Multiple Myeloma Complicated by Autoimmune Hemolytic Anemia

Wada, Hideho; Yata, Kenichiro; Mikami, Makoto; Suemori, Shinichiro; Nakanishi, Hiroyuki; Kondo, Toshinori; Tsujioka, Takayuki; Suetsugu, Yoshimasa; Otsuki, Takemi; Sadahira, Yoshito; Yawata, Yoshihito; Sugihara, Takashi

doi:10.2169/internalmedicine.43.595

Cited by 18 publications

(22 citation statements)

References 5 publications

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“…However, the relationship of the M-protein to autoimmune hemolysis has remained unclear. 7 Nevertheless, the possibility of a druginduced immune-mediated hemolysis in this patient was eliminated since the direct antiglobulin test was negative ( Table 1).…”

Section: Discussionmentioning

confidence: 87%

Transiently Pink-Tinged Serum in a Patient With Multiple Myeloma and Anemia Undergoing Lenalidomide Treatment

Wedel

Sofronescu

2015

American Journal of Clinical Pathology

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Section: Discussionmentioning

confidence: 87%

Transiently Pink-Tinged Serum in a Patient With Multiple Myeloma and Anemia Undergoing Lenalidomide Treatment

Wedel

Sofronescu

2015

American Journal of Clinical Pathology

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“…Autoimmunity is a common manifestation in other hematological malignancies most importantly with chronic On pubmed/medline search, we found four cases of multiple myeloma with autoimmune hemolytic anemia reported in English literature [3][4][5][6]. It is unclear whether AIHA is a result of multiple myeloma or it is just a coincidence.…”

Section: Discussionmentioning

confidence: 99%

Multiple Myeloma Presenting with Autoimmune Hemolytic Anemia

Shah

Uprety

Tretheway

2013

Indian J Hematol Blood Transfus

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“…Autoimmune disorder could also occur in combination with B-cell malignancy, including MM. Wada et al [9] reported a case of MM complicated by autoimmune hemolytic anemia. Terpos et al [10] also reported a case of MM developing SS.…”

Section: Discussionmentioning

confidence: 99%

Mikulicz’s disease with severe thrombocytopenia following autologous stem cell transplantation in a multiple myeloma patient

et al. 2009

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We report the first case of Mikulicz's disease (MD) occurring 2 years after autologous peripheral blood stem cell transplantation (PBSCT) for multiple myeloma (MM). A 70-year-old man developed bilateral enlargement of parotid and submandibular glands. The patient had previously received 2 courses of autologous PBSCT for IgG-kappa type MM, and had been stable for 2 years. This salivary gland enlargement was initially felt to represent a recurrence of MM, since along with gland swelling, IgG was also elevated. However, repeated biopsy of the left submandibular gland revealed chronic sclerosing sialadenitis rather than plasmacytoma. Results of salivary gland scintigraphy, serological testing, and absence of sicca symptoms also supported the diagnosis of MD. Concurrently, the patient developed severe thrombocytopenia (0.8 x 10(4)/microl). Bone marrow biopsy showed abundant megakaryocytes, suggesting enhanced platelet destruction. After high-dose steroid and immunoglobulin therapy, the platelet count gradually returned to normal with complete resolution of the salivary gland enlargement. No apparent signs of MM recurrence were documented during these clinical events.

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Multiple Myeloma Complicated by Autoimmune Hemolytic Anemia

Cited by 18 publications

References 5 publications

Transiently Pink-Tinged Serum in a Patient With Multiple Myeloma and Anemia Undergoing Lenalidomide Treatment

Transiently Pink-Tinged Serum in a Patient With Multiple Myeloma and Anemia Undergoing Lenalidomide Treatment

Multiple Myeloma Presenting with Autoimmune Hemolytic Anemia

Mikulicz’s disease with severe thrombocytopenia following autologous stem cell transplantation in a multiple myeloma patient

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