be satisfied using the conventional shape.…”

Development of multielemental imaging on semiconductor Compton telescope

“…Recently, we were succeeded in imaging dynamic metabolic processes of three radio-active medicines that were simultaneously administered [22]. However, the measurement times taken to obtain the images would be unsuitable for practical imaging, although they can be shortened to about 10 h if more intense γ-ray sources are used.…”