Multiple myeloma in alcoholic liver cirrhosis.

Ito, Masahiro; Hsu, Chao‐Tien; Shikuwa, Saburo; Kawase, Yoshihisa; Sekine, Ichiro; Fujii, Hidemichi

doi:10.1620/tjem.157.39

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…Only 7.1% ( n = 2/28) of patients had monoclonal gammopathy of IgG λ‐type and, interestingly, both of these had alcoholic liver cirrhosis (Table ). Few case reports discussed the relationship between alcoholic liver cirrhosis and monoclonal gammopathy, and concluded it to be coincidental . On the other hand, polyclonal gammopathy was frequently observed in liver disease, including alcohol‐induced liver injury .…”

Section: Discussionmentioning

confidence: 99%

“…Few case reports discussed the relationship between alcoholic liver cirrhosis and monoclonal gammopathy, and concluded it to be coincidental. 12,13 On the other hand, polyclonal gammopathy was frequently observed in liver disease, including alcohol-induced liver injury. 10,14 Transformation from polyclonal to monoclonal gammopathy has been reported, which may be due to the establishment of a number of clones of B cells resulting from chronic antigen stimulation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Scleromyxedema and lichen myxedematosus: Is it associated with viral hepatitis?

Chen

Tzeng

Lee

et al. 2019

The Journal of Dermatology

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Scleromyxedema (SM) was previously known to be associated with monoclonal gammopathy. The association of SM and its counterpart lichen myxedematosus (LM) with chronic hepatitis has rarely been reported. We retrospectively reviewed medical records and histopathological reports of consecutive patients who presented at our department with the diagnosis of SM or LM from January 2001 to September 2017. The patients’ demographic details, cutaneous presentation, associated underlying diseases and hepatitic profile were studied and compared with previous published cases. In all, 28 patients were enrolled, including one SM, 19 LM and eight atypical LM. Of the patients, 50% (n = 14/28) had hepatitis. Of these, 21.4% (n = 6/28) had hepatitis C, 10.7% (n = 3/28) hepatitis B, 7.1% (n = 2/28) concurrent hepatitis B and C, whereas 10.7% (n = 3/28) had alcoholic liver disease. The prevalence of hepatitis C in our patients was 6.5‐times higher than that of the general population (28.6% vs 4.4%) and the prevalence of hepatitis B was similar (17.9% vs 17.3%). Polyclonal gammopathy was found in 28.6% (n = 8/28) of the patients and monoclonal gammopathy was found in 7.1% (n = 2/28). The extent of clonality did not correlate with disease severity. Our study did not notice a significant association with monoclonal gammopathy but the prevalence of hepatitis C was found to increase 6.5‐times in these patients compared with the general population. We recommend dermatologists to be aware of hepatitis investigations in such patients and future studies are warranted to understand the mechanism behind such association.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Scleromyxedema and lichen myxedematosus: Is it associated with viral hepatitis?

Chen

Tzeng

Lee

et al. 2019

The Journal of Dermatology

View full text Add to dashboard Cite

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“…11 In addition to an association between HCV infection and MM, a possible association between MM and alcoholic LC has also been reported. 12,13 While monoclonal gammopathy characterizes a group of B-cell disorders which result in the production of a specific and unique M-component, biclonal gammopathy is characterized by the simultaneous appearance of two different M-components. 14,15 Although biclonal gammopathy is relatively rare in M-proteinemia, the clinical features seem to be similar to those of monoclonal gammopathy.…”

Section: Biclonal Multiple Myeloma In Liver Cirrhosis Due To Hepatitimentioning

confidence: 99%

Biclonal multiple myeloma in liver cirrhosis due to hepatitis C virus infection

Tashiro

Tabaru

Narita

et al. 2003

Journal of Gastroenterology

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Henoch-Schönlein IgA glomerulonephritis complicating myeloma kidneys: case report

Arrizabalaga¹,

Saurina²,

Solé³

et al. 2003

Ann Hematol

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Myeloma kidney is the principal pathological substrate of rapidly progressive renal failure in multiple myeloma. We report the unusual case of a 72-year-old male diagnosed with kappa Bence Jones myeloma with renal failure which needed dialysis. After treatment with vincristine, doxorubicin (Adriamycin), dexamethasone (VAD), and plasmapheresis, the renal function was recovered until serum creatinine level was <2 mg/dl. Six months later, the pathological counterpart of rapidly progressive renal failure was crescentic IgA proliferative glomerulonephritis as a manifestation of Henoch-Schönlein syndrome associated with sepsis caused by coagulase-negative staphylococci. This case suggests that mesangial IgA deposition should be considered within the spectrum of consequent glomerular lesion-associated chemotherapy occurring in multiple myeloma.

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Multiple myeloma in alcoholic liver cirrhosis.

Cited by 4 publications

References 8 publications

Scleromyxedema and lichen myxedematosus: Is it associated with viral hepatitis?

Scleromyxedema and lichen myxedematosus: Is it associated with viral hepatitis?

Biclonal multiple myeloma in liver cirrhosis due to hepatitis C virus infection

Henoch-Schönlein IgA glomerulonephritis complicating myeloma kidneys: case report

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