Multiple Myeloma: a Retrospective Analysis of 61 Patients from a Tertiary Care Center

Sultan, Sadia; Irfan, Syed Mohammed; Parveen, Saira; Ali, Hamza; Basharat, Maria

doi:10.7314/apjcp.2016.17.4.1833

Cited by 17 publications

(22 citation statements)

References 11 publications

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“…In the study of Kaushik et al 21 pallor was seen in 94% of the patients which is similar to this study. But it was 44.2% patients in the study of Sultan et al 18 Bone tenderness was in 47% cases observed by Kaushik et al 21 It was lower than the findings in this study possibly due to late stage of presentation in our study.…”

Section: Resultscontrasting

confidence: 72%

“…Hemoglobin value ≤10 gm/dL was seen in 63.9% of the patients in Sultan et al 18 study and in the study of Wadhwa 19 it was in 59% of the patients. These are similar to the present study (62.5%).…”

Section: Resultsmentioning

confidence: 77%

“…Age range of patients was 36−71 years with mean 51.94 ± 10.09 years and median 53 years. 18 . In our study the mean age was 52 years whereas in another study 20 in Bangladesh it was 63 years.…”

Section: Resultsmentioning

confidence: 99%

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A Clinical and Laboratory Profile of Multiple Myeloma

Chowdhury¹

2018

J Enam Med Col

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Background: Myeloma, the most common malignant disease of bone, is incurable and occurring with increasing frequency in elderly population. Typical clinical features are weakness, fatigability, bone pain, anemia, renal insufficiency and hypercalcemia. Incidental discovery on comprehensive laboratory panels is common. Serum or urine protein electrophoresis or immunofixation and bone marrow aspirate analysis help the diagnosis of multiple myeloma.Objective: The aim of this study was to define and evaluate the clinico-laboratory features of newly diagnosed adult multiple myeloma (MM) patients in the context of Bangladesh.Materials and Methods: This study was carried out in two centers, from October 2005 to January 2010 in Bangabandhu Sheikh Mujib Medical University (BSMMU) and July 2012 to June 2017 in Enam Medical College and Hospital (EMCH). Thirty two diagnosed valid cases of multiple myeloma were included in this study. Clinical history, physical and relevant laboratory findings were carefully recorded and analyzed.Results: In this study among 32 patients, 29 were males and 3 were females with mean age 51.94 ± 10.09 years. The common complaints were bone pain, weakness and fatigue. The common clinical findings were bone tenderness, pallor and high ESR (ESR of all the study patients was more than 100 mm in 1st hour). Hemoglobin level was <8.5 gm/dL in 13 patients, serum creatinine ≥2 mg/dL in seven patients, serum albumin <30 mg/L in 14 patients and serum β2 microglobulin >5.5 mg/L in 15 patients. Three patients were hypercalcemic. Lytic lesions were the most common radiological finding in the study.Conclusion: This study showed that multiple myeloma is a disease of the middle and elderly aged population with male preponderance, with high male female ratio. Multivenued studies are needed to view the real picture of multiple myeloma in the context of Bangladesh.J Enam Med Col 2018; 8(3): 159-164

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Section: Resultscontrasting

confidence: 72%

Section: Resultsmentioning

confidence: 77%

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A Clinical and Laboratory Profile of Multiple Myeloma

Chowdhury¹

2018

J Enam Med Col

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“…This manifestation caused them to visit the hospital and obtained a proper diagnosis and initiate therapy. Sultan et al, (2016) also stated that the majority of 61 MM patients presented fatigue (81.9%) and backaches (80.3%). The radiological survey showed 78.6% of them reported bone lesions included punched-out lytic lesions, osteoporosis or fractures.…”

Section: Discussionmentioning

confidence: 94%

Health- Related Quality of Life for Multiple Myeloma Patients with Bone Metastases in Indonesia: A Cross-Sectional Study

Sayuti

Andayani

Endarti

et al. 2019

Asian Pac J Cancer Prev

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Objective: Multiple myeloma (MM) with bone metastases causes a skeletal-related event (SRE), and decreases health-related quality of life (HRQoL). HRQoL needs to be evaluated for health technology assessment (HTA). Furthermore, HRQoL is calculated as a health state utility and is used in the Markov Model for HTA. Therefore, this study aimed to describe the HRQoL of MM patients with bone metastases, using The EuroQol five-dimension five levels (EQ-5D-5L) in Indonesia. Methods: a cross-sectional, multicenter study for MM patients with bone metastases (aged over 18 years old) that consulted a physician between November 2018-May 2019 was conducted. The calculated HRQoL illustrated the health state utility, which was assessed using the EQ-5D-5L questionnaire, with the Indonesian value set. In addition, Mann-Whitney analyses were performed to determine the difference in utility scores at different points within the Durie-Salmon staging system and skeletal condition. Results: in 93 patients who completed the questioner, pain was their major concern with prevalence of over 60% (all levels inclusive). Moreover, the mean utility of patients in stage II and III were 0.735 (SD = 0.205) and 0.383 (SD = 0.555), and those without SRE was 0.753 (SD = 0.213) while patients with SRE was 0.302 (SD = 0.562). Therefore, the lessened values were observed at stage III and SRE condition (p<0.05). Conclusion: MM patients with bone metastases have poor HRQoL, with pain as the most frequently reported challenge, which is associated with an advanced stage of MM and SRE event.

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“…Some of the pain is due to the primary disease,[22] while some could be due to the spread[23] and some due to the treatment. [24] Damage that takes place to the nerves is due to the disease process or chemotherapy that leads to neuropathic pain that presents a different challenge to the physician.…”

Section: Discussionmentioning

confidence: 99%

Integration of specialized pain control services in palliative care: A nationwide web-based survey

Page

2017

Indian J Palliat Care

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Introduction:Pain control is an important part of palliative care (PC), and conventional analgesics do not provide adequate pain relief to all patients. Many patients present with complex pain syndromes that require interventional pain control measures usually deployed by pain specialists. There is adequate integration of specialized pain control services with PC elsewhere, but information about the same in our country is lacking.Materials and Methods:An internet survey was conducted among palliative specialists regarding the need and availability of pain specialists for their patients suffering from complex pain syndromes. Their attitude toward integrating specialized pain control services in their practice was also explored.Results:Majority of palliative physicians came across situations where specialists in pain would control the patients’ pain better. There was a poor availability of such services, and when available, the cost was significant. It is heartening to note that though there is poor integration of specialized pain control services with palliation, palliative physicians acknowledge the need for pain specialists and their techniques for providing pain relief for their patients.Conclusions:Effective pain control is needed in palliation, barriers however exist, and there is a need to make pain specialists and interventional techniques more freely available.

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Multiple Myeloma: a Retrospective Analysis of 61 Patients from a Tertiary Care Center

Cited by 17 publications

References 11 publications

A Clinical and Laboratory Profile of Multiple Myeloma

A Clinical and Laboratory Profile of Multiple Myeloma

Health- Related Quality of Life for Multiple Myeloma Patients with Bone Metastases in Indonesia: A Cross-Sectional Study

Integration of specialized pain control services in palliative care: A nationwide web-based survey

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