Multiple Myeloma for the Primary Care Provider: A Practical Review to Promote Earlier Diagnosis Among Diverse Populations

Mıkhael, Joseph; Bhutani, Manisha; Cole, Craig E.

doi:10.1016/j.amjmed.2022.08.030

Cited by 22 publications

(18 citation statements)

References 52 publications

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“…In total, we identified 3 studies[ 21 , 24 , 25 ] that met our selection criteria [Figures 2 - 4 and Table 2 ]. [ 26 27 28 29 30 31 32 33 34 ]…”

Section: Discussionmentioning

confidence: 99%

Lesions of the spinal cord caused by multiple myeloma: A systematic review and meta-analysis regarding the neurosurgical aspects of patient management

Encarnacion,

Chmutin,

Bozkurt

et al. 2023

Journal of Craniovertebral Junction and Spine

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Background: Multiple Myeloma is a B-cell malignancy which can cause variety of lesions of the spine and spinal cord. The management of patients with spinal cord compression (SCC), and the efficacy and security of minimally invasive therapeutic approaches, are the main topics of discussion. Methods: To systematically review the scientific literature on neurosurgical aspects of MM spinal cord lesion management, a search was conducted among scientific papers in the databases ScienceDirect, Cochrane Library, and PubMed using keywords and Boolean operators. These comprise MM and lesions of the spine and spinal cord. Each database was searched from the earliest available article to January 2017. Results: According to the literature, low-dose radiotherapy, antimyeloma medications, and bisphosphonates comprise the mainstay management for symptomatic spinal lesions. The decision to operation is based on presence of myelopathy and degree of spinal cord compression. Conclusions: As a result of the analysis, the following conclusions may be drawn: (1) surgery is a valuable option for MM patients with symptomatic spinal involvement who experience rapid neurological deterioration with SCC and/or mechanical instability and (2) it is important to ensure that the benefits of surgical treatment outweigh the risks, as patients with MM are susceptible to infections.

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“…In total, we identified 3 studies[ 21 , 24 , 25 ] that met our selection criteria [Figures 2 - 4 and Table 2 ]. [ 26 27 28 29 30 31 32 33 34 ]…”

Section: Discussionmentioning

confidence: 99%

Lesions of the spinal cord caused by multiple myeloma: A systematic review and meta-analysis regarding the neurosurgical aspects of patient management

Encarnacion,

Chmutin,

Bozkurt

et al. 2023

Journal of Craniovertebral Junction and Spine

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“… Improving time to diagnosis Approximately two thirds of patients with multiple myeloma arrive at their presumed diagnosis through primary care [ 71 ]. Increased education of primary care providers is needed to facilitate both the suspicion of the diagnosis and the confirmation of the diagnosis through the accurate ordering of lab tests including the free light chain assay [ 72 ]. Cultivating Cultural competence A culturally competent health care system provides a potential way to improve health outcomes and quality of care among patients.…”

Section: Addressing Barriers To Clinical Carementioning

confidence: 99%

“…Approximately two thirds of patients with multiple myeloma arrive at their presumed diagnosis through primary care [ 71 ]. Increased education of primary care providers is needed to facilitate both the suspicion of the diagnosis and the confirmation of the diagnosis through the accurate ordering of lab tests including the free light chain assay [ 72 ].…”

Section: Addressing Barriers To Clinical Carementioning

confidence: 99%

Addressing the disparities: the approach to the African American patient with multiple myeloma

Bhutani,

Blue,

Cole

et al. 2023

Blood Cancer J.

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There are significant disparities with regards to incidence, timely diagnosis, access to treatment, clinical trial participation and health care utilization that negatively impact outcomes for African American patients with multiple myeloma. Health care providers have a role in ameliorating these disparities with thoughtful consideration of historical, sociocultural, individual and disease characteristics that influence the care provided to African American patient population. This review by a group of experts committed to health disparity in multiple myeloma provides a snapshot of disparities at both biologic and non-biologic levels, barriers to clinical care, and best practices to ensure that African American patients receive the best care available.

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“…Multiple myeloma (MM), the second most common blood cancer, is a plasma cell malignancy frequently accompanied by hypercalcemia, immune dysfunction, and renal failure [ [1] , [2] , [3] ]. Despite the employment of various therapeutic methods, such as immunomodulatory agents, proteasome inhibitors, and autologous stem cell transplantation (ASCT), MM remains an incurable disease with nearly 160,000 new cases and 106,000 deaths annually [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, and activity evaluation of 2-iminobenzimidazoles as c-Myc inhibitors for treating multiple myeloma

Li,

Wang,

Yin

et al. 2024

Heliyon

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Multiple Myeloma for the Primary Care Provider: A Practical Review to Promote Earlier Diagnosis Among Diverse Populations

Cited by 22 publications

References 52 publications

Lesions of the spinal cord caused by multiple myeloma: A systematic review and meta-analysis regarding the neurosurgical aspects of patient management

Lesions of the spinal cord caused by multiple myeloma: A systematic review and meta-analysis regarding the neurosurgical aspects of patient management

Addressing the disparities: the approach to the African American patient with multiple myeloma

Design, synthesis, and activity evaluation of 2-iminobenzimidazoles as c-Myc inhibitors for treating multiple myeloma

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